Cytogenetic and genetic effects of subchronic treatments with organophosphorus insecticides

Degraeve, N.; Chollet, Marie-Christine; Moutschen, J.

doi:10.1007/bf00316356

Cited by 25 publications

(5 citation statements)

References 3 publications

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“…The percentage of preimplantation losses was not significantly increased and the frequency of post-implantation fetal mortality was lower than the control level. by ingestion of water containing small amounts of the organophosphate (8 ppm, corresponding to the highest value allowed in Belgium for pesticide residues in fruits and vegetables) five days a week for seven consecutive weeks 69 . Again, they did not observe a significant increase in chromosomal breaks or gaps in the same cell types from the previous work, nor in the dominant lethal mutation assay.…”

Section: Malathionmentioning

confidence: 99%

Carcinogenicidade e mutagenicidade do malathion e seus dois análogos: uma revisão sistemática

Bastos

Gurgel

et al. 2020

Ciênc. saúde coletiva

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Resumo O agrotóxico malathion vem sendo amplamente utilizado no mundo em programas de controle de arboviroses e em 2015 foi classificado pela Agência Internacional para Pesquisas em Câncer (IARC) como provável agente carcinogênico para seres humanos. Este trabalho objetivou a sistematização das evidências dos efeitos carcinogênicos e mutagênicos associados à exposição do malathion e seus análogos, malaoxon e isomalathion. A busca foi realizada nas bases de dados TOXLINE, PUBMED e SCOPUS por artigos originais publicados de 1983 a 2015. Do total de 273 artigos elegíveis, foram selecionados 73. Os resultados dos estudos in vitro e in vivo evidenciaram danos genéticos e cromossômicos provocados pelo malathion; os estudos epidemiológicos evidenciaram associações significativamente positivas para cânceres de tireóide, de mama, e ovariano em mulheres na menopausa. Estas evidências do efeito carcinogênico do malathion devem ser considerados diante de sua utilização em programas de controle de arboviroses.

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Section: Malathionmentioning

confidence: 99%

Carcinogenicidade e mutagenicidade do malathion e seus dois análogos: uma revisão sistemática

Bastos

Gurgel

et al. 2020

Ciênc. saúde coletiva

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“…Genotoxicity data on malathion are mixed. The mutagenicity of malathion has been supported in some studies [Pluth et al, 1996;USEPA, 2000;Giri et al, 2002a;Reus et al, 2008], but not others [Degraeve et al, 1984, Windham et al 1998, Osaba et al 1999. The US EPA Gene-Tox Program (http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?GENETOX) has determined that malathion does not induce gene mutations in the Salmonella, E. coli or Drosophila sexlinked recessive lethal assays.…”

Section: Introductionmentioning

confidence: 96%

Malathion and fenvalerate induce micronuclei in mouse bone marrow cells

Giri

Sharma

2011

Environ. Mol. Mutagen.

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Health effects of pesticides are a major public health concern. In this study, the genotoxic effects of two commonly-used pesticides, malathion, and fenvalerate, were investigated in mice in vivo. Induction of micronuclei in bone marrow cells was used as the test parameter following exposure to 2.5, 5 or 10 mg/kg malathion by intraperitoneal (i.p.) or per oral (p.o.) exposure. Exposure by both routes was found to cause a significant increase in micronucleated polychromatic erythrocytes (PCEs) in a dose-dependent manner (r = 0.9769; P < 0.05). The highest dose (10 mg/kg) induced significant (P < 0.05) cytotoxicity. In contrast, fenvalerate caused an increase in micronucleated PCEs only at higher doses (10 and 20 mg/kg) via i.p. injection, and was not associated with cytotoxicity. A significant dose-response correlation was not observed in the dose ranges tested for fenvalerate (r = 0.8704; P > 0.05). The results suggest that technical grade malathion is a genotoxic agent. In contrast, technical grade fenvalerate appears to be a potent genotoxic agent, but this observation should be confirmed with further investigation(s).

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“…Nevertheless, a lot of these compounds and the byproducts of their breakdown are DNA alkylating agents (Bedford and Robinson 1972). Therefore, it is essential to look for any prospective genetic harm caused by minimal exposure with organophosphorus pesticides (Degraeve et al 1984).…”

Section: Introductionmentioning

confidence: 99%

Phenthoate toxicity evaluation in root meristem of Pisum sativum L.

Siddiqui

2023

Caryologia

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Phenthoate is an organothiophosphate insecticide. Effect of phenthoate on the cytogenetic alterations in root tip cells of Pisum sativum L., a multiuse crop was investigated in this study. Pisum sativum L. seeds were exposed to different concentrations of phenthoate (0.1, 0.2, 0.3, 0.4, and 0.5%) and were germinated at 24°C for 72 hours and cytogenetic alterations were assessed. Analysis of mitotic index revealed that phenthoate has cytotoxic attributes, and cell proliferation kinetics frequencies showed alterations in the kinetics of the mitotic process. Phenthoate treatment of 0.1% to 0.5% resulted in an increase in the metaphases, and a reduction in prophases, anaphases, and telophases ratio, dose dependently. The findings of the study reveal that, phenthoate reduced the percentage of seed germination, mitotic index, radicle length and increased chromosomal abnormalities dose dependently. Root tip cells of Pisum sativum L. seeds treated with phenthoate showed an increased occurrence of single and double bridges, fragments, stickiness, laggard, and vagrants.

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Cytogenetic and genetic effects of subchronic treatments with organophosphorus insecticides

Cited by 25 publications

References 3 publications

Carcinogenicidade e mutagenicidade do malathion e seus dois análogos: uma revisão sistemática

Carcinogenicidade e mutagenicidade do malathion e seus dois análogos: uma revisão sistemática

Malathion and fenvalerate induce micronuclei in mouse bone marrow cells

Phenthoate toxicity evaluation in root meristem of Pisum sativum L.

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