Cytogenetic Studies of Some Cephalosporines Antibiotics on Mouse Germinal Cells.

Donya, Souria M.

doi:10.1508/cytologia.67.33

Cited by 12 publications

(9 citation statements)

References 20 publications

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“…X-Y univalents were more often separated than autosomal univalents. This phenomenon has also been observed in mice treated with other chemical compounds (Donya 2002, Fahmy et al 2002, 2008.…”

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confidence: 62%

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In vivo Genotoxicity Studies of Cefotaxime

Fahmy¹,

Diab²

2009

cytologia

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Summary Cefotaxime is a semisynthetic broad-spectrum bactericidal antibiotic derived from cephalosporin C. The aim of this work is to evaluate the genotoxic effect induced by intraperitoneal (i.p.) administration of cefotaxime at different doses (260, 520 and 1040 mg/kg b.wt.). The induction of sister chromatid exchanges "SCE's" in mouse bone marrow cells, chromosomal aberrations in mouse primary spermatocytes after repeated treatment (4, 7 and 10 d), and morphological sperm abnormalities were determined. The 3 tested doses of cefotaxime induced significant increase in the frequency of sister chromatid exchanges with dose-dependent relationship. A significant increase in the percentage of structural and numerical chromosomal aberrations in mouse spermatocytes was observed after treatment with the doses 520 and 1040 mg/kg b.wt. Cefotaxime also induced different types of head and tail sperm abnormalities. The results showed that cefotaxime has clastogenic and aneugenic effect.

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confidence: 62%

“…Moreover, Donya (2002) reported that 1st and 2nd generations cephalosporin antibiotics "cefadroxil" and "cefaclor" are potent inducer of chromosomal aberrations in mouse spermatocytes after repeated treatment with the higher therapeutic doses.…”

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confidence: 99%

In vivo Genotoxicity Studies of Cefotaxime

Fahmy¹,

Diab²

2009

cytologia

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“…It should be noticed that X and Y chromosomes were more often separated than autosomes. Numerous mutagens were shown to increase the frequencies of chromosomal univalency in mouse spermatocytes (Allen et al 1986, Hu and Zhu 1990, Donya 2002.…”

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confidence: 99%

Cytogenetic Studies of Berenil in Mice

Donya

2006

CYTOLOGIA

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SummaryThe antitrypanosomal drug Diminazene aceturate (Berenil) was investigated to assess its genotoxic effect through different cytogenetic parameters. Male swiss mice were intraperitoneal (i.p.) injected with therapeutically relevant doses 3.5, 7 and 10.5 mg kg Ϫ1 b.wt. for 1, 3, 5 consecutive days. Berenil increased frequencies of micronucleus in polychromatic erythrocytes especially with high and repeated doses, indicating an aneugenic action. Moreover, marrow toxicity was observed as indicated by significant percentage of chromosome aberrations in bone-marrow cells at all treatment doses. Gaps, fragments and breaks were found to be the most sensitive types of structural aberrations. Polyploidy is a characterized phenomenon of numerical aberrations in treated somatic cells. With respect to germ cells Berenil at the same doses induced high significant percentage of chromosome aberrations (PϽ0.01) in lry spermatocytes after i.p. treatment with 10.5 mg kg Ϫ1 b.wt. for 3 and 5 consecutive days. However, Berenil showed a low influence on sperm abnormalities. Percentage was significant at low level (PϽ0.05) after the treatment with the highest dose. In conclusion, the different cytogenetic parameters indicate its genotoxic effect on the genome of somatic and germ cells especially at multiple doses.

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“…On the contrary, testicular germ cells carrying minor gene mutations are not eliminated but are manifested as morphologically deformed sperm. It is also documented that certain chemicals, including lead acetate, are germ cell mutagens affecting specific gene loci in spermatogonial cells thereby increasing the percentage of sperm abnormality [22][23][24][25] . It is further stated that, sperm cell morphology is genetically controlled by numerous autosomal and sex-linked genes 26) .…”

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confidence: 99%