Cytogenetic Studies in Unusual Forms of Chronic Myeloid Leukaemia

Absence of the Y Chromosome in Patients with Chronic Granulocytic Leukaemia

“…Several patients [2,5,8,14,20] have survived for over 8 years without transformation to the blast cell phase occurring and have given support to the view that absence of the Y chromosome is associated with a benign course. However, this idea has been chal lenged recently [13] by a report of 2 patients with CGL and absence of the Y chromosome, who had a very short chronic phase of less than 18 months.…”

Preliminary Evidence for the Common Origin of a Lympho-Myeloid Complex in Man

“…In 2 patients with chronic myeloid leukemia, the Philadelphia chromo some was demonstrated in peripheral blood lymphocytes. This finding points to the common origin of lymphocytes and other blood cells in man.It is assumed that, in man, lymphocytes are derived from a different progenitor cell than that from which all the other blood cells arise [11]. The object of the present study was to refute this supposition by examin ing the tissue distribution of the naturally occurring marker for human hemopoietic cells -the Philadelphia (Ph') chromosome -in selected pa tients with chronic myeloid leukemia (CML).…”

Ph1‐Negative Eosinophilic Leukaemia with Trisomy 8 Case Report and Review of Cytogenetic Studies

“…Much has been discussed in the literature whether EL is a variant of chronic granulocytic leukaemia (CGL). In 7 cases a Phlchromosome was found (Kauer & Engle 1964, Elves & Israels 1967, Grunewald et a1 1965, Kiossoglou et a1 1966, Chusid et a1 1975. In the case described by Gruenwald et a1 (1965) the Phl-chromosome was observed in 90 % of the metaphases and at two occasions.…”