Cytokine concentration in stored canine erythrocyte concentrates

Corsi, Raffaella; McMichael, Maureen; Smith, Stephanie A.; O'Brien, Mauria; Herring, Jennifer; Ngwenyama, Thandeka R.; Galligan, Alyssa; Beloshapka, Alison N.; Deng, Ping; Swanson, Kelly S.

doi:10.1111/vec.12160

Cited by 37 publications

(73 citation statements)

References 31 publications

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“…) and dogs (Corsi et al . ). This proinflammatory cytokine might be a contributing factor for systemic inflammation and for transfusion‐associated complications.…”

Section: Discussionmentioning

confidence: 97%

Exploration of risk factors for non‐survival and for transfusion‐associated complications in cats receiving red cell transfusions: 450 cases (2009 to 2017)

Martínez‐Sogues

Blois

Manzanilla

et al. 2020

J of Small Animal Practice

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Objectives To describe red blood cell transfusion practices and short‐term outcomes in anaemic cats. To determine clinical variables associated with non‐survival and transfusion‐related complications. Material and Methods In this retrospective study, blood bank records from the Ontario Veterinary College Health Science Centre (OVC‐HSC) were reviewed to identify cats that received packed red blood cells or whole blood from 2009 to 2017. We extracted cause of anaemia, history of previous transfusion, pre‐ and post‐transfusion packed cell volume, pre‐transfusion compatibility testing, volume and dose of blood product, age of red blood cell unit, transfusion‐associated complications and patient survival. Results A total of 450 transfusion events were recorded in 267 cats. Blood loss was the most common indication for blood transfusion (44.9%), followed by ineffective erythropoiesis (37.5%) and red blood cell destruction (22.5%). Transfusion‐associated complications occurred in 10.2% events and there was a 20.2% mortality after transfusion. Mean increase in packed cell volume 24‐hours after transfusion was greater in cats undergoing major cross‐match testing before transfusion (7.2%) versus those that did not (4.0%). Non‐survival was associated with higher packed cell volume before transfusion, low patient body temperature before transfusion, anaemia due to blood loss and number of transfusions administered. Older age of transfused blood units was associated with non‐survival and transfusion‐related complications. Clinical Importance This study was observational and so our analyses were exploratory, but suggest that major cross‐match before transfusion tended to have greater transfusion efficacy and transfusion of older blood products might have detrimental effects on survival.

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“…) and dogs (Corsi et al . ). This proinflammatory cytokine might be a contributing factor for systemic inflammation and for transfusion‐associated complications.…”

Section: Discussionmentioning

confidence: 97%

Exploration of risk factors for non‐survival and for transfusion‐associated complications in cats receiving red cell transfusions: 450 cases (2009 to 2017)

Martínez‐Sogues

Blois

Manzanilla

et al. 2020

J of Small Animal Practice

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“…As storage time increases in non‐leucoreduced blood, certain inflammatory mediators, such as interleukin‐8, also accumulate in the supernatant (Corsi et al . ). Interleukin‐8 is a potent chemoattractant for white blood cells.…”

Section: Introductionmentioning

confidence: 97%

“…, Corsi et al . ). The purpose of this study was to describe the changes in select biochemical components of the storage lesion in commercially available feline packed red blood cells.…”

Section: Introductionmentioning

confidence: 97%

Biochemical evaluation of the effects of storage on feline erythrocytes

Heinz

Pashmakova

Wilson

et al. 2016

J of Small Animal Practice

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“…[1][2][3][4][5] Interleukin (IL)-1β, IL-8 and tumour necrosis factor-α (TNF-α) are the cytokines that increase in human whole blood and packed red blood cells (PRBCs) during storage. 6 A study in anaesthetised Greyhounds 7 used as terminal blood donors showed significant changes in blood pressure, cardiac index and oxygen extraction ratio, consistent with haemorrhagic shock. 6 A study in anaesthetised Greyhounds 7 used as terminal blood donors showed significant changes in blood pressure, cardiac index and oxygen extraction ratio, consistent with haemorrhagic shock.…”

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confidence: 99%

“…1,[3][4][5][6] Both human and canine recipients of nonleucoreduced (NLR) PRBCs have evidence of enhanced inflammation compared with those that receive leucoreduced (LR) PRBCs. 1,[3][4][5][6] Both human and canine recipients of nonleucoreduced (NLR) PRBCs have evidence of enhanced inflammation compared with those that receive leucoreduced (LR) PRBCs.…”

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confidence: 99%

Interleukin‐8, interleukin‐1β and tumour necrosis factor‐α in sequential units of packed red blood cells collected from retired racing Greyhounds

et al. 2017

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Background We hypothesised that concentrations of interleukin-8 (IL-8), interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) would increase during storage in the third sequential unit (U3) of canine packed red blood cells (PRBC) collected from terminal donors in haemorrhagic shock. We further hypothesised that leucoreduction would prevent cytokine accumulation in U3 and that cytokine concentrations in U3 would be higher than in the first units (U1) collected from the same dogs.Methods U1 and U3 were each collected from 12 anaesthetised healthy Greyhounds. Removal of leucocytes from half of each PRBC unit produced one leucoreduced (LR) and one nonleucoreduced (NLR) unit. Canine IL-8, IL-1β and TNF-α concentrations were measured in samples collected from the units during storage on days 0, 10, 20, 30 and 37. ResultsThe IL-8 concentration in U3 NLR units was significantly higher on days 10, 20, 30 and 37 than on day 0 and was significantly higher than in the LR units at all time points. The IL-1β concentration in U3 did not change over time, or between LR and NLR units. TNF-α was not detected in any unit. There were no significant differences in IL-8 or IL-1β concentrations between U3 and U1 at any time point; however, some NLR U3 units had markedly elevated IL-8 concentrations at day 37 (2060-20,682 pg/mL) compared with NLR U1 units (3369-5280 pg/mL).Conclusion NLR U3 units collected from dogs in haemorrhagic shock showed a significant increase in IL-8 concentrations during storage. Leucoreduction was effective at preventing the accumulation of IL-8. There was no difference detected between U3 and U1.

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Cytokine concentration in stored canine erythrocyte concentrates

Abstract: This study demonstrated a marked, storage time-dependent accumulation of IL-8 in canine erythrocyte concentrates. Prestorage LR attenuated the accumulation of IL-8. This chemokine may contribute to the proinflammatory effects of transfusion of stored erythrocyte concentrates.

Cited by 37 publications

References 31 publications

Exploration of risk factors for non‐survival and for transfusion‐associated complications in cats receiving red cell transfusions: 450 cases (2009 to 2017)

Exploration of risk factors for non‐survival and for transfusion‐associated complications in cats receiving red cell transfusions: 450 cases (2009 to 2017)

Biochemical evaluation of the effects of storage on feline erythrocytes

Interleukin‐8, interleukin‐1β and tumour necrosis factor‐α in sequential units of packed red blood cells collected from retired racing Greyhounds

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