Cytochemical localization of Ca++-ATPase, H+,K+-ATPase and Na+,K+-ATPase in acid-secreting parietal cell and non-secreting parietal cell.

Ogawa, Kanta; Fujimoto, Kazushi; Ogawa, Kazuo

doi:10.1267/ahc.20.197

Cited by 20 publications

(8 citation statements)

References 40 publications

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“…Accordingly, the number of patients undergoing external-beam radiotherapy (EBRT) as curative treatment has increased (2). Despite this, the mortality rate associated with prostate cancer has continuously increased over the past few decades (3); therefore, to address this, radiotherapy combined with androgen deprivation therapy (ADT) has been evaluated for the treatment prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

Impact of the duration of hormonal therapy following radiotherapy for localized prostate cancer

et al. 2015

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Abstract. External-beam radiotherapy (EBRT) combined with androgen deprivation therapy (ADT) is known to provide improved survival outcomes compared with EBRT alone in the treatment of prostate cancer; however, the use of ADT has been reported to be associated with adverse events. Accordingly, the aim of the present study was to clarify the adequate duration of ADT when combined with EBRT to treat patients with high-risk localized prostate cancer, with consideration of survival outcomes and toxicity. Between 2001 and 2011, 173 patients with high-risk localized prostate cancer received ADT combined with EBRT, at a median dose of 69.6 Gy. Of these, 54 (31%) underwent short-term ADT (<36 months) and 119 (69%) underwent long-term ADT (≥36 months). During the median follow-up period of 54 months, the five-year progression-free survival rate of patients receiving short-term ADT (72.9%) was significantly lower than that of patients receiving long-term ADT (92.8%) (P<0.01). Furthermore, the incidence of cardiovascular toxicity at grade II or above was significantly higher amongst patients treated with short-term ADT compared with patients treated with long-term ADT (P<0.01). Thus, the present study determined that ADT for ≥36 months combined with EBRT significantly improved the progression-free survival of patients with high-risk localized prostate cancer and exhibited an acceptable toxicity profile.

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Section: Introductionmentioning

confidence: 99%

Impact of the duration of hormonal therapy following radiotherapy for localized prostate cancer

et al. 2015

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“…There have probably been no cytochemical studies in which ACLase activity and/or GCLase activity are localized on the tight junction. Moreover, we also demonstrated that ouabain-insensitive, K+-dependentp-nitrophenylphosphatase activity (K+-stimulated phosphoprotein phosphatase activity of H+, K+-ATPase system) was observed on the lateral apical membrane of the parietal cell (21). In these respects, we concluded that the tight junction of the parietal cell is the specialized junction and the cyclase activities on it may regulate the permeability on the paracellular pathway.…”

Section: Discussionmentioning

confidence: 56%

“…It was difficult to identify the activity on the tubulovesicles insomuch as the fixative of 4% FA used for ACLase brought morphological defects especially to the tubulovesicular membranes of the parietal cell. We also demonstrated that Ca++-ATPase activity and ouabain-sensitive, K+ dependent p-nitrophenylphosphatase activity were localized not only on the basal and lateral membranes, but also on some tubulovesicles in the non-secreting parietal cell (21). These findings may indicate that the tubulovesicles are not uniform in nature.…”

Section: Discussionmentioning

confidence: 77%

Cytochemical localization of adenylate cyclase and guanylate cyclase in the parietal cell of guinea pig gastric gland.

Ogawa

Fujimoto

Ogawa

1987

Acta Histochem. Cytochem

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“…Golgi membrane-associated Ca2+-ATPase is de scribed in several exocrine glands like the mouse lactating mammary gland cell [ 18], the gastric parietal cell of guinea pig [ 19] and the pyloric mucous cell of cattle [20]. In the rat ameloblast [21] ctv-fra/zs-graded activity is speculated to reflect synthesis and processing of the enzyme through the endoplasmic reticulum-Golgi route, designed to be finally integrated into the plasmalemma.…”

Section: Discussionmentioning

confidence: 99%

Calcium Adenosine Triphosphatase and Secretion of Koilin Membrane in the Gizzard of the Fowl

Salem

Kressin²,

Schnorr³

1991

Cells Tissues Organs

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The localization of calcium adenosine triphosphatase (Ca2+-ATPase) was determined histo- and ultra-cytochemicaily in the gizzard gland cells of the adult domestic fowl. Surface and chief gland cells exhibited faint and inconstant basolateral activity in contrast to basal cells, whose basolateral cell membrane constantly showed deposition on the external side. Intracellular enzyme activity was localized on the luminal aspect of Golgi membranes in all types of gland cells. Lysosomes also reacted positive for Ca2+-ATPase. Neither membranes of secretory vesicles nor cortical cytoplasm of the secretory pole exhibited enzyme activity. From these results it is speculated that calcium is not essentially involved in the secretion of the koilin membrane in terms of storage of the secretory material, transport to the secretory surface and release into the lumen. Ca2+-ATPase activity rather seems to be related to differentiation and maturation processes and to intracellular storage of Ca2+.

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Cytochemical localization of Ca++-ATPase, H+,K+-ATPase and Na+,K+-ATPase in acid-secreting parietal cell and non-secreting parietal cell.

Cited by 20 publications

References 40 publications

Impact of the duration of hormonal therapy following radiotherapy for localized prostate cancer

Impact of the duration of hormonal therapy following radiotherapy for localized prostate cancer

Cytochemical localization of adenylate cyclase and guanylate cyclase in the parietal cell of guinea pig gastric gland.

Calcium Adenosine Triphosphatase and Secretion of Koilin Membrane in the Gizzard of the Fowl

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