Cytogenetic study of workers exposed to methyl-parathion

Biomonitoring with the comet assay of Greek greenhouse workers exposed to pesticides

“…A clastogenic effect in human somatic cells has also been observed [Kourakis et al, 1992[Kourakis et al, , 1996. However, some of these positive findings have not been substantiated by other investigators [Rabello et al, 1975;Hogstedt et al, 1980;De Cassia et al, 1982]. Variations in the degree of exposure or the use of different pesticides and assays may explain the differences between studies [Scarpato et al, 1996].…”

Frequency of sister chromatid exchange and hematological effects in pesticide-exposed greenhouse sprayers

“…In previous epidemiologic investigations significant increases in chromosome damage have been observed in cultured lymphocytes from pesticide-exposed workers (6)(7)(8)(9)(10). Other studies have failed to detect cytogenetic damage (11)(12)(13)(14). This contradiction is probably the result of variation in pesticide exposure because of differences in the crops, work habits, and pesticides used among the agricultural workers studied.…”

Sperm aneuploidy among Chinese pesticide factory workers: Scoring by the FISH method

“…Evidence of clastogenicity and mutagenicity of methyl and ethyl parathion have been reported in some studies and includes sister chromatid exchange in cell lines [Chen et al, 1981] and human chromosome aberrations [Kiraly et al, 1979;Van Bao et al, 1974;Vijayaraghavan and Nagarajan, 1994]. However, other studies have found no such effects in mice [Degraeve and Moutschen, 1984] or in humans [De Cassia Stocco et al, 1982].…”