Cystadenoma: a rare tumor originated in minor salivary gland

Santos, Jean Nunes dos; Barros, Ângela Ferreira; Sarmento, Viviane Almeida; Gurgel, Clarissa Araújo Silva; Souza, Verônica Ferreira de

doi:10.1590/s1676-24442008000300008

Cited by 9 publications

(13 citation statements)

References 12 publications

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“…Also, cystadenoma lacks evidence of infiltration in submucosa and muscle tissues. Moreover, the presence of features such as the pattern of solid growth in focal areas, cellular atypia, mode of invasion, permeation or destruction of glandular parenchyma and breakdown of the glandular lobe architecture helps in the diagnosis of PCC 8 19…”

Section: Discussionmentioning

confidence: 99%

Papillary cystadenocarcinoma of the hard palate

Wanjari¹,

Wanjari²,

Patidar³

et al. 2014

BMJ Case Reports

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SUMMARYPapillary cystadenocarcinoma (PCC) is an uncommon malignant tumour of the salivary gland, sometimes involving the minor salivary gland. Previously this entity was classified as an atypical type of adenocarcinoma, malignant papillary cystadenoma, low-grade papillary adenocarcinoma or mucus producing adenopapillary carcinoma. PCC is a glandular tumour with an indolent biological behaviour characterised by cysts and papillary endophytic projections. We report two cases of PCC involving the minor salivary gland of the hard palate. Both the patients presented with a swelling in the palate with difficulty in chewing. MRI revealed an extensively destructive lesion involving hard palate, alveolar ridge and maxillary antrum. Clinical and radiological features suggested the malignant nature of the lesion. Histopathology of incisional biopsy revealed tumour proliferation in a multicystic pattern, with extensive papillary proliferation. Diverse and cellular cytomorphology, and cellular and nuclear pleomorphism with few mitotic figures were the prominent features. Both the lesions were confirmed as PCC. BACKGROUND

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Section: Discussionmentioning

confidence: 99%

Papillary cystadenocarcinoma of the hard palate

Wanjari¹,

Wanjari²,

Patidar³

et al. 2014

BMJ Case Reports

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“…9 The usual presentation is an asymptomatic mass present for several years before diagnosis. 3 The biological behavior of this tumor is similar to that of Warthin's tumor. Recurrences are unusual and probably represent mutifocality.…”

Section: Dear Dr Bedrossianmentioning

confidence: 76%

“…They have been reported in accessory tear glands, minor salivary glands of buccal mucosa, soft palate and lip, nasopharynx, larynx, and infrequently in parotid glands. [1][2][3][4][5][6][7][8] The lesion tends to occur more frequently in women; most patients are older then 50 years of age. 9 The usual presentation is an asymptomatic mass present for several years before diagnosis.…”

Section: Dear Dr Bedrossianmentioning

confidence: 99%

Oncocytic papillary cystadenoma of parotid gland: A diagnostic challenge on fine‐needle aspiration cytology

Gupta

Sodhani

Jain

et al. 2010

Diagnostic Cytopathology

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Oncocytic papillary cystadenomas (OPC) of the head and neck are rare tumors. They have been reported in accessory tear glands, minor salivary glands of buccal mucosa, soft palate and lip, nasopharynx, larynx, and infrequently in parotid glands. [1][2][3][4][5][6][7][8] The lesion tends to occur more frequently in women; most patients are older then 50 years of age. 9 The usual presentation is an asymptomatic mass present for several years before diagnosis. 3 The biological behavior of this tumor is similar to that of Warthin's tumor. Recurrences are unusual and probably represent mutifocality. 10 The cytological features of this lesion have not been well documented in literature, and histopathology is mandatory to arrive at a final diagnosis. 1,7,[11][12][13][14][15][16] A 75-year-old male presented with a slightly painful swelling in right upper posterior cervical region, just below the angle of mandible, slowly increasing in size over a year. On examination, the swelling measured 2.5 cm in diameter, was firm, slightly tender, and mobile. The patient gave the history of root abscess in the 2nd right lower molar tooth and took antibiotics for it off and on. He was referred for fine-needle aspiration (FNA) with a clinical diagnosis of lymphadenitis. FNA was performed on two occasions at an interval of 1 week. Both times whitish turbid fluid was aspirated. The smears were air dried for Giemsa staining and wet fixed for Papanicolaou (Pap) staining. Smears from the first aspirate revealed a necrotic inflammatory background with presence of scattered atypical squamous cells including an occasional orangeophilic cell with pyknotic nucleus, tadpole and fibre cells on Pap stain (Fig. 1). The differential diagnoses considered were cystic squamous cell carcinoma, branchial cyst, infracted pleomorphic adenoma, and infracted Warthin's Tumor. As there was no obvious primary malignancy and the patient was clinically well preserved, a second FNA from a different site was advised after a course of antibiotics. This aspirate showed a different picture, comprising of many vacuolated cells, some containing pinkish mucinous material and some with a signet ring appearance (Fig. 2). In addition, there were a few atypical squamous cells and an occasional multinucleated giant cell with atypical hyperchromatic nuclei against a mucoid inflammatory background (Fig. 3). The differential diagnoses offered included mucoepidermoid tumor, Warthin's tumor, and cystic adenosquamous carcinoma. The CT scan of head and neck region performed at this time revealed a circumscribed swelling in the lower pole of parotid gland. The swelling was excised under local anaesthesia and on histopathology; a diagnosis of oncocytic papillary cystadenoma of parotid gland was returned (Fig. 4). There were no mucin-containing cells or features of squamous malignancy on histopathology sections. Because of these noncorrelating features on histology, the FNA smears were reviewed. No characteristic oncocytic cells or papillary structures were found in the smears even on ...

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“…Among the cases reviewed, majority of cystadenomas occurred in patients above the age of 50 years (Table 2). According to the literature, the cystadenomas are more frequent in males than in females [5], but occasionally female predominance is mentioned (male to female ratio 1:2.3) [11]. Among the 28 case reports summarized in Table 2, the incidence is higher in males (n = 15) compared with females (n = 12) with female to male ratio of 1:1.25.…”

Section: Discussionmentioning

confidence: 98%

“…Cystadenoma typically presents as a slow growing, painless mass, usually \1 cm in greatest dimension when arising in the minor salivary glands [10] with one case reporting 1.5 cm in its maximum diameter in buccal mucosa [11].…”

Section: Introductionmentioning

confidence: 99%

A Rare Case Report of Mucinous Cystadenoma with Immunohistochemical Analysis and Review of Literature

Girotra

Padhye

Mahajan

et al. 2014

J. Maxillofac. Oral Surg.

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Cystadenomas are rare salivary gland tumours characterised by prominent epithelium-lined papillary projections into the cystic spaces. A 37 year-old female, presented with a swelling on the right side of the hard palate. Clinically, the swelling was soft, fluctuant, sessile and non-tender measuring 2.5 9 2 cm in diameter. Excisional biopsy was performed. The histopathological and immunohistochemical features were characteristic of mucinous cystadenoma. There has been no recurrence over a 2-year follow up period. The article highlights its clinical, histopathological, immunohistochemical features and differential diagnosis along with review of literature. Cystadenoma of the palate is rare, papillary variety being more common than mucinous with very few cases reported in literature.

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Cystadenoma: a rare tumor originated in minor salivary gland

Abstract: Cystadenoma of salivary glands is an uncommon benign neoplasm that presents intraluminal

Cited by 9 publications

References 12 publications

Papillary cystadenocarcinoma of the hard palate

Papillary cystadenocarcinoma of the hard palate

Oncocytic papillary cystadenoma of parotid gland: A diagnostic challenge on fine‐needle aspiration cytology

A Rare Case Report of Mucinous Cystadenoma with Immunohistochemical Analysis and Review of Literature

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