Cytokine Concentrations in Aqueous Humor of Eyes With Circumscribed Choroidal Hemangioma

Liu, Kailin; Guo, Lili; Cheng, Yong; Liang, Jianhong

doi:10.3389/fendo.2022.916789

Cited by 3 publications

(1 citation statement)

References 23 publications

(25 reference statements)

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“…It has the advantages of high throughput, high sensitivity, small sample size, and low cost. Luminex multiplex microsphere arrays are now being used to measure multiple aqueous humor factors simultaneously 21,22 .…”

Section: Introductionmentioning

confidence: 99%

Changes of aqueous humor cytokine profiles of patients with high intraocular pressure after PPV for retinal detachment

Zhu,

Cheng,

Tang

et al. 2023

Preprint

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High ocular pressure is one of the early complications after pars plana vitrectomy (PPV), which may cause glaucoma and poor visual prognosis secondary to surgery. It’s essential for the basic mechanism to analyze the relative humor cytokine profiles and clinical factors with intraocular pressure (IOP) after PPV for retinal detachment (RD). In this study, we have collected the aqueous humor of 16 patients with high IOP after PPV and 16 patients with normal IOP after PPV. We qualified 27 cytokines using Luminex multiplex cytokines analysis and compared biomarkers with high IOP group and normal group. In a result, the concentration of VEGF, IL-6, FGF2, and G-CSF upregulated significantly (P < 0.05), while VEGFR2 downregulated significantly (P < 0.05) in high IOP group. IL-6 was positively correlated with high IOP (r = 0.561, P = 0.041). Meanwhile, the concentration of IL-6 (r = 0.543, P = 0.03), IL-5 (r = 0.576, P = 0.019), IL-15 (r = 0.614, P = 0.011), IL-4 (r = 0.517, P = 0.04), ICAM-1 (r = 0.611, P = 0.012) and G-CSF (r = 0.636, P = 0.008) were significantly associated with preoperative PVR classification, and the aqueous humor levels of IL-4 (r = 0.567, P = 0.022), HGF (r = 0.701, P = 0.005), and MCP-1 (r = 0.565, P = 0.035) are significant relative to laser points. Hence, cytokines might potentially be the therapeutic target of high IOP after PPV.

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Section: Introductionmentioning

confidence: 99%

Changes of aqueous humor cytokine profiles of patients with high intraocular pressure after PPV for retinal detachment

Zhu,

Cheng,

Tang

et al. 2023

Preprint

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New insights on circumscribed choroidal hemangioma: “bench to bedside”

Lupidi

Centini

Castellucci

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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Circumscribed choroidal hemangioma is a rare vascular hamartoma of the choroid, presenting as a red–orange mass at the posterior pole on fundoscopic examination. Despite its benign origin, associated complications such as subretinal fluid, serous retinal detachment, retinoschisis and neovascular glaucoma may lead to serious visual impairment in more than half patients. Because of its similarity to amelanotic choroidal melanoma and choroidal metastasis, differential diagnosis is still challenging for specialists. Multimodal imaging such as ultrasonography, fluorescein angiography, indocyanine green angiography, optical coherence tomography, and optical coherence tomography angiography guides the clinician to the correct diagnosis and the proper follow-up. Treatment is indicated in symptomatic cases in order to resolve exudation and improve visual acuity. Treatment options include photocoagulation, transpupillary thermotherapy, radiation therapy, photodynamic therapy and anti-vascular endothelial growth factor therapy. Currently, photodynamic therapy is the treatment of choice due to its effectiveness and safety. The purpose of this review is to describe the latest knowledge in the etiopathogenesis of the circumscribed choroidal hemangioma, the most recent multimodal imaging findings, and the available treatment options.

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Changes of aqueous humor cytokine profiles of patients with high intraocular pressure after PPV for retinal detachment

Zhu,

Cheng,

Tang

et al. 2024

Sci Rep

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High intraocular pressure (IOP) is one of the early complications after pars plana vitrectomy (PPV), which may cause glaucoma and poor visual prognosis secondary to surgery. Proliferative vitreoretinopathy (PVR) is one of the complications of retinal detachment (RD) and is the main reason for the poor prognosis, which is related to different kinds of cytokines. It’s essential for the basic mechanism to analyze the relative aqueous humor cytokine profiles with IOP after PPV for RD. In this study, we have collected the aqueous humor of 16 patients and qualified 27 cytokines using Luminex and compared biomarkers with the high IOP group and the normal group. As a result, the concentrations of VEGF, IL-6, FGF2, and G-CSF upregulated significantly (P < 0.05), while VEGFR2 downregulated significantly (P < 0.05) in the high IOP group. IL-6 was positively correlated with high IOP (r = 0.561, P = 0.041). Meanwhile, the concentrations of IL-6 (r = 0.543, P = 0.03), IL-5 (r = 0.576, P = 0.019), IL-15 (r = 0.614, P = 0.011), IL-4 (r = 0.517, P = 0.04), ICAM-1 (r = 0.611, P = 0.012), and G-CSF (r = 0.636, P = 0.008) were significantly associated with preoperative PVR classification, and the aqueous humor levels of IL-4 (r = 0.567, P = 0.022), HGF (r = 0.701, P = 0.005), and MCP-1 (r = 0.565, P = 0.035) are significant relative to laser points. Hence, cytokines might potentially be the therapeutic target of high IOP after PPV.

show abstract

Cytokine Concentrations in Aqueous Humor of Eyes With Circumscribed Choroidal Hemangioma

Cited by 3 publications

References 23 publications

Changes of aqueous humor cytokine profiles of patients with high intraocular pressure after PPV for retinal detachment

Changes of aqueous humor cytokine profiles of patients with high intraocular pressure after PPV for retinal detachment

New insights on circumscribed choroidal hemangioma: “bench to bedside”

Changes of aqueous humor cytokine profiles of patients with high intraocular pressure after PPV for retinal detachment

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