Cytokine dysbalance in type 2 diabetes mellitus patients with prior myocardial infarction

Abstract

he article presents the results of the study of C-reactive protein, interleukin-6, tumor necrosis factor-α and interleukin-10 levels in postmyocardial infarction patients with type 2 diabetes mellitus. It was identified significantly higher concentrations of C-reactive protein, proinflammatory interleukin-6 and tumor necrosis factor-α and anti-inflammatory interleukin-10 in comparison with the control group. The study found that the combination of postinfarction cardiosclerosis and type 2 diabetes mellitus shows higher degree of activity of markers of systemic inflammation than in isolated course of disease, when identical anti-inflammatory protection. The data shows that the blood glucose levels directly affect the concentration of C-reactive protein and interleukin-10, whereas insulin resistance directly depends on the activity of inflammation markers.