Cytogenetic biomonitoring of an Italian population exposed to pesticides: chromosome aberration and sister-chromatid exchange analysis in peripheral blood lymphocytes

Cytogenetic Monitoring in a Population Occupationally Exposed to Pesticides in Ecuador

“…Another study (Kourakis et al 1992) reported 2.66% CAs in the exposed group and also found higher frequencies in those who work exclusively in green houses compared with those who work in the open air. Similar studies show 6% and 11% CAs in exposed individuals (De Ferrari et al 1991;Rupa and Reddi 1991).…”

“…Cytogenetic damage related to pesticide exposure has been reported in various populations. Some investigators have reported significant differences in the percentage of CAs in exposed individuals (range, 2.66-10.30%) compared with control (range, 0.53-5.52%) (Balaji and Sasikala 1993;Brega et al 1998;De Ferrari et al 1991;Joksic et al 1997; Kourakis et al 1992;Rupa and Reddi 1991;Yoder et al 1973); others have not (de Cassia Stocco et al 1982;Hoyos et al 1996;Steenland et al 1986).…”

Instabilidade cromossômica induzida por agroquímicos em trabalhadores rurais na região de Passo Fundo, Rio Grande do Sul, Brasil

“…Assim, aumentos significativos na incidência de aberrações cromossômicas e/ou no intercâmbio de cromátides irmãs, foram constatadas por De Ferrari et al (1991), em floricultores; por Kourakis et al (1992), em trabalhadores em casas de vegetação e por Carbonell et al (1995) e Bréga et al (1998), em trabalhadores de zonas rurais. Em relação aos micronú-cleos, sua freqüência acha-se significativamente aumentada nos floricultores italianos estudados por Bolognesi et al (1993), embora Scarpato et al (1996) relatem achados negativos em estudo semelhante.…”

Pesticides: Genotoxic Risk of Occupational Exposure

“…Several studies on the chromosomal effect of pesticides have been made using CA; the positive results obtained showed a correlation with the exposure time (Dulout et al, 1985;Paldy et al, 1987;Rupa et al, 1989a;Carbonell et al, 1993;Joksić et al, 1997;Kaioumova & Khabutdinova, 1998;Cuenca & Ramírez, 2004;Zeljezic et al, 2009). Other positive results did not find correlation between the exposure time and the CA induction (Rita et al, 1987;Rupa et al, 1988, 1989b, 1991a, El-Ghazali et al, 1990Kourakis et al, 1992;Scarpato et al, 1996;Amr, 1999;Au, 1999;Antonucci & de Syllos Colus, 2000;Lander et al, 2000;Paz-yMiño et al, 2002;Sailaja et al, 2006); meanwhile others authors although also found positive frequency of CA but did not determined this correlation (Nehéz et al, 1988;Jabloniká et al, 1989;De Ferrari et al, 1991;Carbonell et al, 1995;Mohammad et al, 1995;Kourakis et al, 1996;Lander et al, 2000;Garaj-Vrhovac & Zeljezic, 2001, 2002Ascarrunz et al, 2006;Ergene et al, 2007;Mañas et al, 2009). As well negative results have been obtained (Mustonen et al, 1986;Steenland et al, 1986;Hoyos et al, 1996;D'Arce & de Syllos Colus, 2000;…”

“…The studies of cytogenetic biomonitoring in human populations exposed to pesticides show different results because diverse biomarkers have been widely utilized in heterogeneous populations (Paldy et al, 1987;Rupa et al, 1989a,b;De Ferrari et al, 1991;Carbonell et al, 1993;Bolognesi et al, 2002Bolognesi et al, , 2004. In studies on the exposure to pesticides the genotoxic effects of such biomarkers should be considered; the research should also take into account the damage resulting from the exposure, the robustness of the studies, the similarity of the control groups and the protocols used to determine the genotoxicity (Bull et al, 2006).…”