Cytochrome P450 variations in different ethnic populations

McGraw, Joseph; Waller, Donald P.

doi:10.1517/17425255.2012.657626

Cited by 244 publications

(175 citation statements)

References 81 publications

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“…SNPs have been identified that may result in variant CYP450 enzyme expression and/or activity (McGraw and Waller, 2012). In this study, we chose representative alleles of CYP1A2, among which CYP1A2*1F is reported to be associated with increased activity, while the CYP1A2*1C, CYP1A2*2, CYP1A2*7, and CYP1A2*11 variants are associated with decreased activity of the CYP1A2 gene (Zhou et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

CYP1A2 polymorphism in Chinese patients with acute liver injury induced by Polygonum multiflorum

Ma¹,

Zhang²,

Jia³

2014

Genet. Mol. Res.

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ABSTRACT. The objective of this study was to evaluate the genotype and allelic frequencies of CYP1A2 in Chinese patients with acute liver injury induced by Polygonum multiflorum. We examined the clinical mechanism of acute liver injury induced by P. multiflorum. According to the diagnostic criteria for drug-induced liver injury (DILI), 43 cases of P. multiflorum-induced liver injury admitted to the First Affiliated Hospital, Zhejiang University were identified between January 2008 and December 2012. An additional 43 control subjects were also chosen. Several alleles, including *1C, *1F, *2, *7, *9, and *11 of CYP1A2 were amplified from genomic DNA and sequenced. We used the chi-square test to determine whether CYP1A2 allele polymorphisms are associated with acute liver injury induced by P. multiflorum. The frequency of the CYP1A2 *1C allele was 46.5% in P. multiflorum-induced DILI patients, which was significantly different from the frequency of 27.9% observed in healthy subjects. The frequency of the CYP1A2*1F allele was 63.9% in P. multiflorum-induced DILI patients, compared to 57.0% in healthy controls; the difference was not significant. The allelic frequencies of CYP1A2*2, CYP1A2*7, CYP1A2*9, and CYP1A2*11 were too low to be detected. The frequency of the CYP1A2*1C mutation in Chinese patients with P. multiflorum-induced acute liver injury differed from that in healthy Chinese people, indicating that CYP1A2*1C is probably related to metabolism of P. multiflorum, which is followed by acute liver injury.

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Section: Discussionmentioning

confidence: 99%

CYP1A2 polymorphism in Chinese patients with acute liver injury induced by Polygonum multiflorum

Ma¹,

Zhang²,

Jia³

2014

Genet. Mol. Res.

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“…When compared to the Caucasian population, both Asian and African populations have lower CYP1A2 activities (39). Fourteen percent of Japanese people and 5% of Chinese people were found to be PMs (17,27).…”

Section: Cyp1a2mentioning

confidence: 99%

“…The distribution of common variant alleles of CYP2C19 has been found to vary among different ethnic groups. The PM phenotype is more prevalent in the Asian population and less in Caucasian and African populations (please see below) (17). The PM phenotype of CYP2C19 is inherited as an autosomal recessive trait (28,29) (Table 2).…”

Section: Cyp2c19mentioning

confidence: 99%

Genetics of antipsychotic drug outcome and implications for the clinician: into the limelight

Changasi

Shams

Pouget

et al. 2014

Translational Developmental Psychiatry

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Background and purpose: Antipsychotics (APs) are the primary method of treatment for schizophrenia and other psychotic disorders. Unfortunately, lengthy trial-and-error approaches are typically required to find the optimal medication and dosage due to a large interindividual variability with outcome to AP treatment. The literature has shown abundant evidence for a genetic component in individuals' responses to APs. Pharmacogenetic studies analyze specific genetic markers and their association with symptom improvement and occurrence of side effects with APs. This research aims to optimize AP drug treatment by usage of predictive testing and to personalize medicine. Recent findings: This review will highlight the most consistent findings in pharmacogenetics of APs and will update the reader on the clinical implications. This will include how genetic variants modulate AP drug levels, side effects, and therapeutic symptom improvement (i.e. response) to AP treatment. Summary: Several promising findings were obtained implicating gene variants of the dopamine receptor genes in addition to gene variants of serotonin receptors for response and common side effects. Notably, effect sizes appear to be particularly high in the genetics of side effects compared to response. One example is antipsychotic-induced weight gain where the leptin, HTR2C and in particular the melanocortin-4-receptor (MC4R) genes have been implicated in weight gain in children and adolescents. Consistent findings were also obtained for genes implicated in tardive dyskinesia and agranulocytosis. However, the most clinically relevant findings pertain to genes involved in drug metabolism such as the CYP2D6 and CYP2C19 genes which have been included in the first genetic test kits such as the Amplichip †

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“…Furthermore, the frequencies of CYP2C9*3 allele were similar between the Vietnamese-Koreans and Africans (3.2% and 0.5-2.3%) but Caucasians exhibited high proportion of this allele (3.3-17%). This suggests that Vietnamese-Koreans have less clinical significance caused by CYP2C9 genotype than Caucasian population [32]. Second, in the distribution of CYP2C19, the Vietnamese-Koreans have low frequency of *17 (2.0%) compared to Caucasians and African-Americans (~20% and 17-18%).…”

Section: Transl Clin Pharmacolmentioning

confidence: 96%

Genetic polymorphisms of CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 in Vietnamese-Koreans

Lim

Cha

Jung

et al. 2014

Transl Clin Pharmacol

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Cytochrome P450 variations in different ethnic populations

Cited by 244 publications

References 81 publications

CYP1A2 polymorphism in Chinese patients with acute liver injury induced by Polygonum multiflorum

CYP1A2 polymorphism in Chinese patients with acute liver injury induced by Polygonum multiflorum

Genetics of antipsychotic drug outcome and implications for the clinician: into the limelight

Genetic polymorphisms of CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 in Vietnamese-Koreans

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