Cytochrome P450 1B1: role in health and disease and effect of nutrition on its expression

Shah, Bakht Ramin; Xu, Wei; Mráz, Jan

doi:10.1039/c9ra03674a

Cited by 29 publications

(23 citation statements)

References 76 publications

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“…However, heavy smoking, which was defined by a greater number of cigarette packs smoked daily was associated with higher odds of glaucoma [60]. With this, the role of cytochrome CYP1B1 was confirmed in primary congenital glaucoma, as it influenced the development of the trabecular meshwork [61,62]; CYP1B1 is also a potential regulator in energy homeostasis that promotes hypertension as well [63].…”

Section: Systemic Hypertension and Hypotensionmentioning

confidence: 92%

Primary Open Angle Glaucoma and Vascular Risk Factors: A Review of Population Based Studies from 1990 to 2019

Grzybowski¹,

Och

Kanclerz

et al. 2020

JCM

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Glaucoma is one of the leading causes of blindness worldwide, and as the proportion of those over age 40 increases, so will the prevalence of glaucoma. The pathogenesis of primary open angle glaucoma (POAG) is unclear and multiple ocular risk factors have been proposed, including intraocular pressure, ocular perfusion pressure, ocular blood flow, myopia, central corneal thickness, and optic disc hemorrhages. The purpose of this review was to analyze the association between systemic vascular risk factors (including hypertension, diabetes, age, and migraine) and POAG, based on major epidemiological studies. Reports presenting the association between POAG and systemic vascular risk factors included a total of over 50,000 patients. Several epidemiological studies confirmed the importance of vascular risk factors, particularly hypertension and blood pressure dipping, in the pathogenesis and progression of glaucomatous optic neuropathy. We found that diabetes mellitus is associated with elevated intraocular pressure, but has no clear association with POAG. No significant correlation between migraine and POAG was found, however, the definition of migraine varied between studies.

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Section: Systemic Hypertension and Hypotensionmentioning

confidence: 92%

Primary Open Angle Glaucoma and Vascular Risk Factors: A Review of Population Based Studies from 1990 to 2019

Grzybowski¹,

Och

Kanclerz

et al. 2020

JCM

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“…In the Human Gene Mutation Database (http://www.hgmd.cf.ac.uk; accessed on 6 May 2021), 240 variants of the CYP1B1 gene are listed. The association of their function with the pathogenesis of diseases in humans has been recently intensively studied [21]. Molecular structures of pathogenic CYP1B1 mutant variants are analyzed in relation to their impaired function with the use of the most advanced bioinformatics tools.…”

Section: The Role Of Cyp1b1 In the Pathogenesis Of Diseasesmentioning

confidence: 99%

“…Glaucoma is a group of eye diseases leading to the irreversible loss of vision. In the development of glaucoma, the CYP1B1 gene is involved: primary congenital glaucoma (PCG) constitutes 55% of inherited pediatric onset of the disease and is caused predominantly by mutations in the CYP1B1 gene [21].…”

Section: Cyp1b1 Contribution In Pathogenesis Of Eye Diseasesmentioning

confidence: 99%

New Perspectives of CYP1B1 Inhibitors in the Light of Molecular Studies

Mikstacka

Dutkiewicz

2021

Processes

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Human cytochrome P450 1B1 (CYP1B1) is an extrahepatic heme-containing monooxygenase. CYP1B1 contributes to the oxidative metabolism of xenobiotics, drugs, and endogenous substrates like melatonin, fatty acids, steroid hormones, and retinoids, which are involved in diverse critical cellular functions. CYP1B1 plays an important role in the pathogenesis of cardiovascular diseases, hormone-related cancers and is responsible for anti-cancer drug resistance. Inhibition of CYP1B1 activity is considered as an approach in cancer chemoprevention and cancer chemotherapy. CYP1B1 can activate anti-cancer prodrugs in tumor cells which display overexpression of CYP1B1 in comparison to normal cells. CYP1B1 involvement in carcinogenesis and cancer progression encourages investigation of CYP1B1 interactions with its ligands: substrates and inhibitors. Computational methods, with a simulation of molecular dynamics (MD), allow the observation of molecular interactions at the binding site of CYP1B1, which are essential in relation to the enzyme’s functions.

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“…Есть «Офтальмология. Восточная Европа», 2021, том 11, № 3 Обзоры данные, что его количественные и качественные изменения становятся причиной энергетического дисбаланса в трабекулярной сети и способствуют развитию ПОУГ [38]. Кроме того, образование аномального цитохрома нарушает процессы детоксикации, метаболизма биологически активных веществ, ксенобиотиков.…”

Section: влияние полиморфных вариантов генов-кандидатов на развитие п...unclassified

Распространенность И Эпидемиология Первичной Открытоугольной Глаукомы

Isaev¹,

Сердюк²,

Устименко³

2021

Офтальмология. Восточная Европа

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Глаукома рассматривается как гетерогенная группа заболеваний со специфическим изменением биомеханики передней и задней камер глаза, результатом чего является увеличение продукции и уменьшение оттока водянистой влаги. Прогрессирующая дегенерация ганглиозных клеток сетчатки, микроглии, астроцитов, клеток Мюллера приводит к хроническому повреждению, истончению нейроретинального слоя и сужению поля зрения. Предметом данного исследования стала первичная по происхождению глаукома с открытым углом (ПОУГ). Именно ПОУГ, по данным многих исследований Американской оптометрической ассоциации, является наиболее распространенным видом глаукомы (72-96%), особенностью которой выступает беcсимптомность развития с постепенным снижением периферического зрения. Причиной такого патологического состояния являются повреждение зрительного нерва, неэффективность дренажной системы глаза с накоплением жидкости и повышением ВГД. Проблема изучения развития и прогрессирования ПОУГ из года в год становится все более актуальной. Анализ эпидемиологических исследований за последние полвека показал, что заболеваемость глаукомой демонстрирует стремительный рост. Данная статья представляет собой обзор литературы с точки зрения выделения ряда геновкандидатов. Значительный научный интерес представляет полиморфизм гена NOS3 через его влияние на формирование эндотелиальной дисфункции. Определение связи полиморфизмов rs1799983 и rs2070744 с развитием и прогрессированием ПОУГ. Поиск литературы выполнялся по таким базам научной литературы, как Web of Science, Google Scholar, PubMed, Scopus и другие. Генетическая детерминированность возникновения и прогрессирования ПОУГ позволяет выделить ряд генов-кандидатов. Значительный научный интерес представляет полиморфизм гена NOS3 из-за его влияния на формирование эндотелиальной дисфункции. Определение связи полиморфизмов rs1799983 и rs2070744 с развитием и прогрессированием ПОУГ, клиническими проявлениями заболевания позволит усовершенствовать ее раннюю диагностику и профилактику осложнений. Glaucoma is considered as a heterogeneous group of diseases with a specific change in biomechanics of the anterior and posterior chambers of the eye, resulting in a production increase and a decrease in aqueous humor outflow. Progressive degeneration of retinal ganglion cells, microglia, astrocytes, Mueller cells, leads to chronic damage, thinning of the neuroretinal layer and narrowing of visual field. The subject of this study is a primary in origin open-angle glaucoma (POAG). According to many studies by the American Optometric Association, POAG is the most common type of glaucoma (72-96%), characterized by asymptomatic development with a gradual decrease in peripheral vision. The reason for this pathological condition is damage of optic nerve, inefficiency of eye drainage system with fluid accumulation and increased intraocular pressure. The problem of POAG development and progression study becomes more and more relevant each year. In terms of epidemiological studies for the past 50 years, the incidence of glaucoma morbidity shows a rapid progressive increase. Review of the literature in terms of identifying a number of candidate genes. The polymorphism of the NOS3 gene through its influence on the formation of endothelial dysfunction is of considerable scientific interest. Determination of the relationship of the rs1799983 and rs2070744 polymorphisms with the development and progression of POAG. This article is а literature rewiev was performed in following database of scientific literature: Web of Science, Google Scholar, PubMed, Scopus and others. The genetic determinism of the occurrence and progression of POAG makes it possible to identify a number of candidate genes. The polymorphism of the NOS3 gene is of considerable scientific interest due to its influence on the formation of endothelial dysfunction. Determination of the relationship between the rs1799983 and rs2070744 polymorphisms with the development and progression of POAG, clinical manifestations of the disease will improve its early diagnosis and prevention of complications.

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Cytochrome P450 1B1: role in health and disease and effect of nutrition on its expression

Abstract: This review summarizes the available literature stating CYP1B1 to provide the readers with a comprehensive understanding of its role in different diseases, as well as the importance of nutrition in their control in terms of the influence of different nutrients on its expression.

Cited by 29 publications

References 76 publications

Primary Open Angle Glaucoma and Vascular Risk Factors: A Review of Population Based Studies from 1990 to 2019

Primary Open Angle Glaucoma and Vascular Risk Factors: A Review of Population Based Studies from 1990 to 2019

New Perspectives of CYP1B1 Inhibitors in the Light of Molecular Studies

Распространенность И Эпидемиология Первичной Открытоугольной Глаукомы

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