Cytogenetic studies on B‐cell leukemias of akr origin

Abstract

The karyotype of B-cell leukemias of AKR origin was studied by G-banding. In contrast to previous observations indicating trisomy of chromosome 15 in spontaneous and chemically-induced B-cell leukemias, 11 out of 15 tumors analyzed had normal diploid karyotypes. Four tumors with the modal number 39-41 had different chromosome markers specific for each tumor. The possible correlation between non-random chromosomal changes and the target cell involved in the initial transformation in AKR leukemogenesis is discussed.

Distinct chromosomal abnormalities in murine leukemia virus‐induced T‐ and B‐cell lymphomas

“…It is interesting to compare our findings in MuLV-induced B-cell lymphomas with those of a cytogenetic study (Trakhtenbrot et al, 1987) of B-cell lymphomas arising in thymectomized AKR mice. Strikingly, those AKR B-cell tumors which had multiple cytogenetic abnormalities in that study were the ones which had a relatively long latency.…”

“…Various other numerical aberrations have also been documented (Dofuku et al, 1975;Chang et al, 1977;Wiener et al, 1978aWiener et al, ,b, 1981Carbonell et a!., 1982Carbonell et a!., , 1987McMorrow et al, 1988). The few B-cell lymphomas studied thus far were hyperdiploid, comprising various types of monosomies, trisomies (predominantly trisomy 15) and marker chromosomes, but normal karyotypes have also been observed (Fialkow et al, 1980;Wiener et af., 1981;Trakhtenbrot et al, 1987).…”