Variants in hormone biosynthesis genes and risk of endometrial cancer

Olson, Sara H.; Orlow, Irene; Bayuga, Sharon; Sima, Camelia S.; Bandera, Elisa V.; Pulick, Katherine; Faulkner, Shameka; Tommasi, Diana V.; Egan, Daniel; Roy, Pampa; Wilcox, Homer; Ali, Asya; Modica, Ippolito; Asad, Haider; Soslow, Robert A.; Zauber, Ann G.

doi:10.1007/s10552-008-9160-7

Cited by 32 publications

(23 citation statements)

References 38 publications

(39 reference statements)

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“…11,27 Several studies showed that the SNP rs743572 in CYP17A1 appears to be associated with a reduced risk of endometrial cancer, 27,28 but there is some evidence that this SNP increases risk of non-Hodgkin lymphoma. 29 In the present study, we investigated the effects of rs11191548 in Chinese children.…”

Section: Resultsmentioning

confidence: 99%

A sex-specific effect of the CYP17A1 SNP rs11191548 on blood pressure in Chinese children

Zhang

et al. 2011

J Hum Hypertens

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CYP17A1 gene encodes the cytochrome P450 enzyme CYP17A1, a key enzyme involved in steroid metabolism. A single nucleotide polymorphism (SNP) near CYP17A1, rs11191548, showed significant association with hypertension in European adults. However, this association has not been demonstrated in children thus far. Additionally, the role of CYP17A1 in elevating blood pressure (BP) is unclear. We investigated the association of rs11191548 with hypertension in Chinese children. A total of 3422 children participated in the study, including 1009 children with elevated BP (EBP, including prehypertension and hypertension) and 2413 children with normal BP. SNP rs11191548 was associated with systolic BP (SBP) (CC vs TT: P ¼ 4.8 Â 10 28--0.77, P ¼ 0.003) in girls, but there was no statistically significant association between the SNP and diastolic BP in boys or girls. Our results also showed that rs11191548 was more significantly associated with SBP and EBP in obese girls than in girls of normal weight. Our study indicated that the SNP rs11191548, near CYP17A1, was associated with EBP in children. Moreover, we found a sex-specific effect of rs11191548 on SBP in Chinese children. Further studies are necessary to clarify the association between this CYP17A1 polymorphism and BP.

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Section: Resultsmentioning

confidence: 99%

A sex-specific effect of the CYP17A1 SNP rs11191548 on blood pressure in Chinese children

Zhang

et al. 2011

J Hum Hypertens

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“…Methods in this study have been described in detail elsewhere [18-20]. In brief, the source population for the EDGE study comprised women older than 21 years living in one of these six NJ counties (Bergen, Essex, Hudson, Middlesex, Morris, and Union) and able to understand English or Spanish.…”

Section: Methodsmentioning

confidence: 99%

Adherence to the dietary guidelines for Americans and endometrial cancer risk

Chandran

Bandera

Williams-King

et al. 2010

Cancer Causes Control

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The Healthy Eating Index (HEI) was developed by the US Department of Agriculture with the goal of quantifying adherence to the Dietary Guidelines for Americans. The purpose of this study was to evaluate the impact of the HEI-2005 score and each of its components on endometrial cancer risk in a population-based case-control study in New Jersey. A total of 424 cases and 398 controls completed a Food Frequency Questionnaire, which was used to derive the HEI-2005 score. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression while adjusting for potential covariates, which included all major endometrial cancer risk factors. The adjusted OR for women in the highest quartile when compared to the lowest quartile was 0.83 (95% CI: 0.52-1.34). For the meat and beans component comprising meat, eggs, poultry, fish, and beans, the OR was 0.70 (95% CI: 0.45-1.11; p for trend: 0.07), with little evidence of an association with any of the individual foods. There was no indication of an association for any of the other components of the HEI or of effect modification by body mass index. This study suggested limited value for the HEI-2005 in predicting endometrial cancer risk.

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“…The methods used in the EDGE Study (Estrogen, Diet, Genetics, and Endometrial Cancer) have been described elsewhere [13]. In brief, women older than 21 years and able to understand English or Spanish, and living in one of six NJ counties (Bergen, Essex, Hudson, Middlesex, Morris, and Union) were eligible to participate in the study.…”

Section: Methodsmentioning

confidence: 99%

Phytoestrogen consumption and endometrial cancer risk: a population-based case–control study in New Jersey

Bandera

Williams

Sima

et al. 2009

Cancer Causes Control

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Phytoestrogens have been shown to exert anti-estrogenic and estrogenic effects in some tissues, including the breast. However, only a few studies have evaluated their role in endometrial cancer risk. We evaluated this association in a population-based case-control study in New Jersey. A total of 424 cases and 398 controls completed an interview, including a food frequency questionnaire with supplemental questions for phytoestrogen foods. Risk estimates were derived using unconditional logistic regression, adjusting for major risk factors for endometrial cancer. There was some suggestion of a decreased risk with quercetin intake (OR: 0.65; 95% CI: 0.41-1.01 for the highest compared to the lowest quartile; p for trend: 0.02). We found limited evidence of an association with any of the lignans evaluated, total lignans, coumestrol, individual isoflavones, total isoflavones, or total phytoestrogens. However, there was some suggestion of an inverse association with total isoflavone intake limited to lean women (BMI <25) (OR for the highest tertile: 0.50, 95% CI: 0.25-0.98) and those with a waist-to-hip ratio ≤0.85 (OR: 0.59; 95% CI: 0.33-1.05). There was no evidence of effect modification by HRT use. This study suggests a reduction in endometrial cancer risk with quercetin intake and with isoflavone intake in lean women.

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Variants in hormone biosynthesis genes and risk of endometrial cancer

Cited by 32 publications

References 38 publications

A sex-specific effect of the CYP17A1 SNP rs11191548 on blood pressure in Chinese children

A sex-specific effect of the CYP17A1 SNP rs11191548 on blood pressure in Chinese children

Adherence to the dietary guidelines for Americans and endometrial cancer risk

Phytoestrogen consumption and endometrial cancer risk: a population-based case–control study in New Jersey

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