Cytogenetic effects of inhaled ozone

Tice, Raymond R.; Bender, Michael A.; Ivett, J. L.; Drew, Robert T.

doi:10.1016/0165-1218(78)90022-8

Cited by 29 publications

(3 citation statements)

References 27 publications

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“…These values compare with in vivo exposures reported to produce low levels of chromosome damage in rodents (0.43 ppm for 5 hr ca. 0.5) [Tice et al, 1978) and in humans (0.5 ppm for 10 hrs) [Merz et al, 19751. Although the reports on the in vivo cytogenetic effects of ozone are contradictory, they do demonstrate that, as with the Salmonella data, the dose-time exposure regimen for achieving exposures to ozone that induce detectable genotoxicity may be more important than the total dose (concentration and time) given.…”

Section: ( I 1)mentioning

confidence: 99%

Ozone is mutagenic in salmonella

Dillon¹,

Combes²,

McConville³

et al. 1992

Environ and Mol Mutagen

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Ozone is a highly reactive gas that has been tested for genotoxicity in a number of systems. Induced genetic damage resulting from ozone treatment may not be readily observed because of the high toxicity of the chemical and difficulties in generating and administering controlled concentrations. The mutagenicity of ozone was investigated in Salmonella typhimurium using a plate test protocol designed for reactive vapours and gases. Ozone, at two to three consecutive doses, induced weak, albeit statistically significant, mutagenic responses in tester strain TA102 with and without Aroclor-induced rat liver s9 (lowest effective mean concentration of 0.019 ppm; 35 min total exposure). However, dose-related responses were not always obtained. No mutagenicity was detected in strains TA98, TA100, or TA1535, with or without S9. In strain TA104, ozone induced a weak response only at a single dose with S9; this response was not reproducible. Mutagenicity was dependent on the ozone flow rate and total exposure time, with variations in the optimum dase-time regimen leading to toxicity or complete inactivity. The data show that ozone is a very weak bacterial mutagen and only when tested under narrowly prescribed, subtoxic dosing conditions. 0 1992 Wiley-Liss, Inc.

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Section: ( I 1)mentioning

confidence: 99%

Ozone is mutagenic in salmonella

Dillon¹,

Combes²,

McConville³

et al. 1992

Environ and Mol Mutagen

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“…Chromosome aberrations have been reported in the peripheral lymphocytes of Chinese hamsters after an exposure of the animals to 0.24 or 0.33 ppm O 3 for 5 h; no decrease in DNA damage could be detected 2 weeks after exposure. 15 In contrast, Tice et al 20 who studied Chinese hamsters at different concentrations (up to 2.0 ppm for 6 h) did not find any increase in chromosome aberrations.…”

Section: Discussionmentioning

confidence: 93%

In vivo ozone exposure does not increase DNA single-strand breaks in human peripheral lymphocytes

et al. 2013

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In this randomized parallel study, we examined whether an acute ozone (O3) exposure leads to increased DNA strand breaks in human lymphocytes. The groups were exposed to 0.21 ppm O3 or filtered air for two hours. 30min and 4.5 h after exposure, DNA damage was determined in isolated lymphocytes using the Fast Micromethod. There was no detectable effect after O3 exposure. We conclude that an acute O3 exposure at the tested concentration does not lead to persistent DNA damage.

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“…While ozone is an established inhalation toxicant producing a variety of effects, including toxicity of the lung and other organs (9)(10)(11)(12), there have been relatively few studies on the toxicity of ozone or its reaction products when administered via aqueous solution. Short-term, in vitro bioassays on ozonated drinking water samples and organics isolated from the same have produced mixed results.…”

Section: Discussionmentioning

confidence: 99%

Subchronic toxicity study of ozonated and ozonated/chlorinated humic acids in Sprague-Dawley rats: a model system for drinking water disinfection

Daniel¹,

Robinson²,

Ringhand³

et al. 1991

Environ. Sci. Technol.

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Male and female Sprague-Dawley rats were administered drinking water containing humic acids either nondisinfected or following ozonation (03) or ozonation/ chlorination (03/Cl2) for 90 consecutive days. Test animals drank either of two concentrations of humic acids, 0.25 and 1.0 g/L total organic carbon (TOC), while controls received phosphate-buffered, distilled water. No consistent significant treatment-related effects were observed in body weight gain, organ weights, food or water consumption, or hematological and clinical chemistry parameters. No target organs were identified from the histopathological examination of the tissues. The most significant observation, an increase in liver to body weight ratio for the male animals in the 1.0 g/L 03/Cl2 humic acid group, was not observed in any other group, nor was it corroborated via any biochemical measurements or histopathological analysis. Kidney lesions, primarily chronic progressive nephropathy, were a common observation in both controls and treated groups with no apparent relationship to either humic acid concentration or the disinfection process.

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Cytogenetic effects of inhaled ozone

Cited by 29 publications

References 27 publications

Ozone is mutagenic in salmonella

Ozone is mutagenic in salmonella

In vivo ozone exposure does not increase DNA single-strand breaks in human peripheral lymphocytes

Subchronic toxicity study of ozonated and ozonated/chlorinated humic acids in Sprague-Dawley rats: a model system for drinking water disinfection

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