Lead Acetate Induced Cytotoxicity in Male Germinal Cells of Swiss Mice.

Acharya, Usha; Acharya, S.; Mishra, Monalisa

doi:10.2486/indhealth.41.291

Cited by 68 publications

(48 citation statements)

References 25 publications

(19 reference statements)

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“…"Wadi et al (21) " found that high dose of lead causes increased percentage of abnormal sperm within the epididymis. "Acharya et al (22) " found increased incidence of abnormal sperm population which was in agreement with the present study. "Tohamy et al (23) " found increased percentage (34.31± 1.42) of primary sperm abnormality after high dose of lead treatment than control (15.33± 0.55) which was decreased after giving Vitamin C along with lead (19.35± 0.78) which shows that Vitamin C has ameliorating effect.…”

Section: Discussionsupporting

confidence: 82%

“…We found significant increase in malondialdehyde in group ΙΙ (low dose lead treated) and in group IV (high dose lead treated) as compared to controls. "Shabani and Rabbani (24) ", "Acharya et al (22) ", "Abdel-Wahhab and Aly (25) ", "Abdel-Wahhab et al (26) ", "AbdelWahhab et al (27) ", "Moniem et al (28) ", also reported significant increase in lipid peroxide levels. "Tohamy et al (23) " studied significant increase in malondialdehyde after low and high dose of lead acetate treatment in the semen of male rabbits.…”

Section: Discussionmentioning

confidence: 99%

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Protective Role of Vitamin C on Sperm Morphology and Biochemical Enzymes in Lead Nitrate Treated Albino Rats

Singh¹

2016

jmscr

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Protective Role of Vitamin C on Sperm Morphology and Biochemical Enzymes in Lead Nitrate Treated Albino Rats

Singh¹

2016

jmscr

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“…Reactive oxygen species can originate from endogenous sources such as leukocytes and immature spermatozoa [Aitken and West 1990;Kessopoulou et al 1992;Shekarriz et al 1995], as well as, exogenous sources such as industrial compounds, smoking, and alcohol [Acharya et al 2003;Agarwal and Saleh 2002;Kasahara et al 2002;Koch et al 2004;Kothari et al 2010;Saleh et al 2002b]. In infertile men, the mitochondrion is a major source of endogenous ROS production, which can result in DNA damage and apoptosis in spermatozoa [Barroso et al 2000;Koppers et al 2008].…”

Section: Introductionmentioning

confidence: 99%

Cytosolic and mitochondrial ROS: which one is associated with poor chromatin remodeling?

Kiani-Esfahani¹,

Bahrami²,

Tavalaee³

et al. 2013

Systems Biology in Reproductive Medicine

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The aim of this study was to determine if there are any associations between impaired chromatin packaging and the origin of reactive oxygen species (ROS) production. Cytosolic ROS, mitochondrial ROS, DNA protamination, and apoptosis were evaluated with dichlorofluoresceindiacetate (DCFH-DA), dihydrorhodamine 123 (DHR123), chromomycin A3 (CMA3), and YO-Pro-1 (Y1)/propidium iodide (PI), respectively, by flow cytometry (FCM) in 40 infertile individuals. Percentages DCF+ and R123+ sperm were positively associated with percentage CMA3+ sperm and negatively associated with percentage apoptotic sperm. No correlation was observed between CMA3+ sperm and the percentage of apoptotic sperm. Under protamination of sperm is not associated with the origin of ROS production, but their relationship may suggest an association with general physiological dysfunction of sperm. Furthermore, under protamination does make sperm prone to apoptosis. Rather, it is likely that apoptosis is induced by ROS production. Considering that these conclusions are derived from correlative analyses, additional studies including an interventive approach are required.

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“…Due to the effect of Cd-induced ROS on specific gene loci of germ cell chromosomes, it may dysfunction the maintenance of normal sperm structure. Most of the germ cells have been destroyed in Cd-treated mice due to either membranous or macromolecular damage incurred by formation of ROS leading to declined sperm count and ultimately testicular weight loss (Acharya et al, 2003;Oldereid et al, 1994); as well as the decreased sperm count and alterations in motility have been associated with cigarette smoking (Kulikauskas et al, 1985).…”

Section: Discussionmentioning

confidence: 99%

The protective role of honey against cytotoxicity of cadmium chloride in mice

Shahrour¹,

Zowail²,

Sharafeldin³

2016

Afr. J. Biotechnol.

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The present study aimed to investigate the honey (HY) protective role in opposition to cadmium (Cd) induced chromosomal aberrations of bone marrow and sperm abnormalities. Forty five (45) adult male albino mice were caged into six groups. Mice were injected, i.p, 300 mg HY/kg and/or 0.67 mg CdCl 2 /kg b.w for 96 h, separately and alternated. The alternated trials were continued for consecutive eight days. Results show that mice injected with cadmium had significant increase in the frequency of aberrant chromosomes as fragment, centric fusion, gap, stickiness and aneuploidy and in sperm abnormality. The administration of HY improved the frequency of the chromosomal aberrations and sperm abnormality induced by Cd.

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Lead Acetate Induced Cytotoxicity in Male Germinal Cells of Swiss Mice.

Cited by 68 publications

References 25 publications

Protective Role of Vitamin C on Sperm Morphology and Biochemical Enzymes in Lead Nitrate Treated Albino Rats

Protective Role of Vitamin C on Sperm Morphology and Biochemical Enzymes in Lead Nitrate Treated Albino Rats

Cytosolic and mitochondrial ROS: which one is associated with poor chromatin remodeling?

The protective role of honey against cytotoxicity of cadmium chloride in mice

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