Cystoscopic Picture of Schistosoma Haematobium in Egyptian Children Correlated to Intensity of Infection and Morbidity

Abdelsalam, Eman M. Nagiub; Ehsan, Ahmed

doi:10.4269/ajtmh.1978.27.774

Cited by 28 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[9][10][11] A close association between the severity of the egg-induced inflammatory response or number of granulomas and eosinophiluria could therefore be expected. In this study, significant correlations between ECP levels and egg counts were found at all examinations.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8] Morbidity is associated with the intensity of the infection as estimated by S. haematobium urinary egg counts. [9][10][11][12][13] However, even at similar intensities of infection, disease sequela between individuals may vary widely. 10,14 Ultrasound examination of the urinary tract has proved to be a valuable technique in direct assessment of morbidity.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Quantitative assessment of eosinophiluria in Schistosoma haematobium infections: a new marker of infection and bladder morbidity.

Reimert¹,

Mshinda²,

Hatz³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. Eosinophiluria, as quantified by measuring eosinophil cationic protein (ECP) in urinary extracts, microhematuria, egg excretion, and ultrasound-detectable bladder pathology were recorded in Schistosoma haematobium-infected Tanzanian school children at a baseline survey and during an 18-month post-treatment followup study. Significant correlations were seen between urinary ECP levels, intensity of infection, and bladder pathology. Treatment resulted in a marked reduction in prevalence and intensity of infection, in a delayed and less marked reduction in ECP levels, and in a resolution of pathology. The overall diagnostic efficiency of the ECP test (cut-off value for the ECP Ն5 ng/ml) in relation to infection was comparable with that of egg count and microhematuria, but with a better sensitivity than a single egg count. In relation to bladder pathology, the diagnostic performance of the ECP test (cut-off value for the ECP Ն25 ng/ml) exceeded that of a single egg count. In addition, the ECP was better in discriminating between different grades of bladder pathology. The present study points to the ECP as a useful marker of both S. haematobium infection and of associated bladder morbidity reflecting the inflammatory status of the bladder wall.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Quantitative assessment of eosinophiluria in Schistosoma haematobium infections: a new marker of infection and bladder morbidity.

Reimert¹,

Mshinda²,

Hatz³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…The following classes were defined according to Abdel-Salam and Ehsan [1]: light infection below 100 ova per 10 ml, moderate infection between 100 and 350, heavy infection more than 350 ova per 10 ml urine.…”

Section: Urine Examinationmentioning

confidence: 99%

Ultrasonographical aspects of urinary schistosomiasis: Assessment of morphological lesions in the upper and lower urinary tract

Dittrich

Doehring

1986

Pediatr Radiol

View full text Add to dashboard Cite

Ultrasonographic evaluation of 213 patients with urinary schistosomiasis in different age groups was performed in an endemic area of the Democratic Republic of Congo. The results were compared with 94 age matched controls without urinary schistosomiasis. In patients the bladder showed thickening of the wall, polypoid lesions of the mucosa and bladder wall, calcifications and urinary retention. Urinary tract obstruction, predominantly unilateral, was demonstrated. The lesions increased in severity with the intensity of infection, parallel to an increase in ova excretion. Children aged between 8 and 19 years were most severely affected. Pathological lesions of the upper urinary tract were rare in patients over 25 years of age. The combination of morphological abnormalities was interpreted as being specific for urinary schistosomiasis as they did not occur in the control group. It is suggested that real time ultrasonography may be used to identify morphological lesions in urinary schistosomiasis.

show abstract

“…This has been supported by autopsy and cystoscopy studies that show a direct relationship between the intensity of S. haematobium infection and the severity of bladder wall lesions. [15][16][17][18][19] However, many children and adults with heavy infections do not show ultrasound detectable bladder wall pathology, which indicate that other factors contribute to the increased risk of gross bladder morbidity. This is supported by other studies that have failed to show a consistent correlation with bladder wall pathology with intensity of infection.…”

Section: Resultsmentioning

confidence: 99%

“…This is supported by other studies that have failed to show a consistent correlation with bladder wall pathology with intensity of infection. 2,[15][16][17][18][19][20] The duration of infection may also contribute significantly to the severity of bladder wall pathology. The cumulative frequency of urinary tract pathology increases with age, up to a point.…”

Section: Resultsmentioning

confidence: 99%

Long-term suppression of adult bladder morbidity and severe hydronephrosis following selective population chemotherapy for Schistosoma haematobium.

Subramanian¹,

Mungai²,

Ouma³

et al. 1999

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. Repeated selective population chemotherapy of school age children reduces infection and morbidity associated with Schistosoma haematobium infection. To examine the long-term effect of this treatment on susceptibility to re-infection and late disease, a cohort of Kenyans (n ϭ 194) were re-examined for infection and urinary tract morbidity 7-13 years after they underwent annual ultrasonography and treatment for an average of 5 years beginning in 1984 as children. Controls were previously untreated age-matched individuals residing in the same or adjacent villages. The overall prevalence and intensity of infection were equivalent between the 2 groups. In contrast, the prevalence of bladder wall pathology was 11-fold lower in previously treated (1.5%) versus untreated subjects (17%). Severe hydronephrosis was completely reversed. These data demonstrate that treatment significantly reduced urinary tract morbidity despite re-infection, and suggest that the important risk factors for urinary tract morbidity in adulthood are cumulative intensity and duration of infection during early adolescence.Schistosoma haematobium infection affects more than 90 million people worldwide, representing a major health problem in central and southern Africa and the eastern Mediterranean. In urinary schistosomiasis, adult female worms deposit their eggs into the lower urinary tract from the pelvic venous plexus and mesenteric veins. The pathology of urinary schistosomiasis results from host granulomatous inflammatory response to eggs trapped in the bladder, ureters, and other pelvic structures. Consequent urinary tract injury manifests as hematuria, proteinuria, bladder wall thickening, and bladder irregularities (e.g., polyps, calcifications), and a predisposition to squamous cells carcinoma of the bladder.

show abstract

Cystoscopic Picture of Schistosoma Haematobium in Egyptian Children Correlated to Intensity of Infection and Morbidity

Cited by 28 publications

References 0 publications

Quantitative assessment of eosinophiluria in Schistosoma haematobium infections: a new marker of infection and bladder morbidity.

Quantitative assessment of eosinophiluria in Schistosoma haematobium infections: a new marker of infection and bladder morbidity.

Ultrasonographical aspects of urinary schistosomiasis: Assessment of morphological lesions in the upper and lower urinary tract

Long-term suppression of adult bladder morbidity and severe hydronephrosis following selective population chemotherapy for Schistosoma haematobium.

Contact Info

Product

Resources

About