Cytogenetic effects in workers occupationally exposed to tobacco dust

Umadevi, B.; Swarna, M.; Padmavathi, P.; Jyothi, A.; Reddy, P. P.

doi:10.1016/s1383-5718(02)00291-7

Cited by 17 publications

(11 citation statements)

References 17 publications

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“…Exposure to tobacco dust is known to affect the respiratory tract in humans. [10] This study was designed to investigate the beedi tobacco dust exposure and its effect on pulmonary function status. The present study shows an association between pulmonary function impairments and exposure to beedi tobacco dust.…”

Section: Discussionmentioning

confidence: 99%

A study to assess the respiratory impairments among the male beedi workers in unorganized sectors

Chattopadhyay

Kundu

Mahata

et al. 2006

Indian J Occup Environ Med

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Aims: The dust of tobacco enters the respiratory system of beedi workers through inhalation during beedi-making and causes respiratory impairments. The aim of the present study is to evaluate the pulmonary functional status of male beedi workers and to detect the pulmonary function impairments among these workers. Materials and Methods: A standard questionnaire was followed to note the symptoms like cough, breathlessness, morning cough and chest tightness. The tendu leaves contain fungal spores in different phases of its processing, particularly when they were kept in bundles in moist condition before wrapping the beedi. In the present study, pulmonary function status assessment was done by spirometric method using Spirovit-SP-10 and Wright's peak flow meter. Out of the total subjects studied (n=107), 56 were control subjects and 51 were workers exposed to beedi. Statistical Analysis: Paired t-test was done to determine the significant difference between beedi workers and control subjects. Result: A few workers reported symptoms of cough, breathlessness, morning cough and chest tightness. The respiratory symptoms were found higher in exposed beedi workers compared to control subjects. A trend of decrement of lung volumes with the increment of age and duration of work exposure was observed. The pulmonary function abnormalities found among the male beedi workers were obstructive, restrictive and 'combined restrictive and obstructive' type. Conclusion:The respirtory impairments among the beedi workers might be due to their exposure to the work environment.

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Section: Discussionmentioning

confidence: 99%

A study to assess the respiratory impairments among the male beedi workers in unorganized sectors

Chattopadhyay

Kundu

Mahata

et al. 2006

Indian J Occup Environ Med

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“…[71] SCE frequency was also elevated in the lymphocytes of habit-free tobacco processors. [57] A significant increase in the frequency of chromosomal aberrations was observed in PBL from tobacco processors with or without smoking habits [72] with the frequency of chromosomal aberrations increasing with the number of years of exposure.…”

Section: Micronucleus Formationmentioning

confidence: 98%

Chemistry and toxicology of smokeless tobacco

Ra¹

2012

Indian J Cancer

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In most parts of the world, tobacco is used for smoking, whereas, in India, tobacco is used for smoking as well as in diverse smokeless forms. Absorption of toxic and carcinogenic chemicals in tobacco and other ingredients added to various products are causally associated with several non-communicable diseases including cancer, especially oral cancer, which is the leading cancer among men and the third most common cancer among women in India. This article highlights the toxicity, mutagenecity and carcinogenic effects of hazardous chemicals present in smokeless tobacco products. This endeavor was based on the extensive review of literature from various sources. The SLT products have influence on cellular metabolism, ability to cause DNA damage, and cancer in experimental animals. It is, therefore, essential to consider the collective role of chemical constituents of SLT products in the causation of adverse effect on human health.

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“…It is one of the established risk factors for oral cancer. The carcinogenetic potential of tobacco is well known[12] However, not all tobacco consumers suffer ultimate consequences. This might be due to the genetic polymorphism or different DNA repair capability of individuals towards the causative factor.…”

Section: Introductionmentioning

confidence: 99%

“…It shows an elevated occurrence of chromosome aberrations, micronuclei in buccal epithelial cells, higher percentage of cells showing DNA damage (studied by comet assay) as compared to a normal individual of the same age and socio economic conditions. His urinary thioether excretion was also examined.Cases of genotoxicity due to tobacco chewing have been reported taking buccal micronuclei or chromosome aberrations into consideration[1214] but the reports of such cases including the composite effects of the chewing habit on buccal micronuclei, chromosome aberrations, DNA damage by comet assay and urinary thioether excretion levels have not been come across.…”

Section: Introductionmentioning

confidence: 99%

Genotoxic effects of tobacco chewing

Khanna¹,

Gautam²,

Mukherjee³

2012

Toxicol Int

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Tobacco chewing is a widespread habit which leads to DNA damage. We are reporting a case of a tobacco chewer in which chromosomal aberrations, DNA breakage, buccal micronuclei and urinary thioether excretion level were studied. The study was carried out on a 28 year old male subject who is polio affected since his childhood. He has been chewing tobacco since the last 17 yrs @ 4 g, 08 times per day. The medical report of the subject indicates no abnormalities except post-polio paralysis in both lower limbs. He has no family history of any genetic disorder. He is not occupationally exposed to tobacco. The findings of the present investigation indicate increased incidence of chromosomal aberration % and micronuclei in buccal epithelial cells than the control values obtained from a subject of similar age and socioeconomic condition but not addicted to tobacco chewing. However, the urinary thioether values of the subject were lower than control values indicating a depression of the detoxification pathway.

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Cytogenetic effects in workers occupationally exposed to tobacco dust

Cited by 17 publications

References 17 publications

A study to assess the respiratory impairments among the male beedi workers in unorganized sectors

A study to assess the respiratory impairments among the male beedi workers in unorganized sectors

Chemistry and toxicology of smokeless tobacco

Genotoxic effects of tobacco chewing

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