Cytogenetic Characterization of Childhood Hepatoblastoma

Ma, S.K.; Cheung, Annie N.Y.; Choy, Carolyn; Chan, Godfrey C. F.; Ha, Sy; Ching, L. M.; Wan, T. S. K.; Li, Chan

doi:10.1016/s0165-4608(99)00203-4

Cited by 23 publications

(18 citation statements)

References 29 publications

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“…Distribution of chromosome gains and losses in our series and in previously reported cases of 98 abnormal karyotypes. Columns above the x axis represent total number of instances of chromosome gain; columns below the x axis, total number of instances of chromosome loss (Petkovic et al, 1985;Mascarello et al, 1990;Fletcher et al, 1991;Rodriguez et al, 1991;Soukup et al, 1991;Anneren et al, 1992;Bardi et al, 1992;Dressler et al, 1993;Tonk et al, 1994;Swarts et al, 1996;Bove et al, 1996;Parada et al, 1997;Schneider et al, 1997;Sainati et al, 1998;Balogh et al, 1998;Parada et al, 2000;Ma et al, 2000;Yeh et al, 2002;Ali et al, 2002;Gunawan et al, 2002;Sainati et al, 2002). (Tonk et al, 1994;Genes Chromosomes Cancer 11:199-202 Previously reported (Schneider et al, 1997;Genes Chromosomes Cancer 19:291-294 Previously reported (Tonk et al, 1994;Genes Chromosomes Cancer 11:199-202).…”

Section: Discussionmentioning

confidence: 99%

“…All previous reports were on small series or single cases (Petkovic et al, 1985;Mascarello et al, 1990;Fletcher et al, 1991;Rodriguez et al, 1991;Soukup et al, 1991;Anneren et al, 1992;Bardi et al, 1992;Dressler et al, 1993;Tonk et al, 1994;Bove et al, 1996;Swarts et al, 1996;Parada et al, 1997Parada et al, , 2000Schneider et al, 1997;Balogh et al, 1998;Sainati et al, 1998Sainati et al, , 2002Ma et al, 2000;Yeh et al, 2000;Ali et al, 2002;Gunawan et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Trisomy 20, trisomy of all or part of chromosome 2, and/or trisomy of all or part of chromosome 8 were recognized early on as the most common cytogenetic abnormalities in hepatoblastoma, having been reported in 34 (81%) of the 42 published cases. In addition, recurring unbalanced translocations involving chromosomes 1 and 4 were reported in eight tumors (Schneider et al, 1997;Sainati et al, 1998;Ma et al, 2000;Parada et al, 2000). No data exist, however, for determining how common these abnormalities are in hepatoblastomas overall.…”

Section: Introductionmentioning

confidence: 99%

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Cytogenetic evaluation of a large series of hepatoblastomas: Numerical abnormalities with recurring aberrations involving 1q12–q21

Tomlinson

Douglass

Pollock

et al. 2005

Genes Chromosomes & Cancer

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Hepatoblastoma is a malignant embryonal liver tumor that occurs almost exclusively in infants and very young children. Previous cytogenetic studies of hepatoblastoma have investigated small series or individual cases. This report is on the cytogenetics of a large series of 111 hepatoblastoma specimens, with cytogenetic results consecutively karyotyped over a 12-year period. Abnormal karyotypes were observed in 55 cases (approximately 50% of the total). Numerical aberrations were observed in 41 cases (36% of the total), particularly trisomies of chromosomes 2, 8, and 20. Chromosome losses were less common than chromosome gains. Structural abnormalities were observed in 43 cases (39% of the total). Unbalanced translocations resulting in trisomy 1q and involving breakpoints at 1q12-21 were the most common structural abnormality, observed in 20 tumors (18% of total cases); the corresponding translocated chromosome was highly varied. The previously reported t(1;4) was observed in seven cases. Most tumors with translocations involving 1q12-21 also displayed numerical chromosome aberrations, the most common of which were chromosomal trisomies, whereas tumors with other structural rearrangements had fewer numerical abnormalities.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cytogenetic evaluation of a large series of hepatoblastomas: Numerical abnormalities with recurring aberrations involving 1q12–q21

Tomlinson

Douglass

Pollock

et al. 2005

Genes Chromosomes & Cancer

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“…Schneider et al reported a recurring chromosomal aberration, der(4)t(1q;4q), in four hepatoblastoma patients [33], and two subsequent cases have been reported [30,34]. Four of the six cases have the same abnormality, der(4)t(1;4)(q12;q34).…”

Section: Abutting the Middle Hepatic Vein (Black Arrows) B) T1-weighmentioning

confidence: 99%

Childhood Cancers: Hepatoblastoma

2000

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Hepatoblastoma is the most common primary liver tumor in children, accounting for just over 1% of pediatric cancers. The etiology is unknown, but it has been associated with Beckwith-Weidemann syndrome, familial adenomatosis polypi, and low birth weight. The primary treatment is surgical resection, however, chemotherapy plays an important role by increasing the number of tumors that are resectable. The prognosis for patients with resectable tumors is fairly good, however, the outcome for those with nonresectable or recurrent disease is poor. Texas-Houston Medical School, 1515 Holcombe Blvd., Houston, Texas 77030, USA. Telephone: 713-745-0157; Fax 713-792-0608; e-mail: cherzog@ mdanderson.org Received June 21, 2000; accepted for publication September 6, 2000. ©AlphaMed Press 1083-7159/2000 INTRODUCTIONHepatoblastoma is the most common malignant tumor of the liver in children. Surgery remains the primary means of curative therapy, but the role of chemotherapy in both the adjuvant and neoadjuvant setting has become increasingly important over the past three decades. New insight has also been gained into the molecular biology of hepatoblastoma.

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“…These studies have found a spectrum of changes, with predominance of alterations associated with gains of chromosomes 1q, 2/2q, 7, 8, 20, and 21 as well as loss of 4q [7,8,[20][21][22][23][24][25][26][27]. Recurring 1q12-21 aberrations [7,21], chromosome 1 and 4 translocations [7,27], and X chromosome aberrations [8] have also been reported.…”

Section: Discussionmentioning

confidence: 99%