-Cysteine halogenides: A new family of salts with an  -cysteine⋯ -cysteinium dimeric cation

Ghazaryan, V.V.; Minkov, Vasily S.; Болдырева, Е. В.; Petrosyan, A.M.

doi:10.1016/j.molstruc.2016.05.049

Cited by 11 publications

(1 citation statement)

References 19 publications

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“…L-Cysteine (L-Cys) as a small-molecular-weight biological thiol-contained amino acid, which provides an important role in several biological processes and is essential for maintaining the appropriate redox status of proteins, cells or organisms [1,2]. It is also an active site in the catalytic function of certain enzymes called cysteine proteases and in many other peptides and proteins, and it can react with certain proteins by splitting the disulfide bonds.…”

Section: Introductionmentioning

confidence: 99%

Development of Fluorescent FRET Probes for “Off-On” Detection of L-Cysteine Based on Gold Nanoparticles and Porous Silicon Nanoparticles in Ethanol Solution

Zhang

Jia

2017

Sensors

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A new type of fluorescence “off-on” probe was designed for L-Cysteine (L-Cys) based on the fluorescence resonance energy transfer (FRET) between negatively charged amino-capped porous silicon nanoparticles (SiNPs) and positively charged citrate-stabilized Au nanoparticles (AuNPs). In this proposed FRET immunosensor, novel water-soluble amino-conjugated porous SiNPs in ethanol with excellent photoluminescence properties act as the energy donor. Excellent quenching efficiency between SiNPs-ethanol and citrate-stabilized AuNPs by electrostatic interaction via FRET provides an ideal “off-state” (turn-off). The addition of L-Cys leads to releasing the adsorbed AuNPs from the surface of SiNPs and hence the fluorescence emission of SiNPs-ethanol is restored (turn-on), which means the coordination ability of the thiols with AuNPs is stronger than that of the electrostatic interaction. The fluorescence intensity of SiNPs-AuNPs in ethanol is sensitive to L-Cys, and such a restored fluorescence is proportional to the concentration of L-Cys. The method will broadly benefit the development of a new thiol biosensor based on nanostructured porous materials, and the proposed procedure is also expected to develop a variety of functional nanoparticles to form other novel kinds of nanosensors.

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Section: Introductionmentioning

confidence: 99%