Cytogenetic changes in the Bhopal population exposed to methyl isocyanate (MIC) in 1984: Then and 30 years later

Ganguly, Bani Bandana; Mandal, Shouvik

doi:10.1016/j.mrgentox.2017.10.004

Cited by 10 publications

(3 citation statements)

References 49 publications

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“…Due to the high volatility of the isocyanates, the trace unreacted isocyanates can enter the body through the respiratory tract, skin, etc., resulting in a variety of acute and chronic injuries, such as bronchial asthma, pneumonia, pulmonary edema, chronic obstructive pulmonary disease, and hepatomegaly . Animal experiments have shown carcinogenic and mutagenic effects in addition to symptoms such as stimulation, inflammation, allergies, and hepatic injury . Therefore, non‐isocyanate PUs have received widespread attention due to the absence of isocyanates toxicity that is hazardous to operators and the environment in the manufacturing and application processes …”

Section: Introductionmentioning

confidence: 99%

Fluorescent poly(hydroxyurethane): Biocompatibility evaluation and selective detection ofFe(III)

Liu

Zhang

et al. 2018

J of Applied Polymer Sci

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Polyurethane (PU) is widely used in biomedical applications owing to its excellent physical and chemical properties. As an isocyanate‐free PU material, fluorescent poly(hydroxyurethane) (FPHU) is synthesized from the addition of the cyclic carbonates with amines rather than the toxic isocyanate with diols, which reduces the possible injury to the human due to trace amounts of the isocyanate residues. Herein, we report the biocompatibility of a FPHU that can be synthesized from carbon dioxide, bisepoxides, and diamine in tandem. Of unique, FPHU exhibits a strong blue fluorescence and is selectively sensitive to Fe3+ with a detection limit of 4.56 μM. The overall results of the methylthiazolyldiphenyl‐tetrazolium, cytokine release, and hemolysis assays for FPHU indicates that FPHU has much lower cytotoxicity and immunotoxicity compared with the traditional isocyanate PU, as well as a good blood compatibility with less than 5% hemolysis rate. Therefore, FPHU presents as a kind of safer PU and can be prospectively applied in medical materials.

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Section: Introductionmentioning

confidence: 99%

Fluorescent poly(hydroxyurethane): Biocompatibility evaluation and selective detection ofFe(III)

Liu

Zhang

et al. 2018

J of Applied Polymer Sci

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“…Thus, to conclude, though the cytogenetic changes are reported similar to earlier studies, it cannot be solely attributed to the exposure to toxic gas as many confounding factors may also contribute genetic damage but such studies are signi cant for assessing the risk (Ganguly and Mandal, 2017;Ganguly et al, 2019). Further, because of the complex interactions between environment, disease susceptibility and genetic susceptibility, the exploration of epigenetic mechanisms to meet challenges of CKD through novel ideas of molecular mechanisms is warranted.…”

Section: Discussionmentioning

confidence: 55%

“…However, low birth weight, genetic/developmental/growth disorders and respiratory ailments were thrust areas of research. Few cytogenetic studies were also undertaken to assess genetic damage in gas exposed population (Goswami et al, 1984;Goswami 1986;Goswami et al, 1990;Ghosh et al, 1990;Malla et al, 2011, Senthilkumar et al, 2013Ganguly and Mandal, 2017, Ganguly, 2019. However, no studies are available on cytogenetic damage of toxic gas exposed population having CKD.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cytogenetic alterations of toxic gas exposed population of Bhopal having chronic kidney disease

Samarth

Tiwari²,

Modi³

et al. 2021

Preprint

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The industrial disaster of Bhopal in 1984 resulted into widespread morbidity and mortality in the vicinity of the industry and required long term surveillance for chronic health effects in those affected by the leakage of gas. Although few cytogenetic studies were undertaken to assess genetic damage in survivors of the disaster, no studies are available on cytogenetic damage of toxic gas exposed population having chronic kidney disease (CKD).Thus, the present study aimed to evaluate cytogenetic alterations in chronic kidney disease patients who wereexposed to leaked gas and to compare it with those who were not exposed to the leaked gas. The cytogenetic alterations were evaluated through chromosomal aberration analysis and micronuclei assay. The study included 608 study participants divided into four groups on the basis of history of exposure to the leaked gas and presence or absence of CKD. The results of the study showed no statistically significant difference in cytogenetic damagebetween gas exposed and non-exposed patients of CKD. However, significantly higher cytogenetic damage was observed among gas exposed participants having CKD as compared to gas exposed participants free from CKD.Thus, to conclude though the cytogenetic alterations were observed in exposed group it cannot be solely attributed to the gas exposure and the role of other confounders must also be studied.

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Lesson from the MIC Accident May Guide for Alternative Approaches to Minimize Environmental Pollution

Ganguly,

Kadam

2024

Recent Advances in Environmental Science From the Euro-Mediterranean and Surrounding Regions (4th Edition)

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Cytogenetic changes in the Bhopal population exposed to methyl isocyanate (MIC) in 1984: Then and 30 years later

Cited by 10 publications

References 49 publications

Fluorescent poly(hydroxyurethane): Biocompatibility evaluation and selective detection ofFe(III)

Fluorescent poly(hydroxyurethane): Biocompatibility evaluation and selective detection ofFe(III)

Evaluation of cytogenetic alterations of toxic gas exposed population of Bhopal having chronic kidney disease

Lesson from the MIC Accident May Guide for Alternative Approaches to Minimize Environmental Pollution

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