CYP19A1 genetic polymorphisms may be associated with obesity-related phenotypes in Chinese women

Long, Jirong; Shu, Xiao‐Ou; Cai, Qiuyin; Wen, Wanqing; Kataoka, Nobuhiko; Gao, Yu‐Tang; Wang, Zheng

doi:10.1038/sj.ijo.0803439

Cited by 19 publications

(14 citation statements)

References 26 publications

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“…In a study of postmenopausal Caucasian women not using postmenopausal hormones, Paynter et al (24) reported that the rs28566535 C allele (5.1% of that study population) was not associated with risk of endometrial cancer nor with plasma steroid hormone levels. The minor C allele of rs28566535 has a much higher frequency (34.3%) in our study, which agrees with the frequency of this allele reported in a populationbased case-control study of breast cancer we conducted in Shanghai (38).…”

Section: Discussionsupporting

confidence: 81%

Polymorphisms in the CYP19A1 (Aromatase) Gene and Endometrial Cancer Risk in Chinese Women

Tao

Cai

Zhang

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Aromatase, encoded by the CYP19A1 gene, is a key enzyme in estradiol biosynthesis, which catalyzes the conversion of androstenedione and testosterone to estrone and estradiol, respectively. Given the critical role of estrogen in the development of endometrial cancer risk, we evaluated genetic polymorphisms of the CYP19A1 gene, including rs1065779, rs700519, rs28566535, rs752760, and rs1870050, in association with endometrial cancer in a population-based case-control study conducted in Shanghai, China. Genotypes of 1,040 incident endometrial cancer cases and 1,031 frequencymatched controls were included in the study. We applied a logistic regression model to derive adjusted odds ratios (OR) and their 95% confidence intervals (95% CI). Six common haplotypes with a frequency z5% were estimated; the highest frequency haplotype was GCACA (27.8% in cases and 26.2% in controls). We observed an inverse association between CYP19A1 haplotype TCATC and endometrial cancer in our population (OR, 0.76; 95% CI,). An inverse association was found between endometrial cancer and single nucleotide polymorphism rs1870050 in the promoter region with ORs of 0.81 (95% CI, 0.68-0.97) and 0.58 (95% CI, 0.42-0.80) for the AC and CC genotypes, respectively. We observed a multiplicative interaction between single nucleotide polymorphism rs700519 and body mass index among postmenopausal women (P = 0.01), with stronger associations between rs700519 genotypes and endometrial cancer risk among heavier (body mass index, z25) postmenopausal women. In summary, our data show that polymorphisms in the CYP19A1 gene may contribute to endometrial carcinogenesis. (Cancer Epidemiol Biomarkers Prev 2007;16(5):943 -9)

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Section: Discussionsupporting

confidence: 81%

Polymorphisms in the CYP19A1 (Aromatase) Gene and Endometrial Cancer Risk in Chinese Women

Tao

Cai

Zhang

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Young Korean women havea more westernized body shape than young Korean Chinese women. BMI and WHR or waist circumference can be used as indexes for overall obesity and central abdominal obesity to predict high risk behavior [6,23]. The average WHR of both groups was similar to that reported by Choung and Park [24]; however, it was lower than that reported in the 2001 Korea National Health and Nutrition Examination Survey [17].…”

Section: Discussionmentioning

confidence: 44%

Health Habit, Perceived Health Status and Physical Health Status of Young Korean and Korean-Chinese Women: A Comparative Study

Lee

2015

J Korean Acad Community Health Nurs

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Purpose: The purpose of this study was to compare health habit, physical health status, and perceived health status between young Korean and Korean-Chinese women. Methods: This study was conducted as a cross-sectional comparative survey. For this study, 114 Korean women were recruited in Seoul, South Korea and 64 Korean-Chinese women in Jilin Province, China through convenience sampling. Results: A positive correlation was found between health habit and perceived health status. Perceived health status, WHR, body density, flexibility, and muscle endurance were significantly lower in Korean women than in Korean-Chinese ones. Knee flexion and ankle dorsal flexion was significantly higher in Korean women than in Korean-Chinese ones. Conclusion:Further investigation is required to compare the two different groups that share the same ethnicity and similar culture but were born into different countries. A study such as this may provide answers regarding the influence of migrated transition on health.

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“…Most of those related to endometrial cancer are in an area of linkage disequilibrium (designated as Block 4 [35]) which includes the Ins/Del and the [TTTA] n repeat reported here. A study in China [36] found associations between BMI and variants in genotypes in Block 4 in healthy women, although different polymorphisms were studied and the association was found only in premenopausal women in that study.…”

Section: Discussionmentioning

confidence: 76%

Variants in hormone biosynthesis genes and risk of endometrial cancer

Olson

Orlow

Bayuga

et al. 2008

Cancer Causes Control

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We investigated the risk associated with variants in three genes involved in estrogen biosynthesis, CYP11A1, CYP17A1, and CYP19A1, in the population-based case control study of Estrogen, Diet, Genetics, and Endometrial Cancer. This study was conducted in New Jersey in 2001-2006 with 417 cases and 402 controls. For CYP11A1, there was no association between the number of [TTTTA] n repeats (D15S520) and risk. For CYP17A1, risk was somewhat lower among women with the C/C genotype at T-34C (rs743572) (adjusted OR=0.65, 95% CI 0.41-1.02). For CYP19A1, risk was lower among women homozygous for the 3-base pair deletion (rs11575899) in exon 4 (adjusted OR=0.44, 95% CI 0.26-0.76), while the number of [TTTA] n repeats was not significantly related to risk: the adjusted OR for n=7/7 repeats vs n>7/>7 repeats was 0.81 (95% CI 0.54-1.23). In stratified analyses, results for CYP19A1 were stronger among women with higher (>27.4) body mass index: for the homozygous deletion, OR=0.30 (95% CI 0.15-0.62); for the n=7/7 genotype, OR=0.49 (95% CI 0.26-0.93). The interaction between the n=7/7 genotype and BMI was statistically significant (p=0.01). The insertion/deletion variant in CYP19A1 appears to be related to risk of endometrial cancer; risk associated with variants in this gene may vary according to BMI.

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CYP19A1 genetic polymorphisms may be associated with obesity-related phenotypes in Chinese women

Cited by 19 publications

References 26 publications

Polymorphisms in the CYP19A1 (Aromatase) Gene and Endometrial Cancer Risk in Chinese Women

Polymorphisms in the CYP19A1 (Aromatase) Gene and Endometrial Cancer Risk in Chinese Women

Health Habit, Perceived Health Status and Physical Health Status of Young Korean and Korean-Chinese Women: A Comparative Study

Variants in hormone biosynthesis genes and risk of endometrial cancer

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