Cytochrome Gene Polymorphisms, Serum Estrogens, and Hot Flushes in Midlife Women

Visvanathan, Kala; Gallicchio, Lisa; Schilling, Chrissy; Babus, Janice K.; Lewis, Lynn M.; Miller, S.; Zacur, Howard A.; Flaws, Jodi A.

doi:10.1097/01.aog.0000187308.67021.98

Cited by 49 publications

(59 citation statements)

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“…In addition, a polymorphism in an estrogen metabolizing enzyme, cytochrome P450 1B1 (CYP1B1), was found to be associated with the severity, frequency, and duration of hot flashes [5]. Polymorphisms in other estrogen synthesizing and metabolizing enzymes, CYPc17α and CYP1A1, however, have not been found to be associated with hot flashes [5]. To our knowledge, studies have not examined in detail the associations between other genetic polymorphisms and hot flashes.…”

Section: Introductionmentioning

confidence: 95%

“…One band at 271 bp, one band at 166 bp, and one band at 105 bp indicated heterozygosity (+/−). Bands located at 166 bp and 105 bp indicated homozygosity for the mutant allele (−/−) [5,[25][26][27]. Detection of the CYP1A1 polymorphism was carried out using published methods and primers used were: forward 5′-CAGTGAAGAGGTGTAGCCGCT-3′, reverse 5′-TAGGAGTCTTGTCTCATGCCT-3′.…”

Section: Genotypingmentioning

confidence: 99%

“…Previous studies indicate that some sex steroid hormones, but not all, may be associated with the risk of hot flashes [4][5][6][7]. For example, studies have shown that low endogenous total (bound and free) estradiol and estrone levels are associated with hot flashes [4,5], while other studies suggest that total androgen levels may not be associated with hot flashes [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…For example, studies have shown that low endogenous total (bound and free) estradiol and estrone levels are associated with hot flashes [4,5], while other studies suggest that total androgen levels may not be associated with hot flashes [6,7]. In contrast, limited information is available on the association between free (amount unbound by sex hormone binding globulin (SHBG) and therefore thought to be biologically active) estrogen, free androgen, and progesterone levels and the risk of hot flashes.…”

Section: Introductionmentioning

confidence: 99%

“…For example, polymorphisms in estrogen receptor-α (ERα) have been associated with low response of tissues to estrogen, as well as the risk of hot flashes [8]. In addition, a polymorphism in an estrogen metabolizing enzyme, cytochrome P450 1B1 (CYP1B1), was found to be associated with the severity, frequency, and duration of hot flashes [5]. Polymorphisms in other estrogen synthesizing and metabolizing enzymes, CYPc17α and CYP1A1, however, have not been found to be associated with hot flashes [5].…”

Section: Introductionmentioning

confidence: 99%

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Genetic polymorphisms, hormone levels, and hot flashes in midlife women

et al. 2007

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Objective-Hot flashes disrupt the lives of millions of women each year. Although hot flashes are a public health concern, little is known about risk factors that predispose women to hot flashes. Thus, the objective of this study was to examine whether sex steroid hormone levels and genetic polymorphisms in hormone biosynthesis and degradation enzymes are associated with the risk of hot flashes.Methods-In a cross-sectional study design, midlife women aged 45 to 54 years (n=639) were recruited from Baltimore and its surrounding counties. Participants completed a questionnaire and donated a blood sample for steroid hormone analysis and genotyping. The associations between genetic polymorphisms and hormone levels, as well as the associations between genetic polymorphisms, hormone levels, and hot flashes were examined using statistical models.Results-A polymorphism in CYP1B1 was associated with lower dehydroepiandrosterone-sulfate (DHEA-S) and progesterone levels, while a polymorphism in CYP19 (aromatase) was associated with higher testosterone and DHEA-S levels. Lower progesterone and sex hormone binding globulin levels, lower free estradiol index, and a higher ratio of total androgens to total estrogens were associated with the experiencing of hot flashes. A polymorphism in CYP1B1 and a polymorphism in 3βHSD were both associated with hot flashes.Conclusion-Some genetic polymorphisms may be associated with altered levels of hormones in midlife women. Further, selected genetic polymorphisms and altered hormone levels may be associated with the risk of hot flashes in midlife women.

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Section: Introductionmentioning

confidence: 95%

Section: Genotypingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genetic polymorphisms, hormone levels, and hot flashes in midlife women

et al. 2007

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The association between physical activity and hot flash severity, frequency, and duration in mid‐life women

Romani

Gallicchio

Flaws

2008

American J Hum Biol

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The value of physical activity to reduce vasomotor symptoms has yet to be determined conclusively. As a result, we used a cross-sectional population-based design to examine the association between self reported physical activity level and hot flash symptoms in 45−54-year-old women. Participants (n = 603) completed a detailed survey to report physical activity level at work, home, and leisure as well as a detailed history of the frequency and severity of hot flash symptoms. Results showed that higher levels of physical activity were significantly associated with increasing odds of moderate or severe hot flashes (P for trend = 0.02). These findings suggest that there is a positive relation between physical activity and moderate or severe hot flash symptoms but no relation between physical activity and the reporting of any hot flashes, daily hot flashes, or hot flashes experienced for greater than 1 year. Am. J. Hum. Biol.Hot flashes are a common complaint of women entering the menopause transition and often result in medical intervention (Whiteman et al., 2003;Williams et al., 2007). Although hormone therapies have been shown to be effective at modulating the severity and frequency of hot flashes (Gambacciani et al., 2001), their adverse effects have placed an emphasis on alternative approaches such as behavioral or lifestyle modifications (Grady et al., 2002). Exercise and physical activity have been proposed as potential methods of vasomotor symptom reduction. However, previous studies that have examined the relation between self reported levels of exercise (Ivarsson et al., 1998;Li and Holm, 2003;Whitcomb et al., 2007) or exercise interventions (Ivarsson et al., 1998;Kemmler et al., 2004) and vasomotor symptoms have been inconclusive. Some of these studies have been limited by small sample size (Li and Holm, 2003) or a low prevalence of women experiencing vasomotor symptoms (Gambacciani et al., 2001;Ivarsson et al., 1998). Therefore, we studied the association between self reported activity level and hot flashes in a large population-based study of midlife women, 58% of whom reported vasomotor symptoms.A cross-sectional population-based study of women aged 45−54 years was conducted in Baltimore and its surrounding counties to examine the associations between demographic characteristics, health and lifestyle behaviors, and the occurrence of menopausal symptoms. The methods of this study have been described in detail elsewhere (Gallicchio et al., 2006; © 2008 Visvanathan et al., 2005) and were approved by the University of Illinois, University of Maryland School of Medicine, and Johns Hopkins University Institutional Review Boards. Briefly, women aged 45−54 years were recruited from the general population by mailing an invitation to participate to area households.Women who were interested in participating contacted the clinic and were screened by telephone. If the staff determined that they met the eligibility criteria, an appointment was scheduled for a clinic visit. Women were eligible if they were...

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Vasomotor, urogenital, psychological, and somatic symptoms in association with CYP1B1 polymorphisms in Slovak women of different menopausal status

Čerňanová

Danková

Vorobeľová

et al. 2017

American J Hum Biol

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Cytochrome Gene Polymorphisms, Serum Estrogens, and Hot Flushes in Midlife Women

Abstract: These data suggest that a CYP1B1 polymorphism may be associated with severe and persistent hot flushes, independent of E2 and estrone levels.

Cited by 49 publications

References 35 publications

Genetic polymorphisms, hormone levels, and hot flashes in midlife women

Genetic polymorphisms, hormone levels, and hot flashes in midlife women

The association between physical activity and hot flash severity, frequency, and duration in mid‐life women

Vasomotor, urogenital, psychological, and somatic symptoms in association with CYP1B1 polymorphisms in Slovak women of different menopausal status

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