Cytogenetic monitoring of a group of Italian floriculturists: no evidence of DNA damage related to pesticide exposure

Scarpato, Roberto; Migliore, Lucia; Angotzi, G; Fedi, A.; Miligi, Lucia; Loprieno, N.

doi:10.1016/0165-1218(95)00071-2

Cited by 72 publications

(52 citation statements)

References 44 publications

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“…Assim, aumentos significativos na incidência de aberrações cromossômicas e/ou no intercâmbio de cromátides irmãs, foram constatadas por De Ferrari et al (1991), em floricultores; por Kourakis et al (1992), em trabalhadores em casas de vegetação e por Carbonell et al (1995) e Bréga et al (1998), em trabalhadores de zonas rurais. Em relação aos micronú-cleos, sua freqüência acha-se significativamente aumentada nos floricultores italianos estudados por Bolognesi et al (1993), embora Scarpato et al (1996) relatem achados negativos em estudo semelhante.…”

Section: Discussionunclassified

Instabilidade cromossômica induzida por agroquímicos em trabalhadores rurais na região de Passo Fundo, Rio Grande do Sul, Brasil

Pacheco

Hackel

2002

Cad. Saúde Pública

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Section: Discussionunclassified

Instabilidade cromossômica induzida por agroquímicos em trabalhadores rurais na região de Passo Fundo, Rio Grande do Sul, Brasil

Pacheco

Hackel

2002

Cad. Saúde Pública

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“…Some of them show an increase in genetic damage (Go´mez-Arroyo et al, 2000;Garaj-Vrhovac and Zeljezic, 2002) while others find no differences between these populations and those not exposed to these compounds (Scarpato et al, 1996;Pastor et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Micronucleus analysis in a Portuguese population exposed to pesticides: Preliminary survey

Costa

Silva

Coelho

et al. 2007

International Journal of Hygiene and Environmental Health

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The general population is exposed in their everyday life to different chemicals namely to pesticides. Many of these compounds are capable of inducing mutations in DNA and lead to several diseases including cancer. With this study we intended to evaluate DNA damage inflicted by pesticide exposure in a population occupationally exposed to those chemicals by means of the micronucleus (MN) test. The obtained results showed a significant increase in MN frequency in occupationally exposed individuals (po0.001) compared with the control group. Higher frequencies of MN were associated with a specific workplace (greenhouses) and the lack of protective measures (gloves) during labour activities. These results reinforce that conditions in workplace should be improved to minimize exposure to these chemicals. This study also emphasizes the need to reinforce the good practices campaigns in order to enlighten those who work with pesticides on the potential hazard of occupational exposure and the importance of using protective measures.

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“…The same authors, in another study, detected increased levels of DNA damage using comet assay after 1 day of spraying with mixtures of organophosphates, pyrethroids, and carbamates [Lebailly et al, 1998b]. However, there are studies with negative reports [Scarpato et al, 1996;Lucero et al, 2000;Piperakis et al, 2003] in flower and vegetable cultivators exposed to pesticides. Such negative reports in contrast to ours, could be related with a shorter exposure time, differences in cell processing for the comet assay, and/or better protective measures used by the studied population.…”

Section: Discussionmentioning

confidence: 99%

“…It is estimated that 80% of the total pesticides consumed in Pakistan are used for the protection of cotton crop, from July to October of the growing period though cotton crop accounts for less than 12% of the total cultivated area of the country [Alam, 2006]. Different studies have been conducted in human populations occupationally exposed to pesticides, although the results obtained are conflicting [Scarpato et al, 1996;Venegas et al, 1998;Gómez-Arroyo et al, 2000;Lucero et al, 2000]. One of the possible causes of these divergent data could be the seasonal variations in the levels of pesticide exposure [Carbonell et al, 1995].…”

Section: Introductionmentioning

confidence: 99%

DNA damage in Pakistani agricultural workers exposed to mixture of pesticides

Bhalli

Ali

Asi

et al. 2008

Environ and Mol Mutagen

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A cross-sectional study was designed to determine whether occupational exposure to a complex mixture of pesticides results in a significant increase of DNA damage in farmers chronically exposed to pesticides in open fields. Leukocytes from 47 agriculture workers exposed to pesticides and 50 controls were evaluated with comet assay. Workers recruitment was based on their exposure to pesticides during the spraying season on cotton crop. Serum from these individuals was also analyzed for pesticides presence using high performance liquid chromatography. Statistically significant difference (P < 0.001) in DNA damage of exposed individuals (mean 6 S.D 14.80 6 3.04 lm) was observed when compared with control group (6.54 6 1.73 lm) as studied on the basis of comet tail length. Smokers had significantly higher mean comet tail length than nonsmokers and ex-smokers in both workers (20.26 6 3.53 vs. 14.19 6 4.25, P < 0.001) and controls (7.86 6 1.09 vs. 5.80 6 1.59, P < 0.001), whereas age had a minimal effect on DNA damage (P < 0.05). The length of pesticide exposure is positively associated with DNA damage in exposed individuals (P < 0.001). Our study shows that chronic exposure to pesticides produces DNA damage in pesticide sprayers and suggests that this type of monitoring is recommended in preventive policies for pesticide sprayers. Environ. Mol. Mutagen. 50:37-45, 2009. V V C 2008 Wiley-Liss, Inc.

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Cytogenetic monitoring of a group of Italian floriculturists: no evidence of DNA damage related to pesticide exposure

Cited by 72 publications

References 44 publications

Instabilidade cromossômica induzida por agroquímicos em trabalhadores rurais na região de Passo Fundo, Rio Grande do Sul, Brasil

Instabilidade cromossômica induzida por agroquímicos em trabalhadores rurais na região de Passo Fundo, Rio Grande do Sul, Brasil

Micronucleus analysis in a Portuguese population exposed to pesticides: Preliminary survey

DNA damage in Pakistani agricultural workers exposed to mixture of pesticides

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