Cyclotron 82Sr production for medical applications

Vereshchagin, Yu.I.; Zagryadskiy, V. A.; Prusakov, V.N.

doi:10.1016/0168-9002(93)90560-5

Cited by 14 publications

(4 citation statements)

References 3 publications

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“…Many solid target systems for cyclotrons have been described earlier in the literature and examples of such systems can be found within the Journal of Applied Radiation and Isotopes (Lebeda et al, 2005;Thisgaard et al, 2011), Nuclear Instruments and Methods in Physics Research (Čomor et al, 2004;Steyn et al, 2013;Vereshchagin et al, 1993) and the International Workshop on Targetry and Target Chemistry proceedings (Avila-Rodriques et al, 2006;Gelbart et al, 2012). Solid target systems can be categorized by beam power deposited in their targets; small scale ≈ 0.1 kW, medium scale ≈ 1 kW and large scale >1 kW targets.…”

Section: Introductionmentioning

confidence: 99%

A solid target system with remote handling of irradiated targets for PET cyclotrons

Siikanen¹,

Tran²,

Olsson³

et al. 2014

Applied Radiation and Isotopes

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Section: Introductionmentioning

confidence: 99%

A solid target system with remote handling of irradiated targets for PET cyclotrons

Siikanen¹,

Tran²,

Olsson³

et al. 2014

Applied Radiation and Isotopes

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“…In the process from past to present, many studies have been carried out on the production of 82 Sr by different nuclear reaction channels. For example, one of the proton bombardment studies, such as the 85 Rb(p,4n) 82 Sr reaction [7,8], has been done by Kastleiner et al in 2001. In the experimental study using the stacked foil technique, the margin of error has been calculated as 13-26% and best reaction cross section value obtained has been determined as 195 mb at 45 MeV [9]. Another study has been conducted by Buthelezi et al in 2006 [10] for the nat Rb(p,xn) 82 Sr [10,11] reaction.…”

Section: Introductionmentioning

confidence: 99%

Production cross-section and reaction yield of 82Sr for 82Sr/82Rb generator

Şentürk

Bayram

Akkoyun

2022

Cumhuriyet Science Journal

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There are many radioisotopes used for diagnostic and therapeutic purposes in nuclear medicine. One of the radioisotopes used for diagnostic purposes is 82Rb. It is used in positron emission tomography (PET) as to be positron emitter and commonly obtained from 82Sr/82Rb generator. In this study, we have investigated some possible production mechanisms of 82Sr by regarding 82Sr/82Rb generator. 85,87Rb(p,xn)82Sr and 80,82,83,84,86Kr(3He,xn)82Sr reaction channels have been investigated using the CTFGM, BSFGM, and GSM models within the framework of TALYS nuclear reaction code. It has been seen that the production cross-sections, reaction yields and total activation values calculated up to 60 MeV beam energy value are in agreement with the available data in the literature.

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“…Aside from the indicated reactions, 82 Sr can be obtained by irradiating gaseous krypton targets with 3 He or 4 He in cyclotrons, which are relatively inexpensive to operate, with average energy (E α, 3 He ≤ 60-70 MeV) [5,6]. The highest yield of 82 Sr in this method can be attained with a cascade target, consisting of modules highly enriched with krypton isotopes.…”

mentioning

confidence: 98%

“…These generators are compact, can be easily delivered to a clinic, including over large distances, and have a long service life. In addition, there is no need to have and operate a cyclotron in a clinic.At the present time, 82 Sr is obtained in the reactions Mo(p, spallation) and Rb(p, xn) in unique expensive high-energy (E p~ 100-800 MeV) accelerators which are intended for fundamental research [1][2][3][4]. Aside from the indicated reactions, 82 Sr can be obtained by irradiating gaseous krypton targets with 3 He or 4 He in cyclotrons, which are relatively inexpensive to operate, with average energy (E α, 3 He ≤ 60-70 MeV) [5,6].…”

mentioning

confidence: 99%

Experimental determination of 80,82,83Kr(α, xn)82Sr cross sections for reaction threshold to 60 MeV α-particles

et al. 2011

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The activation method has been used to determine the experimental cross sections of the nuclear reactions 80 Kr(α, 2n) 82 Sr, 82 Kr(α, 4n) 82 Sr, and 83 Kr(α, 5n) 82 Sr for α-particle energies from the reaction threshold to E α = 60 MeV on targets which are highly enriched with krypton isotopes. The structural and geometric parameters are established for a "thick" cascade target with krypton isotopes, which gives maximum 82 Sr yield for E α ≤ 60 MeV. The 82 Sr yield in the indicated target for initial energy E α = 60 MeV is estimated to be 3.4·10 6 Bq/(µA·h), which gives a basis for commercial applications of this isotope in medium-energy accelerators.One of the most promising and dynamically developing directions in nuclear medicine today is cardio-diagnostics based on positron emission tomography. Most positron emission tomography centers use ultra-short-lived β + remitting radionuclides ( 11 C, 13 N, 15 O, 18 F) and operate with two mandatory components: positron emission tomography and a cyclotron with E p < 20 MeV for producing the indicated isotopes. Undoubtedly, the need for a cyclotron is preventing wider use of PET, since not every clinic has a cyclotron. There is a more efficient approach to the solution of this problem.A method of positron emission tomography, based on the use of the isotope generators 82 Sr-82 Rb, has been developed, mainly, in the USA. These generators are compact, can be easily delivered to a clinic, including over large distances, and have a long service life. In addition, there is no need to have and operate a cyclotron in a clinic.At the present time, 82 Sr is obtained in the reactions Mo(p, spallation) and Rb(p, xn) in unique expensive high-energy (E p~ 100-800 MeV) accelerators which are intended for fundamental research [1][2][3][4]. Aside from the indicated reactions, 82 Sr can be obtained by irradiating gaseous krypton targets with 3 He or 4 He in cyclotrons, which are relatively inexpensive to operate, with average energy (E α, 3 He ≤ 60-70 MeV) [5,6]. The highest yield of 82 Sr in this method can be attained with a cascade target, consisting of modules highly enriched with krypton isotopes. In such a target, 82 Sr will be produced simultaneously on several krypton isotopes: on each krypton isotope in the α-particle energy range where the 82 Sr production cross section is larger than for other isotopes [7]. To realize such a cascade target, it is necessary to know the energy dependences of the cross sections of reactions in which 82 Sr is formed on all krypton isotopes. At the present time, there are no experimental data on the cross sections of the nuclear reactions 80,82,83 Kr(α, xn) 82 Sr. This makes it important to obtain the experimental cross sections of the nuclear reactions leading to the formation of 82 Sr on krypton isotopes.In the present work, the activation method was used to determine the experimental cross sections of the nuclear reactions 80 Kr(α, 2n) 82 Sr, 82 Kr(α, 4n) 82 Sr, and 83 Kr(α, 5n) 82 Sr at energies from the reaction threshold to ...

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Cyclotron 82Sr production for medical applications

Cited by 14 publications

References 3 publications

A solid target system with remote handling of irradiated targets for PET cyclotrons

A solid target system with remote handling of irradiated targets for PET cyclotrons

Production cross-section and reaction yield of 82Sr for 82Sr/82Rb generator

Experimental determination of 80,82,83Kr(α, xn)82Sr cross sections for reaction threshold to 60 MeV α-particles

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