Cysteine proteinase genes in Indian strain of Haemonchus contortus

Allaie, I. M.; Prasad, A.; Sankar, M.

doi:10.1016/j.molbiopara.2014.09.003

Cited by 4 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hmcp6 gene of male H. contortus in full length with amplicon size of 1041 bp was amplified in this study with concentration of DNA in eluted fraction was 166 ng/ll which is in correlation with the work by Skuce et al (1999) and Allaie et al (2014). Skuce et al (1999) characterized a panel of six protease homologues (designated hmcp1 to 6).…”

Section: Discussionmentioning

confidence: 70%

“…Also 98.8 % sequence homology was identified by Prasad et al (2013) within the button form and linguiform morphotypes of adult female H. contortus of Indian strain. Recently Allaie et al (2014) reported that cysteine protease genes hmcp1, hmcp4, hmcp6 of UK strain and gcp7 of USA strain have been identified in different polymorphic Indian isolate of H. contortus. The 1041 bp nucleotide sequences of hmcp6 of knobbed and linguiform female revealed only 84.9 and 85 % homology, respectively with the UK strain, however 99.9 % homology was found between the two female morphotypes.…”

Section: Discussionmentioning

confidence: 99%

“…Cysteine protease genes polymorphism needs to be investigated further in the Indian strain of H. contortus about which we lack information presently other than the reports by Prasad et al (2013) and Allaie et al (2014). Therefore, it is in great need to know the presence of number of cysteine protease genes and its characterization in Indian isolates, which may give ideas for control of H. contortus in future.…”

Section: Introductionmentioning

confidence: 95%

“…Prasad et al (2013) studied the genetic polymorphism of cysteine proteases of H. contortus which confirmed the presence of hmcp4 gene of UK strain in the Indian strain. Cysteine protease genes of both UK strain and USA strain have been identified recently in different polymorphic Indian isolate of H. contortus by Allaie et al (2014).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Polymerase chain reaction (PCR) based amplification of hmcp3 and hmcp6 cysteine protease genes of Haemonchus contortus from small ruminants

et al. 2015

Self Cite

View full text Add to dashboard Cite

Haemonchus contortus is a haematophagous nematode in small ruminants population and causes anaemia, weakness and mortality especially in young animals. In the present study, hmcp3 partial gene of 836 bp and hmcp6 full length gene of 1041 bp were amplified from the cDNA of Bareilly isolate of adult male H. contortus by polymerase chain reaction. Further gene characterization and expression studies are warranted to know the immunoprophylactic potential of hmcp3 and hmcp6 proteins of H. contortus.

show abstract

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polymerase chain reaction (PCR) based amplification of hmcp3 and hmcp6 cysteine protease genes of Haemonchus contortus from small ruminants

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

Influence of immunoprotection on genetic variability of cysteine proteinases from Haemonchus contortus adult worms

Martín

Molina

Hernández

et al. 2015

International Journal for Parasitology

View full text Add to dashboard Cite

Cysteine proteases as digestive enzymes in parasitic helminths

et al. 2018

View full text Add to dashboard Cite

We briefly review cysteine proteases (orthologs of mammalian cathepsins B, L, F, and C) that are expressed in flatworm and nematode parasites. Emphasis is placed on enzyme activities that have been functionally characterized, are associated with the parasite gut, and putatively contribute to degrading host proteins to absorbable nutrients [1–4]. Often, gut proteases are expressed as multigene families, as is the case with Fasciola [5] and Haemonchus [6], presumably expanding the range of substrates that can be degraded, not least during parasite migration through host tissues [5]. The application of the free-living planarian and Caenorhabditis elegans as investigative models for parasite cysteine proteases is discussed. Finally, because of their central nutritive contribution, targeting the component gut proteases with small-molecule chemical inhibitors and understanding their utility as vaccine candidates are active areas of research [7].

show abstract

Cysteine proteinase genes in Indian strain of Haemonchus contortus

Cited by 4 publications

References 21 publications

Polymerase chain reaction (PCR) based amplification of hmcp3 and hmcp6 cysteine protease genes of Haemonchus contortus from small ruminants

Polymerase chain reaction (PCR) based amplification of hmcp3 and hmcp6 cysteine protease genes of Haemonchus contortus from small ruminants

Influence of immunoprotection on genetic variability of cysteine proteinases from Haemonchus contortus adult worms

Cysteine proteases as digestive enzymes in parasitic helminths

Contact Info

Product

Resources

About