Cystoscopic optical coherence tomography for urinary bladder imaging in vivo

Wang, Z. G.; Adler, Henry J.; Chan, David Y.; Jain, Ankur; Xie, Huikai; Wu, Z. L.; Pan, Yingtian

doi:10.1117/12.649100

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…The animal model employed in this study has been reported previously; 23 therefore, only a brief summary is provided here. Because of lack of a large animal bladder cancer model suitable for testing OCT endoscopes for in vivo imaging, the porcine acute bladder inflammation model was modified based on a well-developed rat bladder irritation model.…”

Section: Animal Model For In Vivo Sdeoct Studymentioning

confidence: 99%

“…20 and 21͒, and spectral secondharmonic generation 22 OCT to enhance image contrast in biological tissue. In addition to technological advances, clinical applications of SDOCT have already been performed in various tissues, including eye, 15 esophagus, 14 and urinary bladder, 23 demonstrating dramatic improvement on image fidelity and imaging rate.…”

Section: Introductionmentioning

confidence: 99%

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In vivo bladder imaging with microelectromechanical-systems-based endoscopic spectral domain optical coherence tomography

et al. 2007

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We report the recent technical improvements in our microelectromechanical systems (MEMS)-based spectral-domain endoscopic OCT (SDEOCT) and applications for in vivo bladder imaging diagnosis. With the technical advances in MEMS mirror fabrication and endoscopic light coupling methods, the new SDEOCT system is able to visualize morphological details of the urinary bladder with high image fidelity close to bench-top OCT (e.g., 10 mum12 mum axial/lateral resolutions, >108 dB dynamic range) at a fourfold to eightfold improved frame rate. An in vivo animal study based on a porcine acute inflammation model following protamine sulfate instillation is performed to further evaluate the utility of SDEOCT system to delineate bladder morphology and inflammatory lesions as well as to detect subsurface blood flow. In addition, a preliminary clinical study is performed to identify the morphological features pertinent to bladder cancer diagnosis, including loss of boundary or image contrast between urothelium and the underlying layers, heterogeneous patterns in the cancerous urothelium, and margin between normal and bladder cancers. The results of a human study (91% sensitivity, 80% specificity) suggest that SDEOCT enables a high-resolution cross-sectional image of human bladder structures to detect transitional cell carcinomas (TCC); however, due to reduced imaging depth of SDEOCT in cancerous lesions, staging of bladder cancers may be limited to T1 to T2a (prior to muscle invasion).

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Section: Animal Model For In Vivo Sdeoct Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vivo bladder imaging with microelectromechanical-systems-based endoscopic spectral domain optical coherence tomography

et al. 2007

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“…Recent interesting work includes removal of "complex conjugate ambiguity" 7-10 to enhance signal to noise ratio and echo-free imaging range, Doppler FDOCT to image blood flow 11,12 in real-time, ultrahigh-resolution SDOCT 13,14 for 2D and 3D retinal imaging, polarization-sensitive SDOCT 15,16 and second-harmonic-generation 17 OCT to provide more specific image contrast and thereby diagnosis of biological tissue. In addition to technological advances, clinical applications of SDOCT to various types of tissues such as the eye, 3 the esophagus 18 and the urinary bladder, 19 have been reported with drastically improved image fidelity and imaging rate. Yet, some technical issues remain to be addressed for future clinical uses despite substantial technological advances in SDOCT.…”

Section: Introductionmentioning

confidence: 99%

“…The optical layout in the distal OCT cystoscope is illustrated, which enables instantaneous visual guidance for EOCT imaging via a φ2.8 mm scope with either white light or fluorescence. 19 In the OCT cystoscope, the light exiting the SM fiber is coupled by a 0.25-pitch selfoc lens to a φ1.1 mm collimated beam and deflected by a fixed reflecting prism and a MEMS mirror. The transverse light scanning in the OCT cystoscope is facilitated by an Al-coated CMOS-MEMS planar mirror which is actuated by the applied electrical voltage.…”

Section: Introductionmentioning

confidence: 99%

Interpixel-Shifted Endoscopic Optical Coherence Tomography for in Vivo Bladder Cancer Diagnosis

Wang

Lee

Waltzer

et al. 2007

Int. J. Image Grap.

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An interpixel-shifted spectral imaging technique is applied to MEMS-based spectraldomain endoscopic optical coherence tomography (SDEOCT) to enhance signal-to-noise ratio and effective imaging depth for in vivo imaging diagnosis of biological tissue. To validate the enhancements of pixel-shifted SDEOCT, experimental comparisons are presented to image animal and human bladder architectures in vivo and to diagnose human transitional cell cancers. Preliminary study shows that interpixel shifted SDEOCT not only increases the depth of field of SDOCT but also eliminates excessive artifacts induced by spectral aliasing effect, thus improving image contrast in areas with large depths (e.g. over 1.5 mm). These results suggest that endoscopic OCT equipped with interpixelshifted spectral camera has the potential to enhance the diagnosis of biological tissue in in vivo settings that require a larger field of view in the axial direction, such as papillary bladder tumors with deep surface irregularities (e.g. asperities or invaginations).

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Increasing the imaging depth of spectral-domain OCT by using interpixel shift technique

Wang¹,

Yuan²,

Wang³

et al. 2006

Opt. Express

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A simple pixel shift technique is proposed to double the spectral sampling rate and enhance the signal to noise ratio of spectral-domain optical coherence tomography (SDOCT) in the 1.3 um wavelength range. Both theoretical analysis and experimental comparison are presented. The results show that interpixel shifted SDOCT can not only double the depth of field of SDOCT image but also eliminate the artifacts induced by aliasing effect, thus improving image contrast in areas with large depths (e.g., Delta z > or = 1.5 mm). If combined with endoscopic OCT, this technique has the potential to enhance in vivo diagnosis of biological tissues that require a larger field of view in the axial direction, such as cartilage degeneration and bladder tumors with deep asperities or invaginations.

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Cystoscopic optical coherence tomography for urinary bladder imaging in vivo

Cited by 3 publications

References 10 publications

In vivo bladder imaging with microelectromechanical-systems-based endoscopic spectral domain optical coherence tomography

In vivo bladder imaging with microelectromechanical-systems-based endoscopic spectral domain optical coherence tomography

Interpixel-Shifted Endoscopic Optical Coherence Tomography for in Vivo Bladder Cancer Diagnosis

Increasing the imaging depth of spectral-domain OCT by using interpixel shift technique

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