Cystadenomas and Cystadenocarcinomas of the Pancreas

Borgne, J. Le; Calan, L. De; Partensky, C

doi:10.1097/00000658-199908000-00004

Cited by 420 publications

(98 citation statements)

References 37 publications

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“…However, the prevalence of malignancy among the rare serous cystic neoplasms of the pancreas has not yet been investigated. Some authors even neglect the existence of pancreatic serous cystic cancer, as they do not distinguish between adenoma and carcinoma in serous cystic lesions or classify them as benign tumors [7, 8, 9, 10]. Some authors therefore recommend that resection in serous cystic neoplasms can be reserved for symptomatic patients [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Risk of Malignancy in Serous Cystic Neoplasms of the Pancreas

et al. 2003

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Background: In contrast to mucinous cystic neoplasms of the pancreas, which are known to have considerable malignant potential, the serous variant is generally thought to be benign. There are, however, several reports of malignancy in serous cystic neoplasms of the pancreas. Aims: To assess the risk of malignancy of serous cystic tumors of the pancreas and to investigate specific clinical and histological features. Methods: Clinical and pathological characteristics of benign and malignant serous cystic neoplasms of the pancreas were investigated by a review of the literature and documented by a case of a serous cystadenocarcinoma and immunohistochemical analysis of a series of serous cystadenomas. Reviewing the literature prevalence, age and sex distribution of serous cystic neoplasms were analyzed. Results: The prevalence of cancer among serous cystic neoplasms reported since 1989 was 3%. Serous cystadenoma of the pancreas present at an earlier age (61 years) than serous cystadenocarcinoma (66 years; p = 0.056) and are symptomatic in the majority of patients.Pathological examination of the primary tumor was not able to distinguish cystadenoma from cystadenocarcinoma in 38% of cases. In 25% the diagnosis of cancer was established only after growth of metachronous metastases. In the present case, nuclear atypia, papillary structures, proliferation marker Ki-67 and p53 protein were increased in the primary tumor and/or metachronous metastasis. Conclusion: Serous cystic neoplasms of the pancreas do have malignant potential with a risk of malignancy of 3% and should be surgically treated if the operative risk is acceptable. Routine analysis of genetic and proliferation markers may improve diagnosis of malignancy in these tumors.

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Section: Introductionmentioning

confidence: 99%

Risk of Malignancy in Serous Cystic Neoplasms of the Pancreas

et al. 2003

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“…L'EA est une des méthodes de diagnostic fortuite des lésions kystiques pancréatiques en nette augmentation depuis quelques années [8,9].…”

Section: L'échographie Abdominale Peut-elle Identifier Les Petites Léunclassified

La prévention du cancer du pancréas (CP) - Rôle primordial de l’échographie abdominale (EA)

Dalbiès¹,

Létard²,

Patrick³

2017

Hegel

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Résumé Objectifs :ADéterminer si l'EA est un moyend 'imagerie morphologique pertinent pour le pancréas ; AL'apport de l'EA dans le diagnostic des lésions pancréatiques ; AL'intérêt dans le suivi des facteurs de risque de dégénérescence.La revue de la littérature et l'expérience des auteurs permettent de répondreo ui à l'ensemble de ces questions en ajoutant :quand l'échographie abdominale est réaliséedans de bonnes conditions avecu nm atériel idoine et un opérateur professionnel entraîné. Mots-clésEchographie abdominale ;T echnique d'examen ;L é sions de découvertes fortuites ;F acteurs de risque de dégénérescence ;L é sions solides et kystiques AbstractObjectives:

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“…If found they should be resected to avoid malignant transformation. Differentiation between pancreatic serous cystadenoma and mucinous cystadenoma is difficult and is based on fine needle aspiration (FNA) that will reveal in the later high levels of carcinoembryonic antigen (CEA) in the aspirated fluid as well as a low level of pancreatic enzymes [35,36]. They are cystic pancreatic masses, usually multilocular, rarely unilocular when they must be differentiated from pancreatic pseudocysts and from serous cystadenomas [37][38][39][40][41].…”

Section: Mucinous Cystadenomas and Cystadenocarcinomasmentioning

confidence: 99%

Contrast‐Enhanced Ultrasound for the Assessment of Pancreatic Lesions

Şirli¹,

Popescu²

2017

Challenges in Pancreatic Pathology

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Transabdominal ultrasound (US) is the first-line imaging method used to diagnose pancreatic lesions, but contrast techniques are needed to differentiate among inflammatory and malignant lesions, as well as between pseudocysts and cystic tumors. Contrast-enhanced (CE) ultrasonography has been proven to be a useful tool in this regard with performance similar to contrast-enhanced computer tomography/magnetic resonance imaging (CT/MRI), being also safer and nonirradiant. According to the EFSUMB guidelines on the nonhepatic use of contrast-enhanced ultrasound (CEUS), this method is useful to improve characterization of ductal adenocarcinoma; to differentiate between pseudocysts and cystic tumors; to differentiate vascular (solid) from avascular (liquid/necrotic) components of a lesion; to better define the dimensions and margins of a lesion, including its relationship with adjacent vessels; and to help the choice for a next imaging technique.

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Cystadenomas and Cystadenocarcinomas of the Pancreas

Cited by 420 publications

References 37 publications

Risk of Malignancy in Serous Cystic Neoplasms of the Pancreas

Risk of Malignancy in Serous Cystic Neoplasms of the Pancreas

La prévention du cancer du pancréas (CP) - Rôle primordial de l’échographie abdominale (EA)

Contrast‐Enhanced Ultrasound for the Assessment of Pancreatic Lesions

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