2012
DOI: 10.1074/jbc.m111.316364
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Cytochromes P450 CYP94C1 and CYP94B3 Catalyze Two Successive Oxidation Steps of Plant Hormone Jasmonoyl-isoleucine for Catabolic Turnover

Abstract: Background: Oxidized derivatives of the plant hormone jasmonoyl-isoleucine accumulate in wounded Arabidopsis leaves. Results: Cytochromes P450 CYP94C1 and CYP94B3 cooperate to catalyze the formation of 12OH-JA-Ile and 12COOH-JA-Ile. Conclusion: CYP94C1 and CYP94B3 define a major route for JA-Ile catabolism. Significance: Elucidation of CYP94-mediated JA-Ile oxidation opens new avenues for understanding jasmonate metabolism and signaling.

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Cited by 238 publications
(279 citation statements)
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“…JA levels showed a stronger increase after wounding, pointing at a more efficient flux through this pathway in the continuous presence of the fungus. Elevated JA-Ile levels were observed in mockand V. longisporum-infected coi1-t plants, which is consistent with previously published data that COI1 is required for the induction of JA-Ile-metabolizing enzymes (Koo et al, 2011;Heitz et al, 2012). These elevated levels of JA-Ile are unlikely to interfere with fungal growth, since coi1-16 shoots grafted on wild-type roots are as susceptible as shoots of wild-type plants (Fig.…”
Section: Coi1 In the Roots Influences The Disease Phenotype Of The Shootsupporting
confidence: 78%
“…JA levels showed a stronger increase after wounding, pointing at a more efficient flux through this pathway in the continuous presence of the fungus. Elevated JA-Ile levels were observed in mockand V. longisporum-infected coi1-t plants, which is consistent with previously published data that COI1 is required for the induction of JA-Ile-metabolizing enzymes (Koo et al, 2011;Heitz et al, 2012). These elevated levels of JA-Ile are unlikely to interfere with fungal growth, since coi1-16 shoots grafted on wild-type roots are as susceptible as shoots of wild-type plants (Fig.…”
Section: Coi1 In the Roots Influences The Disease Phenotype Of The Shootsupporting
confidence: 78%
“…One of the mechanisms for limiting the JA response is inactivation of bioactive JA-Ile by the cytochrome P450 CYP94B3 (Kitaoka et al, 2011;Koo et al, 2011;Heitz et al, 2012;Koo and Howe, 2012). cyp94B3 loss-offunction mutants exhibit increased production of JA-Ile and enhanced expression of JA-responsive genes after wounding, indicating a crucial role for JA-Ile catabolism in attenuation of JA responses.…”
Section: Introductionmentioning
confidence: 99%
“…CYP94B3 and CYP94C1 oxidize JA-Ile at the C12 position, leading to sequential accumulation of the oxidized derivatives 12OH-JAIle and 12COOH-JA-Ile (20 -22). This oxidative metabolism accounts largely for the transient nature of JA-Ile accumulation after wounding and, similarly to other plant hormones (23), corresponds to the attenuation of the hormonal signal, as plants with perturbed JA-Ile oxidizing activity have an altered JA response (20,22).…”
mentioning
confidence: 99%