Cytokine and Cancer Biomarkers Detection: The Dawn of Electrochemical Paper-Based Biosensor

Loo, Song Wei; Pui, Tze Sian

doi:10.3390/s20071854

Cited by 43 publications

(32 citation statements)

References 90 publications

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“…Some review articles have been reported focusing on immunosensing [ 2 ] or label-free bioanalysis [ 1 ] using both optical and electrochemical detection. In addition, one paper reporting the use of electrochemical paper-based biosensors [ 18 ] for the determination of cytokines has been recently published. However, to our knowledge, there is not a comprehensive review on electrochemical biosensing strategies for the determination of cytokines involved in the inflammatory processes, underlying the diseases that threaten our society, including emerging infectious diseases such as the current global COVID-19 pandemic [ 19 ].…”

Section: Conventional Methods For the Determination Of Cytokinesmentioning

confidence: 99%

Revisiting Electrochemical Biosensing in the 21st Century Society for Inflammatory Cytokines Involved in Autoimmune, Neurodegenerative, Cardiac, Viral and Cancer Diseases

Campuzano

Yáñez‐Sedeño

Pingarrón

2020

Sensors

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The multifaceted key roles of cytokines in immunity and inflammatory processes have led to a high clinical interest for the determination of these biomolecules to be used as a tool in the diagnosis, prognosis, monitoring and treatment of several diseases of great current relevance (autoimmune, neurodegenerative, cardiac, viral and cancer diseases, hypercholesterolemia and diabetes). Therefore, the rapid and accurate determination of cytokine biomarkers in body fluids, cells and tissues has attracted considerable attention. However, many currently available techniques used for this purpose, although sensitive and selective, require expensive equipment and advanced human skills and do not meet the demands of today’s clinic in terms of test time, simplicity and point-of-care applicability. In the course of ongoing pursuit of new analytical methodologies, electrochemical biosensing is steadily gaining ground as a strategy suitable to develop simple, low-cost methods, with the ability for multiplexed and multiomics determinations in a short time and requiring a small amount of sample. This review article puts forward electrochemical biosensing methods reported in the last five years for the determination of cytokines, summarizes recent developments and trends through a comprehensive discussion of selected strategies, and highlights the challenges to solve in this field. Considering the key role demonstrated in the last years by different materials (with nano or micrometric size and with or without magnetic properties), in the design of analytical performance-enhanced electrochemical biosensing strategies, special attention is paid to the methods exploiting these approaches.

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Section: Conventional Methods For the Determination Of Cytokinesmentioning

confidence: 99%

Revisiting Electrochemical Biosensing in the 21st Century Society for Inflammatory Cytokines Involved in Autoimmune, Neurodegenerative, Cardiac, Viral and Cancer Diseases

Campuzano

Yáñez‐Sedeño

Pingarrón

2020

Sensors

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“…As a versatile detection tool, paper-based biosensors have been widely used in medical diagnostics for home/POC testing and laboratory uses. Recent studies have exploited this assay format for detecting infections [ 102 , 103 ], cancer biomarkers [ 104 ], and other diseases [ 105 , 106 ] based on antigens or antibodies, which can potentially be used for COVID-19. For instance, Brangel et al [ 102 ] introduced a paper-based serology test for POC detection of ebola virus infections (Fig.…”

Section: Recent Advances In Poc Technologies For Covid-19mentioning

confidence: 99%

Emerging point-of-care biosensors for rapid diagnosis of COVID-19: current progress, challenges, and future prospects

Rasmi

Khan

et al. 2021

Anal Bioanal Chem

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Coronavirus disease 2019 (COVID-19) pandemic is currently a serious global health threat. While conventional laboratory tests such as quantitative real-time polymerase chain reaction (qPCR), serology tests, and chest computerized tomography (CT) scan allow diagnosis of COVID-19, these tests are time-consuming and laborious, and are limited in resource-limited settings or developing countries. Point-of-care (POC) biosensors such as chip-based and paper-based biosensors are typically rapid, portable, cost-effective, and user-friendly, which can be used for COVID-19 in remote settings. The escalating demand for rapid diagnosis of COVID-19 presents a strong need for a timely and comprehensive review on the POC biosensors for COVID-19 that meet ASSURED criteria: Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free, and Deliverable to end users. In the present review, we discuss the importance of rapid and early diagnosis of COVID-19 and pathogenesis of COVID-19 along with the key diagnostic biomarkers. We critically review the most recent advances in POC biosensors which show great promise for the detection of COVID-19 based on three main categories: chip-based biosensors, paper-based biosensors, and other biosensors. We subsequently discuss the key benefits of these biosensors and their use for the detection of antigen, antibody, and viral nucleic acids. The commercial POC biosensors for COVID-19 are critically compared. Finally, we discuss the key challenges and future perspectives of developing emerging POC biosensors for COVID-19. This review would be very useful for guiding strategies for developing and commercializing rapid POC tests to manage the spread of infections.

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“…Considering the demand on hospitals during the COVID19 pandemic, developing such sensors for personal use would help identify patients in need of further medical attention. In addition, electrochemical sensors are typically more portable, and faster than many LBTs (immunoassays, mass spectrometry) [ 24 ]. However, confounding variables when using electrochemical sensors, such as pH, can alter the performance of the sensor and must be considered when such an electrochemical sensor is produced [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical sensing: A prognostic tool in the fight against COVID-19

Kotru

Klimuntowski

Ridha

et al. 2021

TrAC Trends in Analytical Chemistry

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Cytokine and Cancer Biomarkers Detection: The Dawn of Electrochemical Paper-Based Biosensor

Cited by 43 publications

References 90 publications

Revisiting Electrochemical Biosensing in the 21st Century Society for Inflammatory Cytokines Involved in Autoimmune, Neurodegenerative, Cardiac, Viral and Cancer Diseases

Revisiting Electrochemical Biosensing in the 21st Century Society for Inflammatory Cytokines Involved in Autoimmune, Neurodegenerative, Cardiac, Viral and Cancer Diseases

Emerging point-of-care biosensors for rapid diagnosis of COVID-19: current progress, challenges, and future prospects

Electrochemical sensing: A prognostic tool in the fight against COVID-19

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