Cystic Renal Cell Carcinoma: A Report on Outcomes of Surgery and Active Surveillance in Patients Retrospectively Identified on Pretreatment Imaging

Kashan, Mahyar; Ghanaat, Mazyar; Hötker, Andreas M.; Düzgöl, Cihan; Sánchez, Alejandro; DiNatale, Renzo G.; Blum, Kyle A.; Becerra, Maria F.; Manley, Brandon; Casuscelli, Jozefina; Chiok, Michael; Coleman, Jonathan; Russo, Paul; Tickoo, Satish K.; Akın, Oğuz; Hakimi, A. Ari

doi:10.1016/j.juro.2018.02.3087

Cited by 34 publications

(34 citation statements)

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“…The renal cell (RCC) [15] [16], led to the resection of numerous benign masses and indolent cancers, without benefiting the patients. This may be particularly true for cystic kidney cancers, which are less likely to be malignant and, which are cancerous, are more likely to be indolent and have a better prognosis [17] [18] [19].…”

Section: Discussionmentioning

confidence: 99%

Atypical Renal Cysts: Is MRI a Compulsory Examination in 2020 before Therapeutic Management?

Ziani¹,

Ibrahimi²,

Dergamoun³

et al. 2020

OJU

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Section: Discussionmentioning

confidence: 99%

Atypical Renal Cysts: Is MRI a Compulsory Examination in 2020 before Therapeutic Management?

Ziani¹,

Ibrahimi²,

Dergamoun³

et al. 2020

OJU

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“…New clinical and radiological parameters are needed to distinguish the malignant Bosniak 3 lesions from the benign ones. For this purpose, studies investigating the importance of lesion size, nodularity, and cyst ratio have been published recently [3-5]. The Bosniak classification is an important method to predict malignancy rather than a comprehensive management algorithm that applies to the biological behavior of lesions, such as aggressiveness which affects the patient’s prognosis.…”

Section: Introductionmentioning

confidence: 99%

Predictive Value of Additional Clinical and Radiological Parameters for Discrimination of Malignancy in Bosniak 3 Cysts

Şefik¹,

Bozkurt²,

Oğuzdoğan³

et al. 2020

Urol Int

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Introduction: Almost half of the cystic renal lesions are still overdiagnosed and overtreated. New clinical and radiological parameters are needed to distinguish the malignant Bosniak 3 lesions from the benign ones. We aimed to evaluate the clinical and radiological parameters that may be related to malignancy risk for Bosniak category 3 renal cysts. Materials and Methods: Patients who underwent surgical resection of a histopathologically confirmed Bosniak 3 renal cyst between March 2007 and September 2019 were evaluated. Two experienced uro-radiologists have reevaluated the last preoperative computed tomography and/or MRI images of the patients and reclassified the lesions according to the Bosniak classification. They also reported cystic features such as nodularity, septation, focal thickening, enhancement, and calcification. Clinical, pathological, and oncological outcomes were recorded. Then patients were divided into 2 groups as Group 1 (benign pathology) and Group 2 (malignant pathology) according to final histopathological report. Results: A total of 79 patients were included in this study. Mean follow-up time was 47 ± 34 months. There were 30 patients in Group 1 and 49 patients in Group 2. Hypertension (p = 0.001) and smoking history (p = 0.008) were more common in malignant group. Among the radiological findings, lower tumor diameter (p = 0.024), presence of cyst wall enhancement (p = 0.025), presence of nodularity (p = 0.002), and presence of focal thickening (p = 0.031) were found to be statistically significant for malignancy. Most of the tumors were at pathological T1 stage and Fuhrmann Grade 1–2. Only nodularity was found to be independent predictive factor for malignancy in multivariate analysis. Conclusion: Clinical factors including hypertension and smoking, radiological factors including lower lesion size, cyst wall enhancement, nodularity, and focal thickening were predictors for malignancy of Bosniak 3 cysts.

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“…Não foi encontrada recidiva tumoral local ou a distância (Smith, Remer et al 2012). Outros estudos, mostram que os CRCs com confirmação histológica de malignidade são menos agressivos e apresentam sobrevida câncer específica superior às pequenas massas renais sólidas (PMRS) (Webster, Thompson et al 2007, Reese, Johnson et al 2014, Bhatt, Jewett et al 2016, Kashan, Ghanaat et al 2018, Lam and Kapoor 2018. Dentre as opções de tratamento disponíveis, vigilância ativa (VA), métodos de ablação e cirurgia, esta última é a que se associa às maiores taxas de complicações, principalmente em pacientes com comorbidades (Smith, Allen et al 2015).…”

Section: Tratamento E Prognóstico Dos Cistos Renais Complexos Operadosunclassified

“…Os principais critérios propostos para a VA das massas renais são: pacientes idosos, frágeis, com comorbidades, curta expectativa de vida ou pacientes com alterações na função renal (Berland, Silverman et al 2010) (Silverman, Israel et al 2008) Embora, apresentem altas taxas de malignidade, os resultados da VA para os CRCs Bk (III e IV) são compatíveis com lesões de comportamento indolente. As taxas de metástases e óbitos pela doença são muito baixas, variando de (0 % a 1%) na maioria dos estudos com seguimento mínimo de 2 anos (Mousessian, Yamauchi et al 2017) (Kashan, Ghanaat et al 2018) (Lam and Kapoor 2018) (Pruthi, Liu et al 2018) (Park, Lee et al 2017). Tal fato, corrobora o emprego da VA para os CRCs (Chandrasekar, Ahmad et al 2018)…”

Section: Vigilância Ativa: Em Cistos Renais Complexos Bk (Iii E Iv)unclassified

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Cistos renais bosniak 3 e 4: impacto da vigilância ativa nos escores nefrométricos

Machado¹

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A minha amada esposa Andreza Vargas da Silva, pelo incentivo, compreensão e apoio em todos os momentos difíceis, acreditando sempre no meu potencial. Aos meus queridos filhos, Manuela Vargas Machado e Augusto Vargas Machado, (presentes de Deus). Pela alegria que me causam, e pelo amor inexplicável e sem fim. Aos meus pais José Dias Machado (in memoriam) e especialmente minha mãe Maria Ribeiro Machado pelo amor incondicional, pelo exemplo de vida e abdicação total de sua vida pessoal em prol da família. Aos meus queridos irmãos, Denis e Marcos, pela fraternal convivência. Às minhas queridas cunhadas, Lívia e Mary, pelo respeito e carinho de irmãos. Aos meus sobrinhos queridos, Sofia, João Vitor, Antônio e Maria Clara, pela alegria que trazem as nossas vidas. Aos meus avós Braulo Dorício Ribeiro (in memoriam) e Augusta Alves Ribeiro (in memoriam), pelos ensinamentos íntegros, acolhimento e carinho em momentos cruciais da minha vida, sinalizando sempre o caminho correto. Aos tios, pelo suporte e confiança. Aos primos, pelo afeto de irmãos. A minha sogra Arlinda Vargas Alves da Silva e sogro Agnaldo Alves da Silva, pela consideração, respeito e afago com os quais me receberam. Aos meus amigos e meus colegas do Hospital de Câncer de Barretos, pela amizade e companheirismo, pessoas que de alguma forma participaram da realização deste trabalho, especialmente os do Departamento de Uro-oncologia: Dr.

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Cystic Renal Cell Carcinoma: A Report on Outcomes of Surgery and Active Surveillance in Patients Retrospectively Identified on Pretreatment Imaging

Abstract: Patients with unifocal cystic renal cell carcinoma evaluated using a standardized radiological threshold of greater than 50% cystic had an excellent prognosis on active surveillance and after surgical resection.

Cited by 34 publications

References 21 publications

Atypical Renal Cysts: Is MRI a Compulsory Examination in 2020 before Therapeutic Management?

Atypical Renal Cysts: Is MRI a Compulsory Examination in 2020 before Therapeutic Management?

Predictive Value of Additional Clinical and Radiological Parameters for Discrimination of Malignancy in Bosniak 3 Cysts

Cistos renais bosniak 3 e 4: impacto da vigilância ativa nos escores nefrométricos

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