Cytogenetic effects of hexavalent chromium in Bulgarian chromium platers

Benova, D.; Hadjidekova, Valeria; Hristova, Rositsa; Nikolova, Teodora; Boulanova, Minka; Georgieva, I.; Grigorova, M.; Popov, Todor A.; Panev, Teodor; Georgieva, R; Natarajan, A.T.; Darroudi, F.; Nilsson, Robert

doi:10.1016/s1383-5718(01)00320-5

Cited by 77 publications

(34 citation statements)

References 26 publications

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“…The cytogenetic damage in exposed humans has been reported by many authors and most of the published reports are restricted to occupational exposures to ionizing radiation (Maluf 2004), heavy metals (Benova et al 2002;Clemens and Landolph 2003;Wise et al 2003), and PCBs (Kalina et al 1991;Joksić and Marković 1992).…”

Section: Discussionmentioning

confidence: 99%

“…Heavy metals are cytotoxic, genotoxic and carcinogenic. Benova et al (2002) studied the cytogenetic and molecular effects of Cr(VI) on peripheral lymphocytes and exfoliated buccal cells employing a chromosomal aberration assay, sister-chromatid exchanges and micronucleus test. The data obtained from exposed works showed a significant increase in the number of cells with MN in lymphocytes as well as in the buccal cells.…”

Section: Monitoring Of Lymphocyte Micronuclei Amongmentioning

confidence: 99%

See 1 more Smart Citation

Monitoring of Lymphocyte Micronuclei among Newborns from Kragujevac in Central Serbia before and after Environmental Contamination

Milošević-Djordjević

Grujičić

Arsenijevic

et al. 2005

Tohoku J. Exp. Med.

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Section: Discussionmentioning

confidence: 99%

Section: Monitoring Of Lymphocyte Micronuclei Amongmentioning

confidence: 99%

Monitoring of Lymphocyte Micronuclei among Newborns from Kragujevac in Central Serbia before and after Environmental Contamination

Milošević-Djordjević

Grujičić

Arsenijevic

et al. 2005

Tohoku J. Exp. Med.

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“…Cr and Cr compounds have been tested for genotoxicity in a variety of short-term tests using different end-points [28,29,16]. Moreover, there are reports on positive genotoxic effects in populations exposed to Cr [9,30,25,3,11]. Workers occupationally exposed to Cr are considered to be at an elevated risk for developing cancer [27,13].…”

Section: Introductionmentioning

confidence: 99%

Micronucleus Test in Exfoliated Buccal Cells from Chromium Exposed Tannery Workers

Sudha¹,

Prathyumnan²,

Joseph³

et al. 2011

IJBBB

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Abstract-Our aim was to investigate the adverse effects of occupational exposure to trivalent chromium in tannery workers and unexposed persons. Trivalent chromium used in tanning industry is an environmental contaminant that acts as a carcinogen towards humans and animals. The carcinogenic potential of metals is a major issue in defining human health risk from exposure. In the present investigation, 84 tannery workers and 52 control subjects with similar mean ages, smoking prevalences and alcohol consumption were enrolled for DNA damage analysis in buccal cells by Micronucleus assay (MN). Workers showed a significant increase in micronucleated cells when compared to controls with respect to their smoking habits, alcohol consumption, age and years of exposure. The current study suggests that chronic occupational exposure to Chromium during tanning could lead to increased levels of DNA damage. The results of the present investigation are in agreement with those obtained with the same Cr (III) compounds in mutagenicity assays in bacteria and carcinogenicity tests in rodents. A re-evaluation of the mechanisms of chromium carcinogenisis is proposed.

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“…These data have been strongly supported by studies confirming that the target of ROS is DNA with possible strand breaks or mutation in addition to the alteration in transcription activities [34] . However, in another study, no significant difference was observed between exposed and controls workers exposed to chromium with regard to the frequency of peripheral lymphocytes with chromosome aberrations [35] . Nowadays, DNA-protein cross-links are considered a promising biomarker signaling an exposure of body tissues to biologically active forms of chromium [36] .…”

Section: Discussionmentioning

confidence: 85%

The Role of Cd40 Ligand in Early Detection of Chromium-Induced Immunotoxic Effects Among Exposed Workers

Rashed

2007

Egypt. J. Occup. Med.

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Objective: the immunological effect of chromium exposure among workers in tanning industry was assessed by studying the incidence of structural chromosomal aberrations in lymphocytes. Early monitoring of immunotoxicity and possibility of carcinogenecity using the CD40 ligand member of the tumor necrosis superfamily of trans-membrane proteins was evaluated.Methods: levels of chromium in blood (S-Cr) and urine (U-Cr) were measured using the graphite furnace atomic absorption spectrophotometer. The CD40 Ligand (CD40L) was determined using ELISA. Whole blood was treated and chosen metaphases were recorded and scored for morphological aberrations and rearrangements.Results: the study was carried out on 30 workers exposed to chromium in chrome-tanning for 17.13 ± 8.09 years, and a matched group of 28 administrative workers. The mean serum chromium levels (S-Cr) were 4.35 ± 1.46 and 1.89 ± 1.31 µg/dl among exposed and control groups, respectively, and the difference was statistically significant, P<0.00±. The CD40L assessment revealed decreased levels among the exposed population, difference was statistically non-significant. The genotoxic changes in the form of chromosomal and chromatid gaps and breaks as well as dicen-237

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Cytogenetic effects of hexavalent chromium in Bulgarian chromium platers

Cited by 77 publications

References 26 publications

Monitoring of Lymphocyte Micronuclei among Newborns from Kragujevac in Central Serbia before and after Environmental Contamination

Monitoring of Lymphocyte Micronuclei among Newborns from Kragujevac in Central Serbia before and after Environmental Contamination

Micronucleus Test in Exfoliated Buccal Cells from Chromium Exposed Tannery Workers

The Role of Cd40 Ligand in Early Detection of Chromium-Induced Immunotoxic Effects Among Exposed Workers

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