Cystine proportion regulates fate of polypeptide nanogel as nanocarrier for chemotherapeutics

Feng, Xiangru; Xu, Weiguo; Xu, Xiaoru; Gao, Li; Ding, Jianxun; Chen, Xuesi

doi:10.1007/s11426-020-9884-6

Cited by 57 publications

(34 citation statements)

References 34 publications

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“…After endocytosis of nanomedicine by cancer cells, under conditions of high GSH, disulfide bonds are reduced to a sulfhydryl group as a reduction response, causing the polymer to decompose and release the loaded drug ( Zhao et al, 2017 ; Hu et al, 2018 ; Yang et al, 2021 ). With the rapid development of reduction-sensitive and reversible cross-linked polymers in the past few years, various reduction-sensitive systems have shown significant activity against different malignant tumors ( Meng et al, 2009 ; Cheng et al, 2011 ; Feng et al, 2020 ). Bladder cancer cells contain a high concentration of GSH that can restore the microenvironment.…”

Section: Non-specific Targeted Therapeutic Nanocarriers For Treatment Of Bladder Cancermentioning

confidence: 99%

Functional Nanomedicines for Targeted Therapy of Bladder Cancer

et al. 2021

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Bladder cancer is one of most common malignant urinary tract tumor types with high incidence worldwide. In general, transurethral resection of non-muscle-invasive bladder cancer followed by intravesical instillation of chemotherapy is the standard treatment approach to minimize recurrence and delay progression of bladder cancer. However, conventional intravesical chemotherapy lacks selectivity for tumor tissues and the concentration of drug is reduced with the excretion of urine, leading to frequent administration and heavy local irritation symptoms. While nanomedicines can overcome all the above shortcomings and adhere to the surface of bladder tumors for a long time, and continuously and efficiently release drugs to bladder cancers. The rapid advances in targeted therapy have led to significant improvements in drug efficacy and precision of targeted drug delivery to eradicate tumor cells, with reduced side-effects. This review summarizes the different available nano-systems of targeted drug delivery to bladder cancer tissues. The challenges and prospects of targeted therapy for bladder cancer are additionally discussed.

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Section: Non-specific Targeted Therapeutic Nanocarriers For Treatment Of Bladder Cancermentioning

confidence: 99%

Functional Nanomedicines for Targeted Therapy of Bladder Cancer

et al. 2021

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“…Feng et al ( Feng et al, 2021 ) synthesized three kinds of mPEG-P (LP-co-LC) nanogels with different l -cysteine scales, including mPEG-P (LP 10 -co -LC 15 ) (NG 10-15 ), mPEG-P (LP 10 -co-LC 10 ) (NG 10-10 ), and mPEG-P (LP 10 -co-LC 5 ) (NG 10-5 ). They evaluated the pharmacokinetic properties, tissue distribution, and antitumor efficiency of these nanogels with similar surface charge, morphology, and reductive reaction characteristics.…”

Section: Single Stimulus–responsive Nanogelsmentioning

confidence: 99%

“…In addition, among these three preparations, NG 10-5 /DOX has optimal antitumor efficacy on 4T1 breast cancer. On this basis, Feng et al ( Feng et al, 2021 ) used mPEG-P (LP-co-LC) to co-encapsulate DOX and 1-methyl-DL-tryptophan (1 MT) referred as NG/(DOX + 1 MT) for 4T1 breast cancer treatment. By reducing the dose of DOX required to induce immunogenic cell death–inducing (ICD), the author achieved the goal of reducing the toxicity of mice and inducing the ICD of cancer cells at the same time.…”

Section: Single Stimulus–responsive Nanogelsmentioning

confidence: 99%

Tumor Microenvironment–Responsive Polypeptide Nanogels for Controlled Antitumor Drug Delivery

et al. 2021

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Tumor microenvironment–responsive polypeptide nanogels belong to a biomaterial with excellent biocompatibility, easily adjustable performance, biodegradability, and non-toxic properties. They are developed for selective delivery of antitumor drugs into target organs to promote tumor cell uptake, which has become an effective measure of tumor treatment. Endogenous (such as reduction, reactive oxygen species, pH, and enzyme) and exogenous (such as light and temperature) responsive nanogels can release drugs in response to tumor tissues or cells to improve drug distribution and reduce drug side effects. This article systematically introduces the research progress in tumor microenvironment–responsive polypeptide nanogels to deliver antitumor drugs and provides a reference for the development of antitumor nanoformulations.

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“…Nanoagents are a type of nanomaterials that are widely used in biological research to deliver drugs [ [1] , [2] , [3] , [4] ], and one of such nanoagents is porous iron oxide nanoagents (PIONs). PIONs are used as a vehicle because of their specific magnetic and photothermal properties [ [5] , [6] , [7] , [8] , [9] , [10] ].…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic and magnetic resonance imaging-based gene and photothermal therapy using mesoporous nanoagents

Huang

Yuan

et al. 2022

Bioactive Materials

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The integration of photothermal therapy (PTT) with gene therapy (GT) in a single nanoscale platform demonstrates great potential in cancer therapy. Porous iron oxide nanoagents (PIONs) are widely used as magnetic nanoagents in the drug delivery field and also serve as a photothermal nanoagent for photothermal therapy. However, the therapeutic efficacy of PIONs-mediated GT has not been studied. The long noncoding RNA (lncRNA) CRYBG3 (LNC CRYBG3), a lncRNA induced by heavy ion irradiation in lung cancer cells, has been reported to directly bind to globular actin (G-actin) and cause degradation of cytoskeleton and blocking of cytokinesis, thus indicating its potential for use in GT by simulating the effect of heavy ion irradiation and functioning as an antitumor drug. In the present study, we investigated the possibility of combining PIONs-mediated PTT and LNC CRYBG3-mediated GT to destroy non-small cell lung cancer (NSCLC) cells both in vitro and in vivo . The combination therapy showed a high cancer cell killing efficacy, and the cure rate was better than that achieved using PTT or GT alone. Moreover, as a type of magnetic nanoagent, PIONs can be used for magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) both in vitro and in vivo . These findings indicate that the new combination therapy has high potential for cancer treatment.

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Cystine proportion regulates fate of polypeptide nanogel as nanocarrier for chemotherapeutics

Cited by 57 publications

References 34 publications

Functional Nanomedicines for Targeted Therapy of Bladder Cancer

Functional Nanomedicines for Targeted Therapy of Bladder Cancer

Tumor Microenvironment–Responsive Polypeptide Nanogels for Controlled Antitumor Drug Delivery

Photoacoustic and magnetic resonance imaging-based gene and photothermal therapy using mesoporous nanoagents

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