Cytogenetic analysis of gingival epithelial cells, as related to smoking habits and occurrence of periodontal disease

Increased micronuclei and nuclear abnormalities in buccal mucosa and oxidative damage in saliva from patients with chronic and aggressive periodontal diseases

“…However, D'Agostini et al . evaluate the induction of MN and binucleated cells in the gingival epithelium, as related to smoking habits and the occurrence of periodontal disease . Their results did not show any significant association between cytogenetic damage in gingival cells, smoking habits and gingivitis or periodontal disease.…”

Assessment of Cytogenetic Damage to Exfoliated Gingival Cells in Patients with Chronic Generalized Periodontitis

“…Gingival mucosal cells are not keratinized epithelial cells, characterized by a high turnover, which has previously been used for evaluating molecular and biochemical alterations in gingivitis and periodontitis ( 19 , 20 ). Periodontal disease is an inflammatory process involving a set of changes that directly affect tissues that hold the teeth.…”

“…D’Agostini et al . report that there was no significant elevation of micronucleated and binucleated cells in gingival epithelium related to periodontal disease (gingivitis and periodontitis) ( 20 ). The authors observed a higher frequency of binucleated cells in periodontitis positive subjects (1.55±0.25) compared to controls (1.31±0.15) but it was not statistically significant.…”

Comparación de las manifestaciones periodontales en una muestra de consumidores de chimú y cigarrillo en Villavicencio, Colombia

“…Pero, en este estudio, los fumadores presentaron mayor prevalencia de la enfermedad periodontal que los consumidores de chimú. En relación con esto, D'Agostinia et al consideran que el tabaco, en sus diferentes presentaciones, tiene relación con la progresión de la enfermedad periodontal [7], ya que su patogénesis está vinculada con una compleja interacción entre el medio ambiente microbiano, la genética y otros factores del huésped, lo que convierte el tabaco en el factor de riesgo ambiental más importante [7].…”