Cytogenetic effects of X-rays in the guinea pig female germ cells. II. The maturing oocyte

Jacquet, P.; Saint-Georges, L. de; Buset, Jasmine; Baatout, Sarah; Vankerkom, Jean; Baugnet‐Mahieu, L.

doi:10.1016/s1383-5718(97)00068-5

Cited by 12 publications

(11 citation statements)

References 16 publications

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“…Studies conducted in rat [39,40] showed that pre-pubertal dictiotene oocytes are less radio-sensitive than are post-pubertal dictiotene oocytes. In the same vein, and according to studies performed by Jacquet’s lab in guinea pig [23,30,79], immature oocyte are less radiation-sensitive than are maturing oocytes, and these are less radiation-sensitivity than are mature oocytes. On the other hand, it has been reported that the chromosomal sensitivity of immature dictiotene oocytes enclosed in primordial follicles is very low in the guinea pig [45].…”

Section: Radiation-induced Genotoxic Effects In Mammalian Female Gmentioning

confidence: 88%

“…, ionizing radiation) refers to the amount (mgr) necessary per weight (kg) to cause death in 50% of the population under study. Early studies used this measure of toxicological effects of ionizing irradiation in mouse [16,58], rat [16,19,20,64], Chinese hamster [33,34,35] and guinea pig [27,28,29,30]. Results have been heterogeneous depending on the species studied and the moment of the irradiation (oocytes and pachynema, diplonema-dictionema or at the moment of birth).…”

Section: Indicators Of Radiation-induced Genotoxic Effectsmentioning

confidence: 99%

“…This includes studies in mouse [16,22], guinea pig [27,28,29,30] and rat [39,40,41]. The results so far are contradictory but the general observed trend is that fertility alterations do not seem to be related to the species irradiated but rather to the irradiation timing.…”

Section: Indicators Of Radiation-induced Genotoxic Effectsmentioning

confidence: 99%

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Radiobiology and Reproduction—What Can We Learn from Mammalian Females?

Ruiz‐Herrera

García

Garcia-Caldés

2012

Genes

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Ionizing radiation damages DNA and induces mutations as well as chromosomal reorganizations. Although radiotherapy increases survival among cancer patients, this treatment does not come without secondary effects, among which the most problematic is gonadal dysfunction, especially in women. Even more, if radio-induced DNA damage occurs in germ cells during spermatogenesis and/or oogenesis, they can produce chromosomal reorganizations associated with meiosis malfunction, abortions, as well as hereditary effects. However, most of our current knowledge of ionizing radiation genotoxic effects is derived from in vitro studies performed in somatic cells and there are only some experimental data that shed light on how germ cells work when affected by DNA alterations produced by ionizing radiation. In addition, these few data are often related to mammalian males, making it difficult to extrapolate the results to females. Here, we review the current knowledge of radiobiology and reproduction, paying attention to mammalian females. In order to do that, we will navigate across the female meiotic/reproductive cycle/life taking into account the radiation-induced genotoxic effects analysis and animal models used, published in recent decades.

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Section: Radiation-induced Genotoxic Effects In Mammalian Female Gmentioning

confidence: 88%

Section: Indicators Of Radiation-induced Genotoxic Effectsmentioning

confidence: 99%

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Radiobiology and Reproduction—What Can We Learn from Mammalian Females?

Ruiz‐Herrera

García

Garcia-Caldés

2012

Genes

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“…Both of these criteria were used to evaluate the effects of drugs on developmental and reproductive function (Jacquet et al, 1997;Adriaens et al, 1999;Wehner et al, 2009). Therefore, our findings could help to clarify mechanisms involved in human embryonic ovarian development and folliculogenesis.…”

Section: Discussionmentioning

confidence: 99%

Cell proliferation and apoptosis in the fetal and neonatal ovary of guinea pigs

et al. 2014

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ABSTRACT. The guinea pig is an excellent animal model for studying reproductive biology of adult humans and most domestic animals. Yet, whether this animal might serve as a good model for embryonic stage investigations and determinations of signals affecting or directing ovary development remains unknown. These questions were addressed by examining morphological evolution and the expression of biomarkers of cell proliferation and apoptosis in the ovaries of fetal and neonatal guinea pigs in the present study. Embryonic and neonatal guinea pigs at 30, 40, 50, 60, and 68 days postcoitum (dpc) and at 1 day postpartum (dpp) were evaluated, and the dynamic changes in follicles between 30 dpc and 1 dpp were observed. Results also showed that a critical period of follicular development in guinea pig embryos occurred at 40 to 50 dpc. Moreover, the proliferating-cell nuclear antigen, a cell proliferation marker, immunohistochemically stained healthy follicles, while caspase-3, an apoptosis marker, was mainly observed in atretic follicles. Together, these results demonstrate that cell proliferation and apoptosis contribute to follicular formation, development, and atresia in fetal and neonatal guinea pig ovaries. Furthermore, this study Cell proliferation and apoptosis in the ovary of guinea pigs confirmed that the guinea pig is also an excellent animal model for studying reproductive biology in human and domestic animal embryos.

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“…The concept of a lethal dose of 50% (LD 50 ) means the dose of a chemical substance or a physical factor which causes death of half of the examined population within a specified time [22]. Initial studies aimed at identification of genotoxic effects induced by IR which used this measure have been conducted on mice [20,51], rats [20,52,53,54], Chinese hamsters [55,56,57] and guinea pigs [58,59]. The results were heterogenous according to the examined species and duration of irradiation.…”

Section: Specificity Of Female Gametogenesis and Studies Of Radiosensmentioning

confidence: 99%

Effect of ionizing radiation on the female reproductive system

Skrzypek¹,

Wdowiak²,

Panasiuk³

et al. 2019

Ann Agric Environ Med.

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Introduction and objective. The tendency towards postponement of maternity implies a greater exposure of female germ cells to damaging environmental effects, including ionizing radiation (IR). Progress in paediatric oncology, based on the use of radiotherapy, also implies the occurrence of gonadal dysfunctions and subsequent female fertility disorders. Therefore, it seems justifiable to systematize the state of knowledge concerning the effect of IR on the female reproductive system. Brief description of the state of knowledge. A considerable part of studies concerning the effect of IR on female germ cells have been conducted on animals. Their extrapolation to humans is hindered because in animal studies high acute exposures are applied, which do not reflect human environmental exposures characterized by chronic low dose exposure. Studies on animals provide a heterogenous image, which hinders the formulation of unequivocal conclusions and indicates that radiosensitivity depends, i.a. on IR dose, stage of development of oocytes, the applied marker of the effects of IR, or on the species. LD50 of human oocytes is estimated to be below 2 Gy. The effect of IR depends, i.a. on the dose fractionation and the age (older women are more radiosensitive). In females, the effective sterilizing dose is: at birth 20.3 Gy, at 10 years 18.4 Gy, at 20 years 16.5 Gy, whereas at 30 years 14.3 Gy, which is associated with the available pool of ovarian follicles. Conclusions. Within the range of low doses received as a result of environmental exposure to IR, there is no evidence for the occurrence of either adverse pregnancy outcomes, nor fertility disorders in females. These effects may be related to the cancer radiotherapy, or exposure to high IR doses during nuclear accidents.

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Cytogenetic effects of X-rays in the guinea pig female germ cells. II. The maturing oocyte

Cited by 12 publications

References 16 publications

Radiobiology and Reproduction—What Can We Learn from Mammalian Females?

Radiobiology and Reproduction—What Can We Learn from Mammalian Females?

Cell proliferation and apoptosis in the fetal and neonatal ovary of guinea pigs

Effect of ionizing radiation on the female reproductive system

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