Cytogenetic Studies of Normal and Cleft-Palate Epitheliums in Mice

Nasjleti, Carlos E.; Spencer, Herbert H.; Blankenship, John W.; Walden, James M.

doi:10.1177/00220345690480041601

J Dent Res

1969

DOI: 10.1177/00220345690480041601

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Cytogenetic Studies of Normal and Cleft-Palate Epitheliums in Mice

Carlos E. Nasjleti

Herbert H. Spencer

John W. Blankenship

et al.

Abstract: This study investigated teratogenic activity on a cellular level through analysis of the cytogenetic complex in cleft-palate epithelial cells from the progenies of mice treated with cortisone. Analysis showed no detectable aberration from a normal chromosomal complement.

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1974

1984

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Studies on the Relation between Alkylating Agent‐Induced Chromosomal Aberrations and Embryotoxicity in Mice. II. The Potentiation of Teratogenicity and Clastogenicity of Isopropyl Methanesulfonate, N‐Methyl‐N‐Nitrosourea and Dimethyl Sulfate by Caffeine

Nagao

Mizutani

1984

Congenital Anomalies

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The effects of caffeine on embryotoxicity including teratogenicity and clastogenicity of different classes of teratogens were examined in ICR‐mice in order to make clear the relationship between embryotoxicity and induced chromosomal aberrations in embryos. The teratogens used were isopropyl methanesulfonate (IPMS, 100 mg/kg), N‐methyl‐N‐nitrosourea (MNU, 20 mg/kg) and dimethyl sulfate (DMS, 25 mg/kg). In teratological studies, teratogens were given intraperitoneally on day 12 of gestation and caffeine subcutaneously in five divided doses (100 mg/kg for each) at 6 hours intervals during 0–24 hours following the teratogen treatment. In cyto‐genetical studies, teratogens (ip) were administered to ICR‐mice along with caffeine (sc) at a dose of 200 mg/kg on day 12 of gestation. Embryotoxicity was checked on day 18 of gestation, and clastogenicity at 6, 12, 18 and 24 hours following the co‐administration of these drugs. The co‐administration of caffeine and any one of these teratogens induced potentiative response in the formation of gross malformations and particularly in the production of chromosomal aberrations. The data obtained suggest the positive association of teratogenicity with clastogenicity of IPMS, MNU and DMS. Excess cell death due to chromosomal aberrations is highly suggestive as one of the mechanisms of embryotoxicity including teratogenicity of these teratogens.

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Studies on the Relation between Alkylating Agent‐Induced Chromosomal Aberrations and Embryotoxicity in Mice. II. The Potentiation of Teratogenicity and Clastogenicity of Isopropyl Methanesulfonate, N‐Methyl‐N‐Nitrosourea and Dimethyl Sulfate by Caffeine

Nagao

Mizutani

1984

Congenital Anomalies

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Cytogenetic Analysis of Siamese Cats with Cleft Palate

Loevy

1974

J Dent Res

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Cytogenetic Studies of Normal and Cleft-Palate Epitheliums in Mice

Abstract: This study investigated teratogenic activity on a cellular level through analysis of the cytogenetic complex in cleft-palate epithelial cells from the progenies of mice treated with cortisone. Analysis showed no detectable aberration from a normal chromosomal complement.

Cited by 2 publications

References 6 publications

Studies on the Relation between Alkylating Agent‐Induced Chromosomal Aberrations and Embryotoxicity in Mice. II. The Potentiation of Teratogenicity and Clastogenicity of Isopropyl Methanesulfonate, N‐Methyl‐N‐Nitrosourea and Dimethyl Sulfate by Caffeine

Studies on the Relation between Alkylating Agent‐Induced Chromosomal Aberrations and Embryotoxicity in Mice. II. The Potentiation of Teratogenicity and Clastogenicity of Isopropyl Methanesulfonate, N‐Methyl‐N‐Nitrosourea and Dimethyl Sulfate by Caffeine

Cytogenetic Analysis of Siamese Cats with Cleft Palate

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