Cystic infection of the liver in a maintenance haemodialysis patient

Keven, Kenan; Bengisun, J. Sedef; Altuntaş, Fevzi; Akar, Harun; Nergızoğlu, Gökhan; Kutlay, Sim; Duman, Neval; Erbay, Bülent

doi:10.1093/ndt/16.4.859

Cited by 10 publications

(7 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As a consequence, even though hepatic capillariasis is an uncommon infection, it should be taken into consideration as a fatal zoonotic parasite. Zoonotic cases have been reported in humans worldwide and children below the age of 8 years are in the highest risk group due to their habit of geophagy (1,5). Control of rodent populations, sanitary disposal of dead animals, and improved hygiene should be considered for public health.…”

Section: Resultsmentioning

confidence: 99%

“…This capillariid nematode infects the hepatic parenchyma of rodents (primary host) and various other mammals including rabbits, pigs, opossums, squirrels, foxes, cats, dogs, and human beings (1)(2)(3)(4). Human capillariasis caused by C. hepatica poses a significant risk because the disease may become fatal due to severe liver damage (1,5). More than 160 human infections caused by C. hepatica have been reported worldwide (1).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Severe granulomatous hepatitis caused by Capillaria hepatica in a puppy

Demirer¹,

Akkoç²,

Şenlik³

et al. 2018

Turk J Vet Anim Sci

View full text Add to dashboard Cite

This report describes the inflammation caused by Capillaria hepatica in the liver of a female stray dog of approximately 2 months old for the first time in Turkey. Histopathological examination revealed severe granulomatous hepatitis with occasional adult nematodes and abundant eggs in the hepatic parenchyma. The present case differs from the other capillariasis cases by the age of the dog and the presence of mature female parasites and severe inflammation.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Severe granulomatous hepatitis caused by Capillaria hepatica in a puppy

Demirer¹,

Akkoç²,

Şenlik³

et al. 2018

Turk J Vet Anim Sci

View full text Add to dashboard Cite

show abstract

“…They are common and benign, usually asymptomatic, and require no treatment [15,25]. They occasionally resolve spontaneously, but can also cause serious complications [4][5][6][7][8][9][10][11][12][13][14][16][17][18][19][20][21][22][23]26]. Fong et al reviewed the literature on hemorrhagic hepatic cysts [27].…”

Section: Discussionmentioning

confidence: 99%

“…Most benign, nonparasitic hepatic cysts are found incidentally and are usually asymptomatic. However, complications such as obstructive jaundice [4], rupture [5][6][7][8][9], intracystic hemorrhage [9][10][11][12][13][14][15], and infection [16][17][18][19][20][21][22][23][24] can occasionally occur. Most patients with a hemorrhagic hepatic cyst present with abdominal pain (80%), while some cases are asymptomatic at the time of presentation [15].…”

Section: Introductionmentioning

confidence: 99%

An Asymptomatic Hemorrhagic Hepatic Cyst with Solid Contents

Kondo¹,

Yoshida²,

Hirakata³

et al. 2014

Int J Gastroenterol Disord Ther

View full text Add to dashboard Cite

We describe a patient who had an asymptomatic hemorrhagic hepatic cyst with solid contents that mimicked a malignancy. An 85-year-old woman was referred to our hospital because a hypoechoic mass was detected. She had no complications. The past medical history included hypertension and left femoral artery aneurysm. The results of initial laboratory tests were as follows: serum aspartate aminotransferase, 28 IU/L; serum alanine aminotransferase, 23 IU/L; serum C-reactive protein, 0.11 mg/dL; and serum hemoglobin concentration, 13.1 g/dL. The serum platelet count (17.3×104/μL) was slightly decreased. The serum concentration of carcinoembryonic antigen was 3.0 ng/mL, that of CA19-9 was 12.2 u/ml, and that of AFP was 3.8 ng/ml. The serum concentration of hyaluronic acid (147 ng/mL) was elevated. Hepatitis B virus antigen and hepatitis C virus antibody were negative. Ultrasonography revealed a protruding hypoechoic mass, 6 cm in diameter, with a central isoechoic structure in segment 7, accompanied by multiple hepatic cysts. The edge of the liver was dull, and the liver parenchymal echo was mildly rough. Computed tomography (CT) showed a slightly high-density area with calcification of the margin. Magnetic resonance imaging revealed a hypointense lesion with central hyperintensity on T1-weighted sequences and hyperintensity on T2-weighted sequences. On positron emission tomography-CT, there was no uptake of fluorodeoxyglucose in the liver. We diagnosed an old hemorrhagic cyst or abscess, but could not rule out a malignant neoplasm because of the damaged liver. A right lateral sectionectomy was therefore performed. The resected specimen had black solid contents, and the capsule lacked fluid. Pathological examination revealed an old hemorrhage with a thick fibrous capsule without epithelial components. The liver showed mild fibrosis with fatty changes. The lesion was considered an old hemorrhagic hepatic cyst because a nearby hepatic cyst had simple columnar epithelium.

show abstract

“…No interior dos ductos biliares e em meio ao tecido conjuntivo, observaram-se numerosas estruturas parasitárias, com formato de barril bioperculado, compatível com ovos de Capillaria hepatica (Figura 4A). Os diâmetros longitudinal e transversal de 23 ovos foram aferidos e as médias e desvio padrão obtidos foram 42,27 (4,12) µm e 20,87 (1,96) µm, respectivamente (Figura 4B). Os hepatócitos estavam moderadamente degenerados, mesclando traços de colestase e leve hemorragia periférica.…”

Section: Casounclassified

True Infection by Capillaria hepatica in a Dog

Oliveira

Madeira

Soares

et al. 2021

Acta Scientiae. Vet.

View full text Add to dashboard Cite

Background: Capillaria hepatica is a nematode, zoonotic, with worldwide distribution. The main hosts are rodents, nevertheless other mammals can be affected. Although the parasite has high affinity for the liver, it rarely causes a hepatic disease in domestic animals and humans. The diagnosis is difficult and usually a biopsy is required. The treatment is difficult and is based in anti-helminthic and corticoid, but prevention is the best strategy against the disease. The aim of the present report is to describe a case of hepatic capillariosis in a dog approaching the clinical signs, diagnosis and therapeutic. Case: A 12-year-old Brazilian Terrier bitch, with a history of visit to the farm and regular hunting of rats, frogs, birds and other wild animals, was attended with hyporexia and apathy. At the physical exam the dog presented elevation of rectal temperature, intense jaundice and abdominal pain. In the biochemical exams was noticed a slight increase in globulins and a sharp increase in alkaline phosphatase (AP), total, direct and indirect bilirubin, suggesting a liver injury. In the ultrasonographic exam, hepatomegaly with dispersed hyperechoic areas were observed, suggesting hepatic steatosis. The patient was treated with ursodesoxicolic acid and S-adenosil metionin for 30 consecutive days, showing a clinic improvement. Two months after the end of the treatment the animal worsened, showing jaundice, ascites, motor incoordination, weakness, difficulty in food and water ingestion and changes in the mental state. In the complete blood count was observed a macrocytic hypochromic regenerative anemia, leukocytosis with neutrophilia and monocytosis and thrombocytopenia. In biochemical exams was detected decrease in creatinine and albumin and increase in alanine aminotransferase and AP, suggesting hepatopathy by biliary obstruction. There were performed exams for leishmania and ehrlichiosis that tested negative. In the ultrasonographic exam it was noticed that the liver had the same alterations and the presence of free fluid in the abdominal cavity. Due to the deterioration of the clinical picture a blood transfusion was necessary, however the patient worsened and presented respiratory difficulty for a bilateral pleural effusion. Then, the fluid was drained and a treatment with S-adenosil metionin, silymarin, ursodesoxicolic acid, doxycycline and prednisolone was started. After 17 days, a hepatic biopsy was performed, but the patient died at the surgery desk. Samples from the liver were collected for histopathologic exam. The diagnosis was confirmed in hepatic capillariosis and periportal chronic hepatitis, with the visualization of numerous parasites structures with bioperculated barrel shape. Discussion: Due to the nonspecific clinical alterations observed in the patient and the low prevalence of C. hepatica in domestic animals, there was a difficulty in the diagnosis which lead to a symptomatic, nonspecific and inefficient treatment that culminate with the death of the patient. The histopathologic exam of the liver is the best manner to find the correct diagnosis of C. hepatica infection, once the parasites eggs remains in the liver parenchyma wrapped by fibrosis and aren´t eliminate in the feces. The eggs elimination in the environment just occur after the death of the animal. Although there didn't exist a consensus about hepatic capillariosis treatment yet, if the diagnosis were done earlier, a specific treatment with better chances of a good result could be performed. We concluded that hepatic capillariosis should be included in differential diagnosis for patients with hepatic syndrome, mainly if the animal had a hunting habit and if it had access to surroundings with high rats’ infestation.

show abstract

Cystic infection of the liver in a maintenance haemodialysis patient

Cited by 10 publications

References 6 publications

Severe granulomatous hepatitis caused by Capillaria hepatica in a puppy

Severe granulomatous hepatitis caused by Capillaria hepatica in a puppy

An Asymptomatic Hemorrhagic Hepatic Cyst with Solid Contents

True Infection by Capillaria hepatica in a Dog

Contact Info

Product

Resources

About