Cytocompatibility studies of titania-doped calcium borosilicate bioactive glasses in-vitro

Samudrala, Raj Kumar; P, Abdul Azeem; Penugurti, Vasudevarao; Manavathi, Bramanandam

doi:10.1016/j.msec.2017.03.245

Cited by 44 publications

(8 citation statements)

References 43 publications

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“…Release of ions will greatly alter the localized pH values which have significant effects on the cell viability. Although the addition of TiO2 in the glass, decreased the kinetics of CaP layer formation, but it could be beneficial in terms of pH control which hence could enhance cell viability (Samudrala et al, 2017). Aside from the high dissolution rate for silicate bioactive glasses, another major concern is the change in mechanical properties when these materials are immersed within a biological environment, which is indicated by any changes in hardness due to reactions with a physiological environment (Kashyap et al, 2011).…”

Section: Resultsmentioning

confidence: 99%

“…Studies conducted on osteoblast adhesion to titanium samples with different surface characteristics showed that osteoblast cells are capable of adhering onto all the samples in both flattened and elongated morphology (Feng et al, 2004). Samudrala et al studied the biological behavior of Titania doped calcium borosilicate bioactive glass compositions, where they reported that titanium doped glasses exhibited lower solubility of glass and an increase in cell viability (Samudrala et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, with current knowledge of bioactive glass compositions, the hypothesis is that substitution of TiO2 within the glass system will increase the network stability of the glass and decrease the dissolution rates (Samudrala et al, 2017). Controlled dissolution rates of glass will stabilize localized pH and hence improves the cell viability, and attachment (Babu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Analysis of structure, bioactivity and hardness of titanium incorporated bioactive glass

2019

Biomater Tissue Eng Bull

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A series of bioactive glass composition were prepared, and the effects of TiO2 addition on the structure, bioactivity and hardness of the glasses were analyzed. This study consisted of glass characterization, simulated body fluid (SBF) trials, and hardness testing. Three glasses were formulated, where a SiO2-CaO-Na2O-P2O5 bioactive glass was used as control, with the addition of 5 and 10 wt.% TiO2 at the expense of CaO. X-ray diffraction patterns confirmed that an amorphous microstructure was obtained for all three glasses. Differential thermal analysis indicated an increase in the glass transition temperature of the glass series from 660°C to 721°C with the incorporation of TiO2. Hot stage microscopy results exhibited higher sintering and softening temperatures for TiO2 containing glasses. Each glass was then incubated in SBF for 1, 10, and 30 days. Scanning electron microscopy images confirmed that the calcium phosphate particulates were precipitated on control glass after 10 days, however, for TiO2 containing glasses, the deposition layer was only observed after 30 days. The hardness of SBF incubated samples were tested, where TiO2 containing glasses showed significantly higher hardness values at each incubation period, with 0.72 GPa for control and 1.71 GPa for the TiO2 containing glass, after 30 days of incubation.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Analysis of structure, bioactivity and hardness of titanium incorporated bioactive glass

2019

Biomater Tissue Eng Bull

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“…In this context, they examined the bioactivity of various concentrations of TiO 2 doped glasses with the help of simulated body fluid (SBF). Cytocompatibility, cell proliferation, and protein expression studies revealed the potential candidature of TiO 2 doped glasses on osteoblast cell lines (MG-63) [199]. Bellucci et al tested a set of novel materials for bone tissue regeneration in vivo in an animal model.…”

Section: The Latest Studiesmentioning

confidence: 99%

Biyoaktif Camlar

Karasu

YANAR

Koçak

et al. 2017

El-Cezeri Fen Ve Mühendislik Dergisi

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Bioactive glasses were discovered in 1969 and provided for the first time an alternative to nearly inert implant materials. They formed a rapid, strong, and stable bond with host tissues. This article examines the frontiers of research crossed to achieve clinical use of bioactive glasses and glass-ceramics. In the 1980s, it was discovered that bioactive glasses could be used in particulate form to stimulate osteogenesis, which thereby led to the concept of regeneration of tissues. Later, it was found that the dissolution ions from the glasses behaved like growth factors, providing signals to the cells. Hereby, the frontiers of knowledge crossed during four eras of development of bioactive glasses led from concept of bioactivity to widespread clinical and commercial use, with emphasis on the first composition, 45S5 Bioglases® were mentioned. The four eras are (a) discovery, (b) clinical application, (c) tissue regeneration, and (d) innovation. Questions still to be answered for the fourth era are included to stimulate innovation in the field and exploration of new frontiers that can be the basis for a general theory of bioactive stimulation of regeneration of tissues and application to numerous clinical needs.

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“…As titanium has antitumour properties and favours cell response [22,23], the present work aims to evaluate the effect of different contents of TiO 2 , SiO 2 and CaO on sintering, microstructure, mechanical properties and biological response of silicon nitride ceramics for use as prosthetic components.…”

Section: Introductionmentioning

confidence: 99%

Silicon nitride with titania, calcia and silica additives for orthopaedic applications

Guedes-Silva

Rodas

Carvalho

et al. 2020

PAC

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Titanium, silicon and calcium ions have demonstrated positive effects in bone healing. Therefore, this paper investigates the densification, mechanical properties and in vitro biological behaviour of TiO 2 , together with SiO 2 and CaO, on silicon nitride ceramics to be used in clinical applications. The results revealed that the sintered samples reached high values of relative density and fracture toughness, non-cytotoxicity as well as good ability to promote cell proliferation and form a layer of carbonated hydroxyapatite on their surfaces, after immersion in simulated body fluid. The sample with the highest amount of TiO 2 reached the highest value of relative density and the best results of cell proliferation and fracture toughness, indicating the great potential to be explored by in vivo experiments for later application as intervertebral devices.

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Cytocompatibility studies of titania-doped calcium borosilicate bioactive glasses in-vitro

Cited by 44 publications

References 43 publications

Analysis of structure, bioactivity and hardness of titanium incorporated bioactive glass

Analysis of structure, bioactivity and hardness of titanium incorporated bioactive glass

Biyoaktif Camlar

Silicon nitride with titania, calcia and silica additives for orthopaedic applications

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