Cystic Leiomyosarcoma of the Kidney: An Unusual Clinical Presentation

Dominici, A; Mondaini, Nicola; Nesi, Gabriella; Travaglini, F; Cello, V. Di; Rizzo, M.

doi:10.1159/000064886

Cited by 18 publications

(17 citation statements)

References 2 publications

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“…Because of this, 5-year survival rate is about 29-36%. Most patients die within 1 year after time of diagnosis because of poor prognosis [5]. No therapeutic protocol has been defined for adjuvant chemotherapy but sunitinib, a tyrosine kinase inhibitor, has been shown to be beneficial in the phase-II studies [6].…”

Section: Discussionmentioning

confidence: 99%

High-Grade Primary Leiomyosarcoma of the Kidney

Ozturk

2014

World J Nephrol Urol

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Leiomyosarcomas account for 0.8 to 2.7% of all malignant renal tumors. Like the leiomyomas, the leiomyosarcomas originate from the cells of the renal capsule, pelvis renalis, the calyces and smooth muscle of the blood vessels. They are two-folds more common in women and most frequently seen in the fourth and sixth decades. They are solitary lesions. Their major symptoms are pain, palpable mass and hematuria. Clinical, radiological and pathological findings of a 51 years old patient presenting with diagnosed flank pain and nausea and diagnosed as having high-grade primary renal leiomyosarcomas were evaluated under the light of current literature.

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Section: Discussionmentioning

confidence: 99%

High-Grade Primary Leiomyosarcoma of the Kidney

Ozturk

2014

World J Nephrol Urol

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“…These tumors usually present with flank pain, hematuria (microscopic or macroscopic) and an abdominal mass, thus mimicking renal cell carcinoma. Radiographic findings are non-specific and the diagnosis is usually made postoperatively [7]. Renal leiomyosarcoma, like other types of sarcomas, tend to displace rather than invade the parenchyma, and it is characterized by rapid growth rate, frequent metastasis, and high local and systemic recurrence rates [8].…”

Section: Discussionmentioning

confidence: 99%

Case report: Good prognosis in leiomyosarcoma of the kidney

et al. 2007

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Sarcomas represent 1-2% of all malignant renal tumors in adults, with an incidence that increases with advancing age. Renal sarcoma is less common, but more lethal than sarcoma of any other genitourinary site. The common signs and symptoms associated with renal sarcoma in adults include palpable mass, abdominal or flank pain and hematuria similar to those seen with large, rapidly growing renal cell carcinomas. Usually, radical nephrectomy remains the treatment of choice for these tumors, which exhibits an aggressive biological behavior and an unfavorable prognosis. We describe an unusual case of renal leiomyosarcoma that underwent nephron sparing surgery, in a 55-year-old white woman, who had a renal mass for 3 years. The size of the renal mass did not change during this period and no distant metastasis occurred. The patient is still alive without any symptoms of relapse.

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“…Irradiation and chemotherapy may not appear to alter the clinical course [10]. But recent reports of chemo sensitivity testing in soft tissue sarcomas are encouraging and are being used to create sensitivity and resistance profiles of established and new cytotoxic agents [11].…”

Section: Discussionmentioning

confidence: 99%

“…In general, these tumors have a poor prognosis although occasionally long-term survivors are reported. Size less than 5 cm, low histological grade, absence of lymph node metastasis and radical surgeries are all associated with a better prognosis [10]. Despite radical nephrectomy, the tumors can run an aggressive clinical course and early local and distant recurrences are common.…”

Section: Discussionmentioning

confidence: 99%

Leiomyosarcoma of kidney – a case report with long term result after radiotherapy and chemotherapy

et al. 2007

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Leiomyosarcoma of the kidney is a rare entity with poor prognosis. Among renal sarcomas, it is the most common histologic subtype amounting to 50-60% of all cases. The tumors usually arise from either the renal capsule or smooth muscle tissue in the renal pelvic wall. We describe a case of renal leiomyosarcoma that presented with history of left flank pain. Physical examination was normal. Abdominal ultrasound showed a solid lesion of 38 x 36 mm arising from the left kidney. Intravenous urography showed cut off of both major and minor calyces of the left kidney from its pelvis with a normal right kidney. Exploratory laparotomy revealed a well-encapsulated mass confined to the renal parenchyma for which radical nephrectomy was performed. Histopathology showed a Grade I leiomyosarcoma arising from the renal capsule. Adjuvant chemotherapy and sandwich radiotherapy was given and he is disease free after six and half years of follow up. The rarity of this disease, its severity and poor prognosis, uncommon form of presentation, resulting delay in diagnosis and difficulty in management is highlighted and reported.

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Cystic Leiomyosarcoma of the Kidney: An Unusual Clinical Presentation

Cited by 18 publications

References 2 publications

High-Grade Primary Leiomyosarcoma of the Kidney

High-Grade Primary Leiomyosarcoma of the Kidney

Case report: Good prognosis in leiomyosarcoma of the kidney

Leiomyosarcoma of kidney – a case report with long term result after radiotherapy and chemotherapy

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