Cystatin C in the early diagnosis of diabetic nephropathy and its correlation with albuminuria

Gupta, Kunal; Nayyar, Satya Bhushan; Sachdeva, Jasmine Kaur; Kumar, Prateek

doi:10.18203/2349-3933.ijam20170020

Cited by 8 publications

(3 citation statements)

References 14 publications

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“…Another study showed that the average serum cystatin C value was 1.73 in type 2 diabetic patients with normal urinary albumin levels, while the average serum cystatin C value was 2.07 in type 2 diabetic patients with microalbuminuria. These results suggest that serum cystatin C, as a renal glomerular filtration biomarker, is an earlier indicator of diabetic nephropathy than urinary microalbumin and serum Crn [35].…”

Section: Cystatin C (Cys-c)mentioning

confidence: 82%

Research Progress on Bionic Recognition and Biosensors for the Detection of Biomarkers of Diabetic Nephropathy

Tian,

Gao,

Abdussalam

et al. 2023

Chemosensors

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Diabetic nephropathy (DN) refers to kidney damage caused by diabetes and is one of the major microvascular complications of diabetes. This disease has a certain degree of concealment in the early stage, with clinical symptoms appearing later and a higher mortality rate. Therefore, the detection of early biomarkers for DN is of great importance in reducing kidney function damage. The common biomarkers for DN mainly include glomerular and tubular lesion markers. At present, clinical diagnosis often uses a combination of multiple indicators and symptoms, and the development of a simple, efficient, and sensitive multi-marker detection platform is particularly important for the early diagnosis of DN. In recent years, with the vigorous development of various biomimetic molecular recognition technologies, biomimetic recognition biosensors (BRBS) have many advantages, such as easy preparation, low cost, high stability, and repeatability under harsh environmental conditions, and have great application potential in the analysis of DN biomarkers. This article reviews the research progress of molecularly imprinted polymers (MIPs) construction technology and aptamers assembly technology developed in the field of biomimetic sensor research in recent years, as well as the detection of DN biomarkers based on BRBS, and prospects for their development.

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Section: Cystatin C (Cys-c)mentioning

confidence: 82%

Research Progress on Bionic Recognition and Biosensors for the Detection of Biomarkers of Diabetic Nephropathy

Tian,

Gao,

Abdussalam

et al. 2023

Chemosensors

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show abstract

“…The study suggested that serum cystatin C measurement is useful for the early detection of renal impairment in a way better than serum creatinine in the patients with diabetes. 16 Another study showed that the mean serum cystatin C values in type 2 diabetes with normoalbuminuria were 1.73 and in type 2 diabetes with microalbuminuria were 2.07 17 . The results show that the serum cystatin C values were raised in the patients with microalbuminuria.…”

Section: Resultsmentioning

confidence: 99%

Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: A review of the literature

Thipsawat

2021

Diabetes and Vascular Disease Research

119

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Type 2 diabetes mellitus is a pathology of heterogeneous etiology characterized by hyperglycemia resulting from lack of insulin action, insulin secretion, or both, and the population with diabetes mellitus is predicted to be about 439 million worldwide by 2030. Prolong diabetes has been related with microvascular complications especially diabetic nephropathy. DN is the most common complication of type 2 diabetes mellitus, and it is the leading cause of end-stage renal disease worldwide. It is crucial to diagnose patients who are more sensible to develop DN for better control of the process of disease. Several factors and mechanisms contribute to the development and outcome of diabetic nephropathy. Microalbuminuria is an early marker of DN and use it as a routine for screening, but the renal damages may be happening even without microalbuminuria. There are several significant kidney damage and disease biomarkers which helps in early detection of DN. An early biomarker may allow earlier diagnosis, treatment reduces DN prevalence and slows DN progression. Therefore, this review focuses on laboratory biomarkers that are earlier, more validation of an early and specific biomarker could potentially make it possible for early diagnosis, treatment, and retardation of progression of diabetic nephropathy.

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“…1 Serum creatinine, estimated glomerular filtration rate (eGFR), blood urea, and urine albumin are typical indicators for the diagnosis and progression of diabetic nephropathy (DN). [2][3][4][5][6][7][8][9][10][11] Serum creatinine and eGFR are commonly used to evaluate renal function. However, it is noteworthy that a number of nonrenal variables, including age, weight, nutritional status, race, and gender, can affect serum creatinine levels.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of serum cystatin C levels in Type 2 diabetes mellitus with and without microalbuminuria

Blessy Susan Luke,

Anu C John

2023

Asian J Med Sci

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Background: Serum Cystatin C is elevated in diabetic patients even before the appearance of microalbuminuria and hence, it can be used as an early marker for detecting diabetic nephropathy. Aims and Objectives: The aim of the study was to compare serum Cystatin C levels in Type 2 diabetes mellitus (DM) patients with microalbuminuria and without microalbuminuria. Materials and Methods: A hospital-based and cross-sectional study conducted among 40 patients with Type 2 diabetic mellitus attending the Endocrinology OPD Medical College, Thiruvananthapuram. Informed consent was obtained. Biochemical parameters like blood glucose was estimated by hexokinase method and serum creatinine by modified Jaffe’s method using fully automated analyzer. HbA1c was determined by turbidimetric immunoinhibition method. Serum Cystatin C and microalbumin was evaluated by ELISA method. Statistical analysis of data was performed using SPSS windows version 26. Statistical tests like unpaired t-test were done to compare the study subjects and Pearson correlation was done to know the correlation between variables and P<0.05 was considered as significant. Results: In this study, all the study group had fasting blood level above 126 mg/dL with HbA1c value >6.5%. Serum creatinine value <1.4 mg/dL is considered normal. In this study group subjects, 34 (85%) had normal level of serum creatinine, while 6 (15%) 6 patients had creatinine level more than 1.4 mg/dL. Mean±SD for serum cystatin C levels in Type 2 DM patients with microalbuminuria and without microalbuminuria was 22.7±4.9 and 4.79±3.55, respectively. The serum cystatin C levels were significantly (P<0.01) higher in the microalbuminuria group than in the normoalbuminuric patients. In the present study, there was highly significant positive correlation between serum cystatin C and microalbumin (r=0.93, P<0.001. In the present study, there was highly significant positive correlation between serum cystatin C and fasting blood sugar, serum creatinine, and glycated hemoglobin in patients with microalbuminuria) than without microalbuminuria. Conclusion: Serum cystatin C levels were found to be increased in patients with Type 2 DM with microalbuminuria and can be considered as a valuable early marker of renal damage.

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Cystatin C in the early diagnosis of diabetic nephropathy and its correlation with albuminuria

Cited by 8 publications

References 14 publications

Research Progress on Bionic Recognition and Biosensors for the Detection of Biomarkers of Diabetic Nephropathy

Research Progress on Bionic Recognition and Biosensors for the Detection of Biomarkers of Diabetic Nephropathy

Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: A review of the literature

A comparative study of serum cystatin C levels in Type 2 diabetes mellitus with and without microalbuminuria

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