Cystic Parotid Lesions in Patients at Risk for the Acquired Immunodeficiency Syndrome

Finfer, Michael; Schinella, Roger; Rothstein, Stephen G.; Persky, Mark S.

doi:10.1001/archotol.1988.01860230084030

Cited by 68 publications

(41 citation statements)

References 13 publications

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“…43,44,50 BENIGN LYMPHOEPITHELIAL CYSTIC LESIONS Salivary gland enlargement associated with a significant lymphoid infiltrate was recognized early in the HIV epidemic. 51,52 Because the lymphoid tissue usually exhibits morphologic and immunophenotypic features similar to those seen in FFH and the lesions often occur in association with enlarged lymph nodes, benign lymphoepithelial cystic lesions are thought to represent a manifestation of persistent, generalized lymphadenopathy. 51,53,54 Known by several names, including benign lymphoepithelial lesion, benign lymphoepithelial cyst, cystic lymphoid hyperplasia, and HIV-related salivary gland disease, this lesion most commonly arises in the parotid gland where it is thought to occur in 3% to 6% of adults and 1% to 10% of children infected with HIV.…”

Section: Many Cd8mentioning

confidence: 99%

Lymphoid Proliferations Associated With Human Immunodeficiency Virus Infection

Chadburn

Abdul-Nabi

Teruya

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Individuals who are immune deficient are at an increased risk for developing lymphoproliferative lesions and lymphomas. Human immunodeficiency virus (HIV) infection is 1 of 4 clinical settings associated with immunodeficiency recognized by the World Health Organization (WHO) in which there is an increased incidence of lymphoma and other lymphoproliferative disorders. Objectives.—To describe the major categories of benign lymphoid proliferations, including progressive HIV-related lymphadenopathy, benign lymphoepithelial cystic lesions, and multicentric Castleman disease, as well as the different types of HIV-related lymphomas as defined by the WHO. The characteristic morphologic, immunophenotypic, and genetic features of the different entities will be discussed in addition to some of the pathogenetic mechanisms. Data Sources.—The WHO classification of tumors of hematopoietic and lymphoid tissues (2001 and 2008), published literature from PubMed (National Library of Medicine), published textbooks, and primary material from the authors' current and previous institutions. Conclusions.—HIV infection represents one of the clinical settings recognized by the WHO in which immunodeficiency-related lymphoproliferative disorders may arise. Although most lymphomas that arise in patients with HIV infection are diffuse, aggressive B-cell lesions, other lesions, which are “benign” lymphoid proliferations, may also be associated with significant clinical consequences. These lymphoproliferations, like many other immunodeficiency-associated lymphoproliferative disorders, are often difficult to classify. Studies of HIV-associated lymphoid proliferations will continue to increase our understanding of both the immune system and lymphomagenesis.

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Section: Many Cd8mentioning

confidence: 99%

Lymphoid Proliferations Associated With Human Immunodeficiency Virus Infection

Chadburn

Abdul-Nabi

Teruya

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

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“…HIV-associated cystic lymphoid hyperplasia shows dense lymphoid tissue (that can easily be mistaken for low-grade mucosa-associated lymphoid tissue lymphoma) abutting the epithelial lining of the cyst, which invariably is stratified and squamous in type and classically affects the parotid glands, although no cases have been described in the lacrimal gland [4]. In our case, the cyst was supported by a distinct band of fibrosis, and the lymphoid tissue did not border the epithelial lining.…”

Section: Discussionmentioning

confidence: 99%

Lacrimal Gland Intra-Lobular Duct Cysts Associated with Focal Vasculitis

2015

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Purpose: Description of the clinical and histopathological features of unusual lacrimal gland intra-glandular duct cysts. Procedures: A 38-year-old male presented with bilateral upper lid lumpiness, which was worse on the left. Computed tomography scan showed bilateral multiple lacrimal gland cysts, which were larger on the left compared to the right. After two unsuccessful attempts to excise the largest cyst on the left side, it was removed at the third attempt using a novel technique that incorporated the use of fibrin glue to fill the remaining cavity. Results: The microscopy of the left-sided cyst comprised a cavity containing fibrin glue, lined by intra-lobular lacrimal gland duct epithelium. The cyst wall contained reactive lymphoid aggregates, plasma cells and eosinophils associated with fibrosis. Focally, there were small vessels affected by an acute vasculitis associated with eosinophils and a granulomatous component. Conclusions: We ascribe the cyst formation to the effects of tractional fibrosis secondary to focal vasculitis and to obstructive fibrosis of the lacrimal ductules. This case also described a novel use of Tisseel fibrin glue to assist intact removal of a lacrimal gland cyst.

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“…in a degenerated necrotic lymph node [4]. Hence excisional biopsy by superficial parotidectomy is the standard diagnostic and therapeutic intervention for such cysts [45]. If the diagnosis of a parotid branchial cyst is certain, then simple partial lateral superficial parotidectomy with preservation of the facial nerve is recommended, perhaps via a modified retroauricular incision [22].…”

Section: Discussionmentioning

confidence: 99%

Branchial cysts within the parotid salivary gland

et al. 2012

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Cystic lesions within the parotid gland are uncommon and clinically they are frequently misdiagnosed as tumours. Many theories have been proposed as to their embryological origin. A 20-year retrospective review was undertaken of all pathological codes (SNOMED) of all of patients presenting with any parotid lesions requiring surgery. After analysis seven subjects were found to have histopathologically proven parotid branchial cysts in the absence of HIV infection and those patients are the aim of this review. Four of the most common embryological theories are also discussed with regard to these cases, as are their management.

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Cystic Parotid Lesions in Patients at Risk for the Acquired Immunodeficiency Syndrome

Cited by 68 publications

References 13 publications

Lymphoid Proliferations Associated With Human Immunodeficiency Virus Infection

Lymphoid Proliferations Associated With Human Immunodeficiency Virus Infection

Lacrimal Gland Intra-Lobular Duct Cysts Associated with Focal Vasculitis

Branchial cysts within the parotid salivary gland

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