Cyperus esculentus suppresses hepato-renal oxidative stress, inflammation, and caspase-3 activation following chronic exposure to sodium fluoride in rats’ model

Adelakun, Sunday Aderemi; Ogunlade, Babatunde; Fidelis, Obinna P.; Adedotun, Oluwafemi Abidemi

doi:10.1016/j.phyplu.2021.100163

Cited by 10 publications

(4 citation statements)

References 38 publications

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“…The highest limit of detection was 33.3 m. After 24 h, animals were sedated with pentobarbital sodium (40 mg/kg, i.p.) [ 48 ]. To separate serum, blood samples were taken from the jugular vein and centrifuged for 10 min at 3000 rpm.…”

Section: Methodsmentioning

confidence: 99%

Therapeutic effects of aqueous extract of bioactive active component of Ageratum conyzoides on the ovarian-uterine and hypophysis-gonadal axis in rat with polycystic ovary syndrome: Histomorphometric evaluation and biochemical assessment

et al. 2022

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Section: Methodsmentioning

confidence: 99%

Therapeutic effects of aqueous extract of bioactive active component of Ageratum conyzoides on the ovarian-uterine and hypophysis-gonadal axis in rat with polycystic ovary syndrome: Histomorphometric evaluation and biochemical assessment

et al. 2022

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“…According to earlier studies, fluorine can cause geno‐toxicity, cyto‐toxicity, immune‐toxicity, oxidative stress, and apoptosis in the liver and kidney at high doses [8–11] . However, to best of our knowledge no information is available regarding how HES works as a protective mechanism to fight against testes toxicity caused.…”

Section: Introductionmentioning

confidence: 99%

“…The formation of free oxygen radicals in cells is among the most severe side effects of NaF [8] . Excess fluoride intake has been reported to cause oxidative stress in mammalian tissues, [9] change gene expression and regulate many signalling pathways including the mitogen‐activated protein kinase (MAPK) [10] and nuclear factor kappa B (NF‐kB) pathways [11] that involved in proliferation and cell death. Although several mechanisms of fluoride toxicity have been proposed, oxidative stress has lately been recognised as a fundamental mechanism of fluoride‐induced organ specific diseases [8] .…”

Section: Introductionmentioning

confidence: 99%

“…[14] According to earlier studies, fluorine can cause geno-toxicity, cyto-toxicity, immune-toxicity, oxidative stress, and apoptosis in the liver and kidney at high doses. [8][9][10][11] However, to best of our knowledge no information is available regarding how HES works as a protective mechanism to fight against testes toxicity caused. Therefore, the current study was designed to examine the efficacy of HES on mitigating oxidative stress, apoptosis, autophagy and endoplasmic reticu-lum stress against NaF induced testicular damage in rats.…”

Section: Introductionmentioning

confidence: 99%

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Contribution of Oxidative Stress, Apoptosis, Endoplasmic Reticulum Stress and Autophagy Pathways to the Ameliorative Effects of Hesperidin in NaF‐Induced Testicular Toxicity

Kızıl¹,

Gür²,

Ayna³

et al. 2023

Chemistry & Biodiversity

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The ameliorative effects of hesperidin (HES) on the toxicities created by sodium fluoride (NaF) in the testes tissue of rats were studied via oxidative stress, apoptosis and endoplasmic reticulum (ER) stress pathways. The animals were divided into five distinct groups (7 rats in each group). Group 1 was control group, group 2 received NaF-only (600 ppm), group 3 received HES-only (200 mg/kg bw); group 4 received NaF (600 ppm) + HES (100 mg/kg bw) and group 5 received NaF (600 ppm) + HES (200 mg/kg bw) for 14 days. NaF-induced testes tissue damage by reducing activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and levels of glutathione (GSH), and increasing lipid peroxidation levels. NaF treatment significantly downregulated the mRNA levels of SOD1, CAT and GPx. NaF supplementation caused apoptosis in the testes by upregulating p53, NFkB, caspase-3, caspase-6, caspase-9, and Bax and downregulating Bcl-2. Furthermore, NaF caused ER stress via increasing mRNA transcript levels of PERK, IRE1, ATF-6 and GRP78. NaF treatment led to autophagy via upregulation of Beclin1, LC3A, LC3B and AKT2. In testes tissue, however, co-treatment with HES at doses of 100 and 200 mg/kg significantly reduced oxidative stress, apoptosis, autophagy and ER stress. Overall, the findings of this study suggest that HES may help to reduce testes damage caused by NaF toxicity.

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Fermented Rooibos tea (Aspalathus linearis) Ameliorates Sodium Fluoride-Induced Cardiorenal Toxicity, Oxidative Stress, and Inflammation via Modulation of NF-κB/IκB/IκKB Signaling Pathway in Wistar Rats

Ajuwon,

Adeleke,

Ajiboye

et al. 2024

Cardiovasc Toxicol

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Cyperus esculentus suppresses hepato-renal oxidative stress, inflammation, and caspase-3 activation following chronic exposure to sodium fluoride in rats’ model

Cited by 10 publications

References 38 publications

Therapeutic effects of aqueous extract of bioactive active component of Ageratum conyzoides on the ovarian-uterine and hypophysis-gonadal axis in rat with polycystic ovary syndrome: Histomorphometric evaluation and biochemical assessment

Therapeutic effects of aqueous extract of bioactive active component of Ageratum conyzoides on the ovarian-uterine and hypophysis-gonadal axis in rat with polycystic ovary syndrome: Histomorphometric evaluation and biochemical assessment

Contribution of Oxidative Stress, Apoptosis, Endoplasmic Reticulum Stress and Autophagy Pathways to the Ameliorative Effects of Hesperidin in NaF‐Induced Testicular Toxicity

Fermented Rooibos tea (Aspalathus linearis) Ameliorates Sodium Fluoride-Induced Cardiorenal Toxicity, Oxidative Stress, and Inflammation via Modulation of NF-κB/IκB/IκKB Signaling Pathway in Wistar Rats

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