Instabilidade cromossômica induzida por agroquímicos em trabalhadores rurais na região de Passo Fundo, Rio Grande do Sul, Brasil

Pacheco, Adil de Oliveira; Hackel, Christine

doi:10.1590/s0102-311x2002000600022

Cited by 11 publications

(4 citation statements)

References 43 publications

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“…Similar data to the findings in this study, are verified in the work of Pacheco and Hackel (2002), who found a significant increase of cells with NM in the exposed group.…”

Section: Resultssupporting

confidence: 92%

Cellular Changes in Buccal Mucosa from Farmers Exposed to Glyphosate / Alterações Celulares na Mucosa Bucal de Agricultores Expostos ao Glifosato

Kupske¹,

Baroni²,

Zamin³

2021

BJDV

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This study evaluated the sociodemographic characteristics and behavior of the oral mucosa epithelium exposured to the herbicide glyphosate of family farmers in Cerro Largo, RS, Brazil. 120 individuals were selected for social data collection through interviews. According to the results, most of the interviewees uses glyphosate between 5-10 years, being exposed between 30 minutes to one hour each application and applying the herbicide 1-2 times a year. After the interview, we selected the subjects to the Micronucleus (MN) test. For this test, oral smears were performed in three distinct regions (cheek, mouth floor and tongue edges) of 10 test subjects (exposed to glyphosate, non-smoker and non-alcoholic) and 10 control subjects. Results showed that glyphosate exposure increased the frequency of MN in the test group (p = 0.0002), as well as the frequency of other cellular alterations, such as brokenegg (p = 0.001), binucleation (p = 0.0001) and karyolysis (p = 0.0004). Based on these findings, the extent use of glyphosate may be causing damage to the oral mucosa epithelium and this might respond adaptively through cellular modifications.

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“…Similar data to the findings in this study, are verified in the work of Pacheco and Hackel (2002), who found a significant increase of cells with NM in the exposed group.…”

Section: Resultssupporting

confidence: 92%

Cellular Changes in Buccal Mucosa from Farmers Exposed to Glyphosate / Alterações Celulares na Mucosa Bucal de Agricultores Expostos ao Glifosato

Kupske¹,

Baroni²,

Zamin³

2021

BJDV

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“…This is dangerous because several studies have demonstrated the genotoxic and carcinogenic potential of different pesticides (CONTRERAS et al, 1998;PACHECO;HACKEL, 2002;BORTOLI;AZEVEDO;SILVA, 2009).…”

Section: Chromosomal Aberration Testmentioning

confidence: 99%

Cytotoxicity and mutagenicity of cola and grape flavored soft drinks in bone marrow cells of rodents

et al. 2013

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Due to the large consumption of soft drinks in Brazil and worldwide in recent years and considering that some of the components present in their composition pose potential risks to human health, the aim of this study was to evaluate the cytotoxic and mutagenic potential of specific cola and grape-flavored soft drink brands. Bone marrow cells of Wistar rats were initially treated by gavage with one single dose of Cola or Grape soft drink, which was next offered ad libitum (instead of water) for 24 hours. A negative control treatment was performed by administering one single dose of water and a positive control administering cyclophosphamide intraperitoneally. Statistical analysis showed that the Cola and Grape soft drinks studied were not cytotoxic. However, the Cola soft drink proved mutagenic in this experiment treatment time. Therefore, this study serves as a warning about the consumption of Cola-flavored soft drink and for the need for further subchronic and chronic studies on soft drinks in order to evaluate the long term mutagenic and cytotoxic effects of these substances.

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“…The indiscriminate use of pesticides goes beyond acute intoxication, causing chronic health problems. Agricultural workers in Rio Grande do Sul suffer from increased DNA damage and chromosome instability (e.g., micronuclei, nuclear buds) due to pesticide exposure [70][71][72][73]. Pesticides are associated with neurodegenerative diseases, including dementia [74], Parkinson's [75][76][77], and Alzheimer's diseases [74,78], as well as cancer [52,79], reproductive and fetal development problems, and psychiatric disorders [52].…”

Section: Consequences Of Pesticides On Human Healthmentioning

confidence: 99%

Pesticide Pollution in the Brazilian Pampa: Detrimental Impacts on Ecosystems and Human Health in a Neglected Biome

Ziliotto,

Kulmann-Leal,

Roitman

et al. 2023

Pollutants

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The Brazilian Pampa biome covers half of Rio Grande do Sul state, in the extreme south of Brazil, creating an ecotone zone with the Atlantic Forest and bordering Pampa’s territory belonging to Uruguay and Argentina. Pampa is a non-forest biome mainly composed of grasslands and mosaics of grassland-forest vegetation. This biome shows significant animal and plant diversity, contributing to the maintenance of important ecosystem services, including CO2 capture, pollination, and water cycle regulation. However, forestry plantations, inappropriate cattle ranching, mining activities, unplanned urbanization, and the cultivation of monocultures (soy, rice, tobacco, and other cash crops) significantly threaten the conservation of the Pampa biome. A major problem observed in the Pampa, due to the great connection of this biome with agricultural areas, is pesticide pollution, which significantly affects the health of humans and animals that occupy the region. A robust body of evidence indicates that aquatic and terrestrial ecosystems in the Brazilian Pampa are extensively contaminated with pesticides, as indicated by studies involving animal biomarkers and pesticide analyses performed on water and soil samples. Human studies also suggest that pesticides affect different body systems, facilitating the onset of various chronic diseases. Brazil’s conservation actions and policies have a special focus on forest ecosystems, neglecting non-forest biomes and thus aggravating the problems related to Pampa’s conservation. In this article, we discuss some problems caused by pesticide pollution in the Brazilian Pampa, drawing attention to the need for intensification of policies focused on the promotion of human and environmental health. Finally, we suggest the bioecological bioeconomy as an alternative for Rio Grande do Sul to progress its economic development but with less dependency on detrimental activities to the Pampa biome.

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Instabilidade cromossômica induzida por agroquímicos em trabalhadores rurais na região de Passo Fundo, Rio Grande do Sul, Brasil

Abstract: A major share of the grain farming (wheat and soybeans) in the State of Rio Grande do Sul is in the Passo Fundo area. For crop pest control, large amounts of agrochemicals (fungicides, insecticides, and herbicides)

Cited by 11 publications

References 43 publications

Cellular Changes in Buccal Mucosa from Farmers Exposed to Glyphosate / Alterações Celulares na Mucosa Bucal de Agricultores Expostos ao Glifosato

Cellular Changes in Buccal Mucosa from Farmers Exposed to Glyphosate / Alterações Celulares na Mucosa Bucal de Agricultores Expostos ao Glifosato

Cytotoxicity and mutagenicity of cola and grape flavored soft drinks in bone marrow cells of rodents

Pesticide Pollution in the Brazilian Pampa: Detrimental Impacts on Ecosystems and Human Health in a Neglected Biome

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