Cytogenic analysis of lymphocytes from fiberglass-reinforced plastics workers occupationally exposed to styrene

Hummelen, Paul Van; Severi, Mario; Pauwels, W; Roosels, D; Veulemans, Hendrik; Kirsch‐Volders, Micheline

doi:10.1016/0027-5107(94)90020-5

Cited by 24 publications

(9 citation statements)

References 28 publications

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“…MNCB was indeed the only genotoxicity parameter consistently influenced by smoking habits (Tables V and VI). In the literature, the effects of smoking on the outcome of comet [Andreoli et al, 1997;Lebailly et al, 1998] and micronucleus assays [Tomanin et al, 1991;Van Hummelen et al, 1993;Van Hummelen et al, 1994] are, however, controversial.…”

Section: Discussionmentioning

confidence: 99%

Absence of significant genotoxicity in lymphocytes and urine from workers exposed to moderate levels of cobalt-containing dust: A cross-sectional study

Boeck

Lardau

Buchet

et al. 2000

Environ. Mol. Mutagen.

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Section: Discussionmentioning

confidence: 99%

Absence of significant genotoxicity in lymphocytes and urine from workers exposed to moderate levels of cobalt-containing dust: A cross-sectional study

Boeck

Lardau

Buchet

et al. 2000

Environ. Mol. Mutagen.

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“…Other studies of micronuclei in humans have also found older age to be associated [Yager, 1990b;Migliore et al, 1991], offering some validation of our data. Some studies have found female gender [Catalan et al, 1995;Fenech, 1993], smoking and alcohol consumption [da Cruz et al, 1994;Van Hummelen et al, 1994] to be positively associated with micronuclei level as well. In our data there was an indication of higher micronuclei levels among persons with a history of cancer, so they were excluded from the pooled analysis (n ϭ 3), as was one person on thyroid medication with a very high micronuclei level.…”

Section: Discussionmentioning

confidence: 99%

“…Micronuclei counts have been found elevated with exposure to toluene [Nise et al, 1991], antineoplastic, or cytotoxic drugs [Machado-Santelli et al, 1994;Anwar et al, 1994], and industrial painting [DiGiorgio et al, 1994], but not to 1,3-butadiene [Sorsa et al, 1994] or chloralkali [Hansteen et al, 1993]. Several studies found conflicting results for occupational exposure to styrene [Anwar and Shamy, 1995;Van Hummelen et al, 1994;Tates et al, 1994] and to PAHs in soot [Holmen, 1994;Carstensen et al, 1993;Van Hummelen et al, 1993]. Inconsistencies in results may be attributable to different assay methods, exposure levels, choice of comparison group and control of confounders.…”

Section: Other Studies Of Genotoxicitymentioning

confidence: 99%

Genetic monitoring of malathion-exposed agricultural workers

et al. 1998

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The aerial application of malathion over large urban populations in Southern California during the early 1990s raised concerns about adverse health effects, including the potential to cause genetic damage. Workers in the Mediterranean fruit fly eradication program, which involved application of malathion as ground treatment, were studied to examine micronucleus formation and mutation frequencies assessed by the glycophorin A (GPA) assay. In the 1992 pilot project the mean micronuclei level appeared higher in lymphocytes of exposed workers (n = 13) compared to controls (n = 4) (20.1 ± 7.1 vs 14.3 ± 7.2 respectively, P = 0.09). During the 1993 season, neither of the cohorts examined showed a higher level of micronuclei in workers exposed to malathion compared to unexposed, nor did the pooled total (n = 53; means = 17.8 ± 7.2 vs 18.5 ± 6.3, respectively), even after adjustment by multiple regression. The GPA variant frequency was not associated with malathion exposure in any of the cohorts. These results suggest that any potential risk of genotoxic damage from exposure to malathion is relatively low, but other assays may be more sensitive, and the sample size was small. Am. J. Ind. Med. 33:164‐174, 1998. © 1998 Wiley‐Liss, Inc.

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“…A total of 53 publications were retrieved and screened; 37 were not relevant to our analysis and were discarded, as described in the flow chart. Sixteen full-text articles were assessed for eligibility and five of them were excluded because of insufficient data reporting [21,22], lack of a control group [23] or due to concurrent exposure to other known genotoxic compounds [24,25]. As a consequence eleven articles [26][27][28][29][30][31][32][33][34][35][36] were left for the inclusion in the review.…”

Section: Results Of the Literature Searchmentioning

confidence: 99%

The cytokinesis-block micronucleus (CBMN) assay in human populations exposed to styrene: A systematic review and meta-analysis

Costa

Ceppi

Costa

et al. 2016

Mutation Research/Reviews in Mutation Research

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Styrene is a building-block of several compounds used in a wide array of materials and products. The most important human exposure to this substance occurs in industrial settings, especially among reinforced-plastics industry workers. The effect of occupational exposure to styrene on cytogenetics biomarkers has been previously reviewed with positive association observed for chromosomal aberrations, and inconclusive data for the micronucleus assay. Some limitations were noted in those studies, including inadequate exposure assessment and poor epidemiological design. Furthermore, in earlier studies micronuclei frequency was measured with protocols not as reliable as cytokinesis-block micronucleus (CBMN) assay. Aim of the present systematic review and meta-analysis is to investigate genomic instability and DNA damage as measured by the CBMN assay in lymphocytes of subjects exposed to styrene. A total of 11 studies published between 2004 and 2012 were included in the meta-analysis encompassing 479 styrene-exposed workers and 510 controls. The quality of each study was estimated by a quality scoring system which ranked studies according to the consideration of major confounders, exposure characterization, and technical parameters. An overall increase of micronuclei frequencies was found in styrene-exposure workers when compared to referents (meta-MR 1.34; 95% CI 1.18-1.52), with significant increases achieved in six individual studies. The consistency of results in individual studies, the independence of this result from major confounding factors and from the quality of the study strengthens the reliability of risk estimates and supports the use of the CBMN assay in monitoring genetic risk in styrene workers.

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Cytogenic analysis of lymphocytes from fiberglass-reinforced plastics workers occupationally exposed to styrene

Cited by 24 publications

References 28 publications

Absence of significant genotoxicity in lymphocytes and urine from workers exposed to moderate levels of cobalt-containing dust: A cross-sectional study

Absence of significant genotoxicity in lymphocytes and urine from workers exposed to moderate levels of cobalt-containing dust: A cross-sectional study

Genetic monitoring of malathion-exposed agricultural workers

The cytokinesis-block micronucleus (CBMN) assay in human populations exposed to styrene: A systematic review and meta-analysis

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