Cypate‐mediated thermosensitive nanoliposome for tumor imaging and photothermal triggered drug release

Han, Zhihao; Lv, Liwei; Ma, Yi; Wang, Zhaohui; Liu, Yuxi; Zhang, Min; Li, Siwen; Gu, Yueqing

doi:10.1002/jbio.201600270

Cited by 11 publications

(8 citation statements)

References 22 publications

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“…Zhihao Han et al. from China Pharmaceutical University synthesized a Cypate‐mediated thermosensitive nanoliposome for tumor imaging and photothermal triggered drug release . Shu Wang et al.…”

Section: Research Interests Indicated By Jbpmentioning

confidence: 99%

Biophotonics in China

Shi

Luo

2017

Journal of Biophotonics

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Biophotonics is a highly interdisciplinary field where physicists, chemists, biologists, physicians and engineers work together to solve the problems appearing in biology and medicine. In China, the Biophotonics discipline is often referred to as Biomedical Photonics, under the first‐level disciplines Biomedical Engineering or Optical Engineering, and was initiated in the late 1990s. Over the past 20 years, biophotonics research in China expanded extraordinarily and has reached the frontiers of the world‐level sciences. This white paper introduces the research groups in the biophotonics field in China, and their representative contributions.

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Section: Research Interests Indicated By Jbpmentioning

confidence: 99%

Biophotonics in China

Shi

Luo

2017

Journal of Biophotonics

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“…While Prussian blue staining showed an efficient uptake of PSC NPs by cells, we were still concerned about the undesirable effect of NPs, such as cytotoxicity. As PLGA and cypate have been shown to have excellent biocompatibility, 54 , 55 SPIO is the only suspect of the undesirable effect. For instance, excessive SPIO particles may lead to an imbalance of intracellular iron concentration and osmotic pressure homeostasis, which leads to cellular damage.…”

Section: Resultsmentioning

confidence: 99%

Magnetic Nano-Platform Enhanced iPSC-Derived Trabecular Meshwork Delivery and Tracking Efficiency

Wang

Cao

et al. 2022

IJN

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Purpose Transplantation of stem cells to remodel the trabecular meshwork (TM) has become a new option for restoring aqueous humor dynamics and intraocular pressure homeostasis in glaucoma. In this study, we aimed to design a nanoparticle to label induced pluripotent stem cell (iPSC)-derived TM and improve the delivery accuracy and in vivo tracking efficiency. Methods PLGA-SPIO-Cypate (PSC) NPs were designed with polylactic acid-glycolic acid (PLGA) polymers as the backbone, superparamagnetic iron oxide (SPIO) nanoparticles, and near-infrared (NIR) dye cypate. In vitro assessment of cytotoxicity, iron content after NPs labeling, and the dual-model monitor was performed on mouse iPSC-derived TM (miPSC-TM) cells, as well as immortalized and primary human TM cells. Cell function after labeling, the delivery accuracy, in vivo tracking efficiency, and its effect on lowering IOP were evaluated following miPSC-TM transplantation in mice. Results Initial in vitro experiments showed that a single-time nanoparticles incubation was sufficient to label iPSC-derived TM and was not related to any change in both cell viability and fate. Subsequent in vivo evaluation revealed that the use of this nanoparticle not only improves the delivery accuracy of the transplanted cells in live animals but also benefits the dual-model tracking in the long term. More importantly, the use of the magnet triggers a temporary enhancement in the effectiveness of cell-based therapy in alleviating the pathologies associated with glaucoma. Conclusion This study provided a promising approach for enhancing both the delivery and in vivo tracking efficiency of the transplanted cells, which facilitates the clinical translation of stem cell-based therapy for glaucoma.

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“…TSL was stable up to 39 °C, with drug leakage of PTX, R837 or IR820 less than 6%. The TSL started to be disassembled into pieces at 40 °C with an abrupt release at 41 °C and reached to the maximum level at 43 °C, since the melting point of TSL was about 43 °C . The release profiles of TSL's contents in PTX‐R837‐IR820@TSL were also monitored in 30 mL PBS (0.2 m , pH = 7.4) containing 0.5% (w/w) of Tween‐80 at 43 °C and 37 °C (Figure B,C).…”

Section: Resultsmentioning

confidence: 99%

Photothermal/Photodynamic Therapy with Immune‐Adjuvant Liposomal Complexes for Effective Gastric Cancer Therapy

Meng

Wang

Lv³

et al. 2019

Part & Part Syst Charact

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A diagnosis and therapeutic strategy for gastric cancer is developed herein by combining thermosensitive liposomal (TSL)‐based photothermal/photodynamics therapy (PTT/PDT) with chemotherapy and adjuvant immunotherapy. IR820, a photothermal agent, paclitaxel (PTX), an antitumor drug, and imiquimod (R837), a Toll‐like‐receptor‐7 agonist, are coencapsulated into a TSL drug delivery system. These formed PTX‐R837‐IR820@TSL complexes exhibit excellent optical properties, good dispersibility, and stability. Under NIR light irradiation, the measurement of singlet oxygen production and thermal efficiency indicate promising potential of PTX‐R837‐IR820@TSL complexes for PTT and PDT. Confocal microscopy and small animal NIR imaging demonstrate tumor targeting ability of the liposomal complexes to gastric cancer cells. In vitro cell viability assays and in vivo animal experiments show prominent antitumor efficiency of PTX‐R837‐IR820@TSL complexes upon NIR light irradiation. This excellent therapeutic efficacy is attributed to the simultaneous chemotherapy and PTT/PDT. Furthermore, the liposomal complexes under NIR irradiation would ablate tumors to generate a pool of tumor‐associated antigens, which is able to promote strong antitumor immune responses in the presence of those R837‐containing liposomal complexes acted as adjuvant. These results indicate that the multifunctional liposomal complexes could realize a remarkable synergistic therapeutic outcome in gastric carcinoma.

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Cypate‐mediated thermosensitive nanoliposome for tumor imaging and photothermal triggered drug release

Cited by 11 publications

References 22 publications

Biophotonics in China

Biophotonics in China

Magnetic Nano-Platform Enhanced iPSC-Derived Trabecular Meshwork Delivery and Tracking Efficiency

Photothermal/Photodynamic Therapy with Immune‐Adjuvant Liposomal Complexes for Effective Gastric Cancer Therapy

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