CYP2E1 and L-myc EcoRI Gene Polymorphisms and Heavy Metals Exposure in Hepatocellular Carcinoma Patients

Abo-Has, Ekbal M.; El-Wakil, Mohamed; Shabana, Yasser M.; El-Metwall, M.A.; El-Kannish, Ghada; Anwar, Rokiah; Fawzy, Eman; Elzayat, Mostafa; Saied, Narmin

doi:10.3923/ijcr.2020.48.53

Cited by 1 publication

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“…Already done researches have reported the association among genetic vulnerability of gene and hepatic disease, i.e., aldehyde dehydrogenase 2 (ALDH2) and hepatocellular carcinoma [7], interleukin-2, IFN-γ, interleukin-10, and hepatitis B and C virus or their coinfection [8] and CYP2E1 gene as well as hepatocellular carcinoma [9]. But this type of association is not fully explored yet.…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Correlation Analysis of Cytochrome P450 SNPs in Hepatitis B‐Caused Cirrhosis Patients

Li,

Yang,

Guo

2022

BioMed Research International

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Aim. The aim of the present research was to find the correlation of single nucleotide polymorphisms (SNPs) of cytochrome P450 (CYP450) and hepatitis B-caused cirrhosis. Methods. Collection of specimens was done from 297 volunteers with confirmed hepatitis B-caused cirrhosis as well as 120 healthy volunteers in China. Individuals were categorized into three classes, i.e., A, B, and C, on the basis of the Child-Pugh-Turcotte (CPT) value of diseased people, while the Child-Pugh-Turcotte score was determined by rating the below mentioned 5 parameters, i.e., serum volume of bilirubin as well as albumin, prothrombin time, ascites, and encephalopathy. Twenty-four SNPs in the CYP450 superfamily including CYP1A2, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CY3A4 were detected using the SNaPshot assay. Results. CYP1A2-G2964A, CYP1A2-C733A, and CYP1A2-T5347C in all 24 SNP loci attained significance. AA genotype at CYP1A2-G2964A (P=0.048) and CC genotype at CYP1A2-T5347C (P=0.049) were significantly correlated with hepatitis B-caused cirrhosis. Moreover, an allele at CYP1A2-G2964A (P=0.032) and C allele at CYP1A2-T5347C (P=0.016) were associated with hepatitis B-caused cirrhosis. Furthermore, AC plus AA genotype at CYP1A2-C733A correlated with a TCM syndrome, “damp abundance due to spleen asthenia syndrome” (P=0.039) in individuals suffering from hepatitis B-resulted cirrhosis. Conclusion. The findings of the current study suggested that AA genotype at CYP1A2-G2964A and CC genotype at CYP1A2-T5347C may be higher risk in the occurrence of hepatitis B-caused cirrhosis. Moreover, patients with AC plus AA genotype at CYP1A2-C733A may be susceptible to appear having “damp abundance due to spleen asthenia syndrome.”

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Section: Introductionmentioning

confidence: 99%