Cytogenetic analysis in nine leukaemic cats

Grindem, Carol B.; Buoen, L. C.

doi:10.1016/0021-9975(89)90073-x

Cited by 23 publications

(10 citation statements)

References 14 publications

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“…Chromosomal abnormalities are also seen in benign tumors and in non-tumorous cells exhibiting abnormal growth as well (Wurster-Hill et al, 1988). In spite of this, not all tumors analyzed showed chromosomal aberrations (Grindem and Buoen, 1989;Wolman, 1983).…”

Section: Discussionmentioning

confidence: 91%

“…They are found in most malignancies that are retrovirus-positive as well as retrovirus-negative (Grindem and Buoen, 1989), with the exception of some tumors caused by retrovirus with one genes; i.e., genes encoding for transformation (Duesberg, 1987 b). Furthermore, chromosomal abnormalities are diagnostic of neoplastic disease (Wolman, 1983).…”

Section: Discussionmentioning

confidence: 99%

“…Chromosomal abnormalities are found both in tumors infected by retroviruses without one genes as well as in uninfected tumors (Grindem and Buoen, 1989;Duesberg, 1987 b;Duesberg, 1987 c;Rowley, 1984;Trent, 1984;Wolman, 1983;Levan, 1956). Thus, otherwise indistinguishable tumors may be retrovirus-positive or retrovirus-negative.…”

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confidence: 99%

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Chromosome abnormalities and oncogenesis in cat leukemias

Gulino

1992

Cancer Genetics and Cytogenetics

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Chromosome abnormalities and oncogenesis in cat leukemias

Gulino

1992

Cancer Genetics and Cytogenetics

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“…Chromosomal instability and the resulting aneuploidy, like other types of genomic instability, is considered to be important for multistep tumorigenesis through the accumulation of alterations responsible for malignant phenotype [15,22,30]. Although a number of chromosomal abnormalities have been revealed in cat tumors [9,10,42], the centrosome amplification has yet to be explored.…”

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confidence: 99%

Centrosome Amplification and Chromosomal Instability in Feline Lymphoma Cell Lines

Miki

Okuda

Oikawa

et al. 2004

The Journal of Veterinary Medical Science

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ABSTRACT. To evaluate the presence of centrosome amplification and the resulting chromosomal instability in cat tumors, a newly established feline lymphoma cell line and four already established feline lymphoma cell lines were examined using immunohistochemical analysis of centrosomes. The number of chromosomes were subsequently counted by metaphase spread. Moreover, to explore whether mutational inactivation of the p53 gene or inactivation of the P53 protein caused by mdm2 gene overexpression, occurred in the feline lymphoma cell lines, mutational analysis of the feline p53 gene was carried out. The expression of feline mdm2 mRNA was evaluated by reverse transcriptase-polymerase chain reaction (RT-PCR). Centrosome amplification and chromosomal instability was observed in three out of the five feline lymphoma cell lines. Of these three feline lymphoma cell lines, one had aberrations in the P53 amino-acid sequence, whereas the others had none. There was no significant difference in the expression of mdm2 mRNA between peripheral blood mononuclear cells (PBMC) obtained from a normal cat and that of the five feline lymphoma cell lines. These findings indicate th at centrosome amplification also occurs in cat tumors and is strongly correlated with chromosomal instability, suggesting that the immunostaining of centrosomes could be an alternative method for the examination of the chromosomal instability. Furthermore, this study s uggests the presence of unknown mechanism that leads to the centrosome amplification in feline lymphomas.

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“…Leukemias and malignant lym phomas are frequently found in the domestic cat, and various chromosome aberrations have been reported in cases of these diseases both with and without feline leukemia virus (FeLV) infection (Goh et al, 1981;Grindem and Buoen, 1989;Gulino, 1992). Chromosome aberrations are also seen in feline mam mary tumors (Mayr et al, 1995;Mayr et al, 1996a) and histio cytomas (Mayr et al, 1996b).…”

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confidence: 99%

A proposed nomenclature of the domestic cat karyotype

Cho

Youn

Watari

et al. 1997

Cytogenet Genome Res

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High-resolution G- and Q-band patterns of cat (Felis catus) prometaphase chromosomes with more than 450 numbered bands are presented. This number represents approximately twice the number of bands per haploid set exhibited by feline chromosomes at mid-metaphase. A diagrammatic representation of G-banded cat chromosomes has already been described (O’Brien and Nash, 1982); however, precise numbering of bands and landmarks, as in the human karyotype and in the karyotypes of other domestic and laboratory animals, has not yet been available for the domestic cat karyotype, except for the RBG-banded ideograms constructed by Shibasaki et al. (1987) and Rønne and Storm (1995). In this report, we propose a numbering system for the G-banded ideogram reported previously (O’Brien and Nash, 1982) and an extended ideogram at the high-resolution level (473 numbered bands) as a contribution to the future standardization of the feline karyotype.

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Cytogenetic analysis in nine leukaemic cats

Cited by 23 publications

References 14 publications

Chromosome abnormalities and oncogenesis in cat leukemias

Chromosome abnormalities and oncogenesis in cat leukemias

Centrosome Amplification and Chromosomal Instability in Feline Lymphoma Cell Lines

A proposed nomenclature of the domestic cat karyotype

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