Abstract:For the first time, in vivo utilization of two highly soluble and stable cystine containing synthetic short chain peptides, N,N'-bis-L-alanyl-L,L-cystine and N,N'-bis-glycyl-L,L-cystine, was investigated in adult rats. Within 5 min after an intravenous bolus, blood samples were drawn (inferior vena cava) and plasma amino acid and peptide levels were determined using RP-HPLC (precolumn derivatization with 1-dimethylaminonaphthalene-5-sulfonylchloride). Both peptides were rapidly cleared from plasma (estimated e… Show more
“…N,N-bis-L-alanyl-L,L-cystine and N,N-bis-L-glycyl-L,L-cystine are rapidly uti lized after bolus injection in the rat (162,187). taking into account the activity of membrane peptidases of liver and muscle.…”
“…N,N-bis-L-alanyl-L,L-cystine and N,N-bis-L-glycyl-L,L-cystine are rapidly uti lized after bolus injection in the rat (162,187). taking into account the activity of membrane peptidases of liver and muscle.…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.