Cytokine Expression in Patients with Bladder Pain Syndrome/Interstitial Cystitis ESSIC Type 3C

Logadóttir, Ýr; Delbro, Dick; Fall, Magnus; Gjertsson, Inger; Jirholt, Pernilla; Lindholm, Catharina; Peeker, Ralph

doi:10.1016/j.juro.2014.04.099

Cited by 54 publications

(57 citation statements)

References 25 publications

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“…IC patients have high urinary concentrations of immunoglobulin and inflammatory markers, or high serum levels of C‐reactive protein, NGF and pro‐inflammatory cytokines . Bladders with Hunner type IC show diffuse and intense inflammation and overexpression of pro‐inflammatory genes .…”

Section: Pathophysiologymentioning

confidence: 99%

Clinical guidelines for interstitial cystitis and hypersensitive bladder updated in 2015

Ueda²,

et al. 2016

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Clinical guidelines for interstitial cystitis and hypersensitive bladder have been updated as of 2015. The guidelines define interstitial cystitis by the presence of hypersensitive bladder symptoms (discomfort, pressure or pain in the bladder usually associated with urinary frequency and nocturia) and bladder pathology, after excluding other diseases explaining symptoms. Interstitial cystitis is further classified by bladder pathology; either Hunner type interstitial cystitis with Hunner lesions or non-Hunner type interstitial cystitis with mucosal bleeding after distension in the absence of Hunner lesions. Hypersensitive bladder refers to a condition, where hypersensitive bladder symptoms are present, but bladder pathology or other explainable diseases are unproven. Interstitial cystitis and hypersensitive bladder severely affect patients' quality of life as a result of disabling symptoms and/or comorbidities. Reported prevalence suggestive of these disorders varies greatly from 0.01% to >6%. Pathophysiology would be an interaction of multiple factors including urothelial dysfunction, inflammation, neural hyperactivity, exogenous substances and extrabladder disorders. Definite diagnosis of interstitial cystitis and hypersensitive bladder requires cystoscopy with or without hydrodistension. Most of the therapeutic options lack a high level of evidence, leaving a few as recommended therapeutic options.

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Section: Pathophysiologymentioning

confidence: 99%

Clinical guidelines for interstitial cystitis and hypersensitive bladder updated in 2015

Ueda²,

et al. 2016

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“…138 Transcript levels of proinflammatory cytokines are also increased in IC/PBS bladder. 139 A heightened inflammatory response can be related to bladder urothelial dysfunction as many components of urine metabolites, such as potassium, which is highly concentrated in urine, are toxic to underlying tissue. As described above, stress has a profound effect on visceral sensitivity, but its impact on urothelium specifically remains to be elucidated.…”

Section: Interstitial Cystitis/painful Bladder Syndromementioning

confidence: 99%

Stress and Chronic Pelvic Pain

Pierce¹,

Christianson²

2015

Progress in Molecular Biology and Translational Science

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“…In contrast, studies investigating serum biomarkers in cats with acute or chronic FIC have not been performed to date. Because FIC may be associated with factors that can induce systemic immune activation and pro‐inflammatory cytokine release (eg, bladder inflammation, comorbid nonurinary inflammatory conditions, and activation of sympathetic nervous system), characterization of serum cytokine and chemokine responses could offer additional insight into the pathogenesis of FIC and identify potential noninvasive biomarkers for diagnosis, prognosis, and prediction of therapeutic responses. In 1 study of 22 nonobstructed cats with chronic FIC, serum concentrations of tryptophan and its metabolite kynurenine were higher in FIC cats compared to healthy controls, but differences did not reach statistical significance …”

mentioning

confidence: 99%

Serum Cytokine Profiling in Cats with Acute Idiopathic Cystitis

Parys

Yuzbasiyan‐Gurkan

Kruger

2018

Veterinary Internal Medicne

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BackgroundFeline idiopathic cystitis (FIC) is a common lower urinary tract disorder of domestic cats that resembles interstitial cystitis/painful bladder syndrome (IC/PBS) in humans. Diagnosis of FIC is based on clinical signs and exclusion of other disorders because of a lack of specific pathologic findings or other objective biomarkers. Cytokines are potential noninvasive biomarkers to define the presence, severity, and progression of disease, and response to treatment.ObjectivesThe objective of this pilot study was to determine concentrations of selected cytokines in serum from healthy cats and cats with acute FIC.AnimalsSerum samples from 13 healthy cats and from 12 cats with nonobstructive acute FIC were utilized.MethodsMultiplex analysis of 19 cytokines (CCL2, CCL5, CXCL1, CXCL12, CXCL8, Flt3L, GM‐CSF, IFN‐γ, IL‐12 (p40), IL‐13, IL‐18, IL‐1β, IL‐2, IL‐4, IL‐6, PDGF‐BB, SCF, sFas, and TNF‐α) was performed with a commercially available feline‐specific multiplex bead‐based assay.ResultsMean serum concentrations of IL‐12 (p40; P < 0.0001), CXCL12 (P = 0.002), IL‐18 (P = 0.032), and Flt3L (P = 0.0024) were significantly increased in FIC cats compared to healthy cats. GM‐CSF, IL‐1b, IL‐2, and PDGF‐BB were undetectable or detected in an insufficient number of cats to allow meaningful comparisons.Conclusions and Clinical ImportanceWe have identified increased serum concentrations of pro‐inflammatory cytokines and chemokines CXCL12, IL‐12, IL‐18, and Flt3L in FIC‐affected cats. These findings suggest potential candidates for noninvasive biomarkers for diagnosis, staging, and therapeutic outcome monitoring of affected cats and provide additional insight into the etiopathogenesis of FIC.

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Cytokine Expression in Patients with Bladder Pain Syndrome/Interstitial Cystitis ESSIC Type 3C

Abstract: Patients with bladder pain syndrome/interstitial cystitis had increased mRNA levels of IL-17A, 10 and 6, and iNOS. IL-17A might be important in the inflammatory process. To our knowledge the increase in IL-17A is a novel finding that may have new treatment implications.

Cited by 54 publications

References 25 publications

Clinical guidelines for interstitial cystitis and hypersensitive bladder updated in 2015

Clinical guidelines for interstitial cystitis and hypersensitive bladder updated in 2015

Stress and Chronic Pelvic Pain

Serum Cytokine Profiling in Cats with Acute Idiopathic Cystitis

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