Cystic Fibrosis-Related Diabetes with strict glycaemic control is not associated with frequent intravenous antibiotics use for pulmonary infections

Association between glucose intolerance and bacterial colonisation in an adult population with cystic fibrosis, emergence of Stenotrophomonas maltophilia

“…It is possible that different bacterial colonisation in various patient groups exposed to different risk factors and treatments could explain these different observations. Similarly to previous studies, we observed that CFRD as well as AGT are associated with increased hazard of PEx, compared to NGT [22]. One explanation could be that the presence of S. maltophilia colonisation increases the risk of PEx in dysglycemic patients specifically or that S. maltophilia colonisation increases the risk of glucose intolerance.…”

“…In that study, patients with CFRD spent 49% of the day above the 8.0 mmol/L threshold which was also identified as favourable conditions for bacterial growth [20]. Recent data suggest that worse glycemic control is associated with an increased number of days of hospitalization [21] and more PEx [22], which could explain the inverse association between post-oral glucose tolerance test (OGTT) hyperglycemia and lower pulmonary function [23,24].…”

Cystic fibrosis-related diabetes and lung disease: an update

“…CFRD has also been shown to play a crucial role in the rate of lung function decline and mortality in patients with CF [38][39][40][41][42]. Even in patients with a normal OGTT, early glucose abnormalities have been shown to be associated with more severe lung disease.…”

Cystic fibrosis related diabetes: Medical management

“…This increases the viscosity of airway surface liquid and increases bacterial colonization and pulmonary exacerbation [41]. However, in a cohort with strict glycaemic control, there was no difference found in the rate of pulmonary exacerbation in CF patients with and without CFRD [42], implying that insulin treatment of CFRD reduces complication rates.…”